JP7320666B2 - Skin topical compositions with enhanced anti-inflammatory efficacy - Google Patents

Description

The present invention is a topical skin composition with enhanced anti-inflammatory efficacy wherein (A) about 1.05-8 fold, preferably about 1.1-4 fold, more preferably about 1.2 concentrated birch sap with ~2-fold enrichment and (B) one selected from the group consisting of oat (Avena sativa) grain extract, panthenol, allantoin, bisabolol and dipotassium glycyrrhizinate, or It relates to topical skin compositions comprising multiple active agents.

As the socio-economic level changes, the types and ingredients of cosmetics become more complex, the potential for sensitive skin becomes more and more irritated, and people's awareness of skin health and aesthetic standards increases. Along with the improvement in skin sensitivity, attention to sensitive skin has gradually increased. The cosmetics industry has placed increasing emphasis on products for sensitive skin and has developed active anti-allergic ingredients for various reasons and reactions of sensitive skin. According to existing market research, almost all cosmetic brands, with the exception of some, have released a certain number and different types of products for sensitive skin. Foreign brands such as Avene, Shiseido and other well-known brands offer a wide range of products. Herborist, a domestic brand, has a differentiated brand image of “nourishing the skin with herbal medicine”, coupled with the emergence of new cosmetic brands in recent years, such as pure plant functional cosmetics such as Yuze and Winona. But it's unique. In these "soothing" cosmetics, several plant extracts with anti-allergic and anti-irritant effects are added in varying degrees, such as purslane, chamomile, tea polyphenols and siberian purslane oil. These ingredients have anti-allergic and anti-irritant properties, relieve skin allergies, provide a natural protective barrier for the skin, effectively repair damaged skin, promote biochemical synthesis of cellular proteins and cell regeneration. , can rebuild the skin immune system.

Birch is a deciduous tree belonging to the Betulaceae family, and currently there are about 100 species in the world, mainly distributed in the north temperate zone and cool temperate zone. Of these, about 29 species exist in China, mainly distributed in the northeast, northwest and southwest. It plays an important role in preventing soil erosion, improving the environment and controlling wind and sand. Birch trees grow primarily in remote mountainous areas with little human intervention and no industrial pollution. Birch sap (also known as birch sap) is the fresh sap from the cut birch bark or from the drilled trunk. Birch sap is colorless or pale yellow, has no sediment or impurities, and has a slight birch aroma. Birch sap contains a large number of compounds such as sugars, amino acids, vitamins, biotin, cytokinins, trace mineral elements, aromatic oils, betulins and saponins, and has good moisturizing, anti-inflammatory, anti-wrinkle, whitening and other skin care benefits. have sex.

In one aspect, the present invention provides (A) concentrated birch sap and (B) oat grain extract, panthenol, allantoin, bisabolol and glycyrrhizin in topical skin compositions having enhanced anti-inflammatory efficacy. The use of a combination with one or more active agents selected from the group consisting of dipotassium acid, about 1.05 to 8 times concentrated birch sap, preferably about 1.1 to 4 times, more preferably has an enrichment of about 1.2-2 fold, for use.

In another aspect, the present invention is a topical skin composition having enhanced anti-inflammatory efficacy wherein (A) about 1.05-8 fold, preferably about 1.1-4 fold, more preferably and (B) one selected from the group consisting of oat (oat) grain extract, panthenol, allantoin, bisabolol and dipotassium glycyrrhizinate. or to topical skin compositions comprising multiple active agents.

The birch sap involved in the present invention is of the genus Birch, including the four varieties Betala alba, Betula pubescens, Betula Pendula and Betula platyphylla. from the family (Betula Betulaceae). Birch sap is a clear, colorless nutrient with no precipitants or impurities, obtained by artificial drilling and collection from the base of birch tree trunks from the time the snow begins to melt until the time the tree leaves. It is a sap rich in Birch sap is commercially available and used as is (in which case it is referred to as the original fluid), for example from Daxinganling Chaoyue Wild Berry Development Co., Ltd. , Ltd. can be purchased from

The concentrated birch sap according to the present invention is obtained by concentrating the above mentioned commercial birch sap concentrate product. Concentration methods are known in the art, such as thermal concentration, cold and vacuum concentration, and membrane concentration. In the present invention, concentration is preferably carried out by cryogenic freeze concentration or membrane concentration methods. For example, a commercially available birch sap stock solution is introduced into a low temperature drying device, cooled to about -40 to -70°C, and cooled to about 0°C for low temperature and vacuum concentration methods to obtain concentrated birch sap with different degrees of concentration. .1-30 Pa is evacuated.

