JP7326157B2 - Hbvワクチン - Google Patents

Hbvワクチン Download PDF

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JP7326157B2
JP7326157B2 JP2019555196A JP2019555196A JP7326157B2 JP 7326157 B2 JP7326157 B2 JP 7326157B2 JP 2019555196 A JP2019555196 A JP 2019555196A JP 2019555196 A JP2019555196 A JP 2019555196A JP 7326157 B2 JP7326157 B2 JP 7326157B2
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hbv
seq
viral vector
sequence
sii
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JP2020516264A5 (enExample
JP2020516264A (ja
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バーンズ,エリノア
チンナカンナン,センディル
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Oxford University Innovation Ltd
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    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/10Transferases (2.)
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    • C12N9/1241Nucleotidyltransferases (2.7.7)
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    • C12N9/14Hydrolases (3)
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    • C12N9/22Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N2710/24111Orthopoxvirus, e.g. vaccinia virus, variola
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JP2019555196A 2017-04-10 2018-04-10 Hbvワクチン Active JP7326157B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1705765.4 2017-04-10
GBGB1705765.4A GB201705765D0 (en) 2017-04-10 2017-04-10 HBV vaccine
PCT/GB2018/050948 WO2018189522A1 (en) 2017-04-10 2018-04-10 Hbv vaccine

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Publication Number Publication Date
JP2020516264A JP2020516264A (ja) 2020-06-11
JP2020516264A5 JP2020516264A5 (enExample) 2021-05-20
JP7326157B2 true JP7326157B2 (ja) 2023-08-15

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JP2019555196A Active JP7326157B2 (ja) 2017-04-10 2018-04-10 Hbvワクチン

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US (2) US20200113998A1 (enExample)
EP (1) EP3609535B1 (enExample)
JP (1) JP7326157B2 (enExample)
KR (1) KR102700586B1 (enExample)
CN (2) CN110913899B (enExample)
AU (1) AU2018251241B2 (enExample)
CA (1) CA3059290A1 (enExample)
DK (1) DK3609535T3 (enExample)
ES (1) ES3036962T3 (enExample)
GB (1) GB201705765D0 (enExample)
MX (1) MX2019012101A (enExample)
MY (1) MY202396A (enExample)
PH (1) PH12019502310A1 (enExample)
SG (1) SG11201909353VA (enExample)
WO (1) WO2018189522A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11020476B2 (en) 2017-12-19 2021-06-01 Janssen Sciences Ireland Unlimited Company Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV)
EA202091513A1 (ru) 2017-12-19 2020-09-09 Янссен Сайенсиз Айрлэнд Анлимитед Компани Вакцины против вируса гепатита b (hbv) и их применение
EA202091517A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и устройство для доставки вакцин против вируса гепатита b (hbv)
US20220339281A1 (en) * 2019-03-05 2022-10-27 GalxoSmithKline Biologicals SA Hepatitis b immunisation regimen and compositions
US20220305107A1 (en) * 2019-06-18 2022-09-29 Janssen Sciences Ireland Unlimited Company COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND HBV-TARGETING RNAi
WO2020255055A1 (en) * 2019-06-20 2020-12-24 Janssen Sciences Ireland Unlimited Company Self-replicating rna molecules for hepatitis b virus (hbv) vaccines and uses thereof
CA3149415A1 (en) 2019-08-29 2021-03-11 Eric Bruening Hepatitis b virus vaccines
EP4458975A3 (en) * 2019-09-30 2025-02-12 Gilead Sciences, Inc. Hbv vaccines and methods treating hbv
WO2021243149A2 (en) * 2020-05-28 2021-12-02 President And Fellows Of Harvard College Protein covariance networks reveal interactions important to the emergence of sars coronaviruses as human pathogens
PH12023550030A1 (en) * 2020-07-08 2024-03-11 Janssen Sciences Ireland Unlimited Co Rna replicon vaccines against hbv
JPWO2022071513A1 (enExample) 2020-10-02 2022-04-07
TW202245809A (zh) * 2020-12-18 2022-12-01 美商詹森藥物公司 用於治療b型肝炎病毒感染之組合療法
CN115595312A (zh) * 2021-06-28 2023-01-13 中国农业大学(Cn) 一种重组腺病毒及其应用
US20250000968A1 (en) * 2021-11-12 2025-01-02 The United States of America, as represented by the Secretary,Department of Health and Human Service Sars-cov-2 spike fused to a hepatitis b surface antigen
US20230310591A1 (en) 2021-12-07 2023-10-05 Vaccitech (Uk) Limited Vaccine Boost Methods and Compositions
WO2024193905A1 (en) * 2023-03-17 2024-09-26 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Hbv antigen formulation for treating hepatitis b
GB202317925D0 (en) 2023-11-23 2024-01-10 Spybiotech Ltd Vaccines
CN118593695B (zh) * 2024-08-07 2024-10-22 山东兴瑞生物科技有限公司 一种用于治疗HBV感染的siRNA和mRNA联合疫苗