Furthermore, the inventors have also discovered that the anti-inflammatory efficacy of concentrated birch sap does not have a simple linear relationship with its concentration, increasing initially and then decreasing with increasing concentration. Therefore, it is important to adjust the concentration of birch sap. In the present invention, the concentration of birch sap is adjusted to about 1.05-8 times, preferably about 1.1-4 times, more preferably about 1.2-2 times.

Surprisingly, we found that the use of concentrated birch sap and oat (oat) grain extract, panthenol, allantoin, bisabolol or dipotassium glycyrrhizinate alone compared ) The combination of grain extract, panthenol, allantoin, bisabolol and/or dipotassium glycyrrhizinate has significantly better anti-inflammatory efficacy, much higher than these additive effects, and a synergistic effect between them I found that it shows that there is

The content of the concentrated birch sap of component (A) is about 18-98%, preferably about 20-95%, more preferably about 22-90%, most preferably about 20-95%, based on the total weight of the topical skin composition. Preferably it is about 30-90%.

Component (B) oat (oat) kernel extract, panthenol, allantoin, bisabolol or dipotassium glycyrrhizinate are all known in the art and commercially available.

The content of component (B) is about 0.01-10%, preferably 0.1-6%, more preferably 0.5-5%, based on the total weight of the topical skin composition. .

Skin topical compositions include pharmaceutical compositions or cosmetic compositions.
A topical skin composition does not include any added water, but does not exclude water inherently contained in each of its components.

In one preferred embodiment, the topical skin composition is free of chelating agents such as EDTA salts, sodium phosphate, sodium metaphosphate and gluconic acid.

In addition to components (A) and (B), the topical skin composition optionally includes (C) a topical skin composition including, but not limited to, vehicles, active ingredients and excipients. It may contain ingredients commonly used in products. Component (C) is known in the art. Those skilled in the art can select the type and amount as necessary. For example, the total content of component (C) is usually about 2-80% based on the total weight of the topical skin composition.

Vehicles include, for example, diluents, dispersants or carriers. Examples include, but are not limited to, ethanol, dipropylene glycol, butanediol, and the like. The content of vehicle in topical skin compositions is known in the art, eg it is typically about 0.5-20% of the total weight of component (C).

Active ingredients include emollients, moisturizers, anti-inflammatory active ingredients, and the like.
Examples of emollients include, but are not limited to, olive oil, macadamia nut oil, sweet almond oil, grape seed oil, avocado oil, corn oil, sesame oil, soybean oil, peanut oil, meadowfoam seed oil, safflower seed. oil, rosa canina fruit oil, argania spinosa kernel oil, simmondsia chinensis seed oil, sunflower seed oil, mauritia flexuosa fruit oil, squalane, ethylhexyl palmitate, isopropyl myristate, hydrogenated poly isobutylene, isocetane, isododecane, diethylhexyl carbonate, dioctyl carbonate, isopropyl lauroyl sarcosinate, isononyl isononanoate, hydrogenated polydecene, triethylhexanoin, cetyl ethylhexanoate, bis-diethoxydiglycol cyclohexane 1,4-dicarboxylate, One or more of caprylic/capric triglyceride, oleyl erucate, octyldodecanol myristate, octyldodecanol, polydimethylsiloxane, octylpolymethylsiloxane, cetyldimethicone, cyclopentadimethylsiloxane, and the like. Examples of solid emollients include, but are not limited to, cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, squalyl alcohol, lauric acid, myristic acid, palmitic acid, stearic acid, beeswax, candelilla Wax, carnauba wax, lanolin, ozokerite, jojoba seed wax, paraffin wax, microcrystalline wax, hardened rice bran wax, hardened cocoglycerides, glyceryl behenate/eicosadioate, myristyl myristate, bis-diglyceryl polyacyl adipate 2, one or more of butyrospermum parkii (shea butter) and Astropotassium murumuru seed butter. The content of emollients in topical skin compositions is known in the art, eg it is typically 1-50% based on the total weight of component (C).

Examples of water retention agents include, but are not limited to, glycerin, diglycerin, butylene glycol, propylene glycol, 1,3-propanediol, dipropylene glycol, 1,2-pentanediol, polyethylene glycol-8, polyethylene Glycol-32, Methylgluceth-10, Methylgluceth-20, PEG/PPG-17/6 Copolymer, Glycereth-7, Glycereth-26, Glycerylglucoside, PPG-10 Methylglucose Ether, PPG-20 Methylglucose Ether, PEG/PPG/ polybutylene glycol-8/5/3 glycerol, sucrose, trehalose, rhamnose, mannose, raffinose, betaine, erythritol, xylitol, urea, glycereth-5 lactate, sodium hyaluronate, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate, one or more of sodium polyglutamate, hydrolyzed sclerotium gum, pullulan, tremellam and tamarind seed polysaccharides, 1,2-hexanediol, natural moisturizers, ceramide 2, ceramide 3, cholesterol, phospholipids, etc. There are several. The content of moisturizing agents in topical skin compositions is known in the art, eg it is typically about 1-30% of the total weight of component (C).

Examples of anti-inflammatory active ingredients include, but are not limited to, PORTULACA OLERACEA extract, biological sugar gum-1, β-glucans, fructans, Scutellaria BAICALENSIS ) Root Extract, Horse Chestnut (AESCULUS HIPPOCASTANUM) Extract, 4-Tert-Butyl Cyclohexanol, Hydrogenated Lecithin, Licorice Glycyrrhiza (GLYCYRRHIZA GLABRA) Extract, Hydrolyzed Royal Jelly Protein, Oryzanol, Phytosphingosine, Quercetin, Ginger Root Extract , rosemary leaf extract, and the like. The content of anti-inflammatory active ingredients in topical skin compositions is known in the art, eg it is usually about 0.01-10% of the total weight of component (C).

Excipients include, for example, emulsifiers, thickeners, preservatives, flavoring agents, and the like.
Examples of emulsifiers include, but are not limited to, cetearyl oleate, sorbitan oleate, polysorbate-60, polysorbate-80, methylglucose sesquistearate, PEG-20 methylglucose sesquistearate, PEG-40 Hydrogenated Castor Oil, PPG-26-Buteth-26, PEG-4 Polyglyceryl-2 Stearate, PEG-60 Hydrogenated Castor Oil, Steareth-2, Steareth-21, PPG-13-decyltetradeceth-24, Cetearyl Glucoside , PEG-100 stearate, glyceryl stearate, glyceryl stearate SE, cocoglucoside, ceteareth-25, PEG-40 stearate, polyglyceryl-3-methylglucose distearate, glyceryl stearate citrate, polyglyceryl-10 stearate, myristin Polyglyceryl-10 acid, Polyglyceryl-10 dioleate, Polyglyceryl-10 laurate, Polyglyceryl-10 isostearate, Polyglyceryl-10 oleate, Polyglyceryl-10 diisostearate, Polyglyceryl-6 laurate, Polyglyceryl-6 myristate, Sucrose stearate and one or more of sucrose polystearate. The content of emulsifiers in topical skin compositions is known in the art, eg it is typically 0.5-10% of the total weight of component (C).

Examples of thickening agents include, but are not limited to, macromolecular polymers such as carbomer, acrylates and derivatives thereof, xanthan gum, gum arabic, polyethylene glycol-14M, polyethylene glycol-90M, succinyl polysaccharides, hydroxyethylcellulose, hydroxy One or more of propylcellulose and hydroxypropylmethylcellulose are included. The content of thickeners in topical skin compositions is known in the art, eg it is typically 0.1-10% of the total weight of component (C).

Examples of preservatives include, but are not limited to, methyl hydroxybenzoate, propyl hydroxybenzoate, phenoxyethanol, benzyl alcohol, phenyl ethanol, bis(hydroxymethyl)imidazolidinyl urea, potassium sorbate, sodium benzoate, chloro Chlorophenesin, sodium dehydroacetate, caprylhydroxamic acid, 1,2-hexanediol, 1,2-pentanediol, p-hydroxyacetophenone, caprylyl glycol, glyceryl caprylate, glyceryl undecylenate, sorbitan caprylate, ethylhexyl One or more of glycerol, peony root extract, and the like. The content of preservatives in topical skin compositions is known in the art, eg it is typically 0.01-2% of the total weight of component (C).