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006526409A (ja) 2003-06-03 2006-11-24 セル ジェネシス インコーポレイテッド ペプチド開裂部位を用いた単一ベクターからの組換えポリペプチドの高められた発現のための構成と方法
JP2013501038A (ja) 2009-08-07 2013-01-10 トランジェーヌ、ソシエテ、アノニム Hbv感染を治療するための組成物
JP2014527404A (ja) 2011-07-12 2014-10-16 トランジェーヌ、ソシエテ、アノニムTransgene S.A. Hbvポリメラーゼ変異体
WO2015082922A1 (en) 2013-12-04 2015-06-11 Isis Innovation Limited Molecular adjuvant

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101573449B (zh) * 2006-08-14 2013-09-18 浦项工大产学协力团 用于治疗慢性乙型肝炎的dna疫苗及其制备方法
AP2013007110A0 (en) * 2011-02-12 2013-09-30 Globeimmune Inc Yeast-based therapeutic for chronic hepatitis B infection
CN103173492B (zh) * 2013-03-12 2014-08-13 中国人民解放军白求恩国际和平医院 携带外源基因的复制型hbv载体、其转染后产生的重组hbv,和相应的制备方法与应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006526409A (ja) 2003-06-03 2006-11-24 セル ジェネシス インコーポレイテッド ペプチド開裂部位を用いた単一ベクターからの組換えポリペプチドの高められた発現のための構成と方法
JP2013501038A (ja) 2009-08-07 2013-01-10 トランジェーヌ、ソシエテ、アノニム Hbv感染を治療するための組成物
JP2014527404A (ja) 2011-07-12 2014-10-16 トランジェーヌ、ソシエテ、アノニムTransgene S.A. Hbvポリメラーゼ変異体
WO2015082922A1 (en) 2013-12-04 2015-06-11 Isis Innovation Limited Molecular adjuvant

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal of Hepatology, 2018.4, Vol.68, pp.S789-S790, #SAT-407
Vaccines, 2020, Vol.8, #184, <doi:10.3390/vaccines8020184>

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US20240115694A1 (en) 2024-04-11
SG11201909353VA (en) 2019-11-28
KR20200024130A (ko) 2020-03-06
MY202396A (en) 2024-04-25
GB201705765D0 (en) 2017-05-24
KR102700586B1 (ko) 2024-08-30
JP2020516264A (ja) 2020-06-11
AU2018251241B2 (en) 2025-04-17
EP3609535A1 (en) 2020-02-19
CN118576699A (zh) 2024-09-03
DK3609535T3 (da) 2025-08-18
US20200113998A1 (en) 2020-04-16
ES3036962T3 (en) 2025-09-25
CN110913899B (zh) 2024-04-19
WO2018189522A1 (en) 2018-10-18
MX2019012101A (es) 2019-12-11
AU2018251241A1 (en) 2019-10-31
EP3609535B1 (en) 2025-06-25
CA3059290A1 (en) 2018-10-18
PH12019502310A1 (en) 2020-09-21
CN110913899A (zh) 2020-03-24

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