A topical skin composition with enhanced anti-inflammatory efficacy according to the present invention can be prepared by any suitable method known in the art. For example, it can be prepared using devices commonly used in the cosmetic field, such as dissolving tanks, emulsifying pots, dispersers, transfer pumps, and the like. During preparation, the water-soluble material is charged into the water-phase dissolution kettle, the oil-soluble material is charged into the oil-phase dissolution kettle, and the two kettles are each heated to about 80°C, and for ingredients that easily agglomerate, disperse. It can be pre-dispersed using a machine. Once dissolution is complete, the oil and water phases are transferred to an emulsifying pot and homogenized and emulsified for about 5-15 minutes. Once emulsification is complete, the bulk is cooled to room temperature and optionally fragrances, preservatives, etc. are added and the pH of the product is adjusted as required.

The above preparation method can be changed or adjusted according to the requirements of the dosage form. The topical composition for skin of the present invention can be prepared into various dosage forms such as ointments, creams, emulsions, lotions, essences, sprays and gels, as required.

The invention is explained in more detail below with reference to examples. It is to be understood, however, that these examples and comparative examples are used only to illustrate the invention and are not intended to be used in any way as defined in the appended claims of this invention. It should not be understood as limiting the scope.
Example 1 Effect of Different Substance Systems on Irritant Contact Dermatitis In this example, based on a mouse model of irritant contact dermatitis, birch sap stock solution, birch sap concentrate, oat (oat) grain extract and/or The anti-inflammatory efficacy of panthenol was evaluated.

1. Experimental animal: ICR mouse, male2. Experimental materials: 10% sodium dodecyl sulfate solution (SDS), depilatory cream, birch sap, oat (oat) grain extract, panthenol3. Experimental method: ICR mice were randomly grouped according to their weight, with 12 mice in each group, and divided into normal group, model group and formula group. One day before modeling, mice in each group were treated with depilatory cream to remove hair on an area of approximately 2 x 2 cm on the abdomen of the mice. For model group and formulation group: On the day of modeling, 50 μL of 10% sodium lauryl sulfate solution was aspirated using a pipette and evenly applied to the exposed skin of mouse abdomen for 5 consecutive days. Each formulation group solution was nebulized using the same aerosol bottle, and each mouse was evenly nebulized twice each time, three times a day for two consecutive days. In the normal group, the mice were dehaired from the abdomen by the same method and fed for 7 days to serve as control. On the 7th day of the experiment, the skin conditions of the experimental mice in each group were observed, and the serum of the mice was collected to determine the content of the inflammatory factor IL-1α.

The prescription was as follows:

1.2-fold, 4-fold and 9-fold concentrated birch sap were obtained by concentrating the birch sap stock solution. The concentration method was as follows: Daxinganling Chaoyue Wild Berry Development Co.; , Ltd. A fresh birch (Betula alba) sap stock solution purchased from Co., Inc. was supplied to a cryogenic drying device, cooled to −65° C., evacuated to 0.1 Pa, and concentrated 1.2, 4 and 9 times, respectively. .

4. The inflammatory factor IL-α content of mouse sera after treatment with different formulations is shown in the table below:

The results in the table above demonstrate that the combination of oat (oat) kernel extract or panthenol with birch sap significantly inhibits the expression of IL-α in the serum of mice with irritant contact dermatitis. Indicated. Furthermore, the combination with 1.2-fold concentrated birch sap showed better efficacy.
Example 2: Effect of different cosmetic composition systems on allergic contact dermatitis1. Experimental animal: ICR mouse, male2. Experimental materials: 1% DNFB acetone olive oil solution (4:1), depilatory cream, birch sap, allantoin, bisabolol3. Experimental method: ICR mice were randomly grouped according to their body weight, with 12 mice in each group, and divided into normal group, model group and formula group. One day before modeling, mice in each group were treated with depilatory cream to remove hair on an area of approximately 2 x 2 cm on the abdomen of the mice. For the model group and the prescription group: On the day of modeling, 100 μL of acetone olive oil solution containing 1% DNFB was aspirated and evenly applied to the exposed skin of the abdomen of mice to sensitize them and to treat allergic contact dermatitis in mice. urged the establishment of the model. It was applied for 2 consecutive days, and on the 5th day, 20 μL of 1% DNFB acetone olive oil solution was evenly applied to the inner and outer ear of the mice for stimulation. Acetone and olive oil solution (4:1) was evenly applied to the abdomen and ears of normal group mice for control.

Dosing began 12 hours after stimulation, and the same aerosol bottle was used for each formulation group to apply the same aerosol bottle to the inner and outer ear of the experimental mice, once to the inner and outer ear of each ear, three times a day, for two consecutive days. was sprayed on. The model group was sprayed with distilled water three times a day for two consecutive days, and the inner and outer ears were repeatedly rubbed with a cotton swab for about 5 seconds.

The prescription was as follows:

4. Evaluation indicators:
Ear Thickness Index: Mouse ear thickness was measured 12 hours and 48 hours after stimulation and the mean value for the ears was taken.

Ear Weight Index: Two days after dosing, the left ear disc of each experimental mouse was removed using a punch and weighed.

Determination of inflammation index: 2 days after administration, mouse serum was collected, and the inflammatory factors IFN-γ, IL-4 and tryptase content in mouse ear tissue were detected using ELISA kit, and IFN-γ/IL-4 was calculated.

5. Experimental result

The above results showed that the combination of birch sap and allantoin or bisabolol significantly inhibited inflammation and balanced the ratio of IFN-γ/IL-4 in serum. Furthermore, the combination with 1.2-fold concentrated birch sap showed better efficacy.
Example 3 Effect of Birch Sap on Mast Cell Degranulation In this example, birch sap and glycyrrhizic acid were used on mast cell degranulation to demonstrate the anti-inflammatory efficacy of birch sap and dipotassium glycyrrhizinate. The effect of combination with dipotassium was tested and compared by using the zebrafish juvenile allergy model.

The experimental method was as follows.
1. Experimental animal: zebrafish.

2. The experimental steps were as follows: AB wild-type zebrafish embryos were collected and cultured in an incubator at 28.5° C. with E3 buffer up to 5 dpf (days post fertilization), changing the buffer daily, Zebrafish at 5 dpf were randomly transferred to 48-well cell culture plates in groups of 10 fish per well, 4 replicate wells per group, grouped as follows:
Model group: RO water + 15 μg/ml SP
Positive group: ketotifen + 15 μg/ml SP
Group of samples tested:

Corresponding to the above degranulation groups with SP, a negative control group without SP was established with 4 replicate wells per group, with a degranulation group introduced with SP and a negative control group without SP. Correspondingly, a background control group (no zebrafish larvae) was established with two replicate wells per group. The E3 buffer remaining in the wells of each group was absorbed, 250 μl of the corresponding solution was added to each group, and reacted for 60 minutes in an incubator at 28.5° C. in the dark. After 60 minutes, 200 μl of supernatant of each group was placed in a 96-well cell culture plate and the enzymatic reaction substrate BAPNA was added respectively to achieve a concentration of 400 μg/ml. The 96-well plate was covered in the dark, placed in an incubator at 28.5°C, and allowed to react for 2 hours. All plates are measured for light absorbance values at 405 nm after 2 hours, values reflecting tryptase release in zebrafish mast cells.

Experimental results for the zebrafish juvenile mast cell protection model are recorded in the table below.

The results in the table above showed that the combination of birch sap and dipotassium glycyrrhizinate significantly inhibited mast cell degranulation. Furthermore, the combination with 1.2-fold concentrated birch sap showed better efficacy.
Example 4: Anti-Inflammatory Facial Cream Composition The formulation of the anti-inflammatory facial cream composition was shown as follows:

An anti-inflammatory facial cream composition was prepared as follows:
1. Raw material 4 was uniformly dispersed with raw material 11;
2. Raw material 7 was heated and dissolved by raw material 10;
3. The raw materials 1 and 25 are charged into the water phase pot and dispersed while being stirred together with the raw material 12. After the raw material 12 has completely dissolved, and 25 were added and heated up to 80°C;
4. Feedstocks 13, 14, 15, 16, 17, 18, 19, 20, 21, 22 were charged into the oil phase pot and heated to 80°C;
5. The ingredients in the water phase pot were pumped into the emulsification pot and homogenized at high speed for 5 minutes;
6. The ingredients in the oil phase pot were pumped into the emulsification pot, homogenized at high speed for 5 minutes and held for 10 minutes;
7. Cooled to 50° C. with stirring, charged raw materials 23 and 24 and slowly homogenized for 3 minutes;
8. Cooled to 40° C. with stirring;
9. The product was tested before being discharged.

Thirty-nine subjects with sensitive skin and facial irritation were selected and divided into three groups: Group 1 was treated sequentially with the facial cream composition; Group 2 was a control without birch sap. A third group was treated with product A (formulation was exactly as described in the table above, but all birch sap was replaced with water); treated with allantoin, panthenol and oat kernel extract replaced with water).

Results after 4 weeks showed that the facial cream composition significantly improved the patient's facial inflammatory response and enhanced skin stability compared to the two control products.
Example 5: Anti-inflammatory extract composition The formulation of the anti-inflammatory extract composition was as follows:

An anti-inflammatory extract composition was prepared as follows:
1. Raw material 3 was uniformly dispersed with raw material 11;
2. Ingredient 1 is charged into an emulsifying pot, ingredients 14 and 15 are dispersed while stirring, and ingredients 2, 3, 4, 5, 6, 7, 8, 9, 10, 2, 3, 4, 5, 6, 7, 8, 9, 10, Add 11, 12 and 13, heat up to 80° C. with stirring, homogenize at high speed for 5 minutes, hold for 10 minutes;
3. Cool to 50° C. with stirring, add ingredients 16, 17 and 18 and homogenize at high speed for 5 minutes;
4. Cool to 50° C. with stirring and add ingredients 19 and 20;
5. Cooled to 40° C. with stirring;
6. The product was tested before being discharged.

In this example, 39 subjects with sensitive skin and facial irritation were selected and divided into 3 groups: Group 1 was treated sequentially with an extract composition; Group 2 was treated with birch sap. Group 3 was treated with control product B (formulation was as described above); treated with exactly the same as described in the table, but with all bisabolol and oat kernel extract replaced with water);
Results after 4 weeks showed that the extract composition significantly improved the patient's facial inflammatory response and enhanced skin stability compared to the two control products.
Example 6: Anti-Inflammatory Lotion Composition The formulation of the anti-inflammatory lotion composition was as follows:

An anti-inflammatory lotion composition was prepared as follows:
1. Ingredient 4 was uniformly dispersed with ingredient 9;
2. Raw material 1 was charged into an emulsifying pot, raw material 11 was dispersed while stirring, and raw materials 2, 3, 4, 5, 6, 7, 8, 9, 10, and 17 were added after raw material 11 was completely expanded. .

3. Heat to 80° C. with stirring, homogenize at high speed for 5 minutes, hold for 10 minutes.
4. Ingredient 12 was added and homogenized at high speed for 5 minutes and held for 10 minutes.

5. After cooling to 60° C. with stirring, ingredient 13 was added.
6. Cooled to 50° C., added ingredients 14 and 15, and slowly homogenized for 3 minutes.

7. Cooled to 40° C. with stirring;
8. The product was tested before being discharged.

In this example, 39 subjects with sensitive skin and facial irritation were selected and divided into 3 groups: Group 1 was treated sequentially with a lotion composition; Group 2 was treated with birch sap. Group 3 was treated with control product B (formulation was as described above); just as described in the table, but all dipotassium glycyrrhizinate and allantoin were replaced with water);
Results after 4 weeks showed that the lotion composition significantly improved the patient's facial inflammatory response and enhanced skin stability compared to the two control products.

The technical solutions in the above examples were the preferred embodiments of the present invention. Several improvements and changes can be made without departing from the principle of the present invention, and these improvements and changes should also be considered to fall within the protection scope of the present invention.

Claims (6)

A skin topical composition having anti-inflammatory efficacy, comprising: (A )1 . concentrated birch sap having a 2- to 8 -fold concentration and (B) one or more activities selected from the group consisting of oat (oat) grain extract, panthenol, allantoin, bisabolol and dipotassium glycyrrhizinate. containing substances,
A topical skin composition that does not contain any water to which said topical skin composition is further added . A skin topical composition according to claim 1, wherein said concentrated birch sap has a concentration of 1.2 to 4 times. A skin topical composition according to claim 2, wherein said concentrated birch sap has a concentration of 1.2-2 fold. The topical composition for skin according to any one of claims 1 to 3, wherein the content of said component (A) concentrated birch sap is 18-98% relative to the total weight of said composition for topical skin. Composition. The topical composition for skin according to any one of claims 1 to 3, wherein the content of said component (B) is 0.01 to 10% relative to the total weight of said topical composition for skin. thing. 4. The topical skin composition according to any one of claims 1 to 3 , wherein said topical skin composition is a pharmaceutical composition or a cosmetic composition.