JP7315466B2 - 生体試料中において改善した性能を有する、ｔｉｍｐ２に関するアッセイ - Google Patents

生体試料中において改善した性能を有する、ｔｉｍｐ２に関するアッセイ Download PDF

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JP7315466B2
JP7315466B2 JP2019554789A JP2019554789A JP7315466B2 JP 7315466 B2 JP7315466 B2 JP 7315466B2 JP 2019554789 A JP2019554789 A JP 2019554789A JP 2019554789 A JP2019554789 A JP 2019554789A JP 7315466 B2 JP7315466 B2 JP 7315466B2
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antibody
amino acid
acid sequence
seq
antibodies
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JP2020516603A (ja
JP2020516603A5 (https=
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ラヴィ エー． ヴィジャイェンドラン，
スリヴァタサ ヴェンカタスッバラオ，
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アスチュート メディカル，インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2019554789A 2017-04-05 2018-04-04 生体試料中において改善した性能を有する、ｔｉｍｐ２に関するアッセイ Active JP7315466B2 (ja)

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JP2023115029A JP2023145528A (ja) 2017-04-05 2023-07-13 生体試料中において改善した性能を有する、ｔｉｍｐ２に関するアッセイ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762482089P 2017-04-05 2017-04-05
US62/482,089 2017-04-05
PCT/US2018/026058 WO2018187453A1 (en) 2017-04-05 2018-04-04 Assays for timp2 having improved performance in biological samples

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JP2023115029A Division JP2023145528A (ja) 2017-04-05 2023-07-13 生体試料中において改善した性能を有する、ｔｉｍｐ２に関するアッセイ

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JP2020516603A JP2020516603A (ja) 2020-06-11
JP2020516603A5 JP2020516603A5 (https=) 2021-05-13
JP7315466B2 true JP7315466B2 (ja) 2023-07-26

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JP2023115029A Pending JP2023145528A (ja) 2017-04-05 2023-07-13 生体試料中において改善した性能を有する、ｔｉｍｐ２に関するアッセイ

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Country Link
US (2) US11718682B2 (https=)
EP (1) EP3606554A4 (https=)
JP (2) JP7315466B2 (https=)
CN (1) CN110709103B (https=)
WO (1) WO2018187453A1 (https=)

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NZ605698A (en) 2010-06-23 2015-03-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
ES2734494T3 (es) 2011-12-08 2019-12-10 Astute Medical Inc Métodos y usos para el diagnóstico de una lesión renal y de una insuficiencia renal
TR201807542T4 (tr) 2013-01-17 2018-06-21 Astute Medical Inc Böbrek hasarı ve böbrek yetmezliği teşhisi ve prognozuna yönelik metotlar ve bileşimler.
US10300108B2 (en) 2013-12-03 2019-05-28 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US11243202B2 (en) 2015-04-09 2022-02-08 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3465201A4 (en) 2016-06-06 2020-08-26 Astute Medical, Inc. MANAGEMENT OF ACUTE KIDNEY DAMAGE USING INSULINOMIMETIC GROWTH FACTOR BINDING PROTEIN 7 AND TISSUE METALLOPROTEINASE 2 INHIBITOR
US11346846B2 (en) 2017-02-06 2022-05-31 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US11718682B2 (en) 2017-04-05 2023-08-08 Astute Medical, Inc. Assays for TIMP2 having improved performance in biological samples
WO2023225626A2 (en) * 2022-05-20 2023-11-23 Adanate, Inc. Multi-targeting lilrb antibodies and uses thereof

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Also Published As

Publication number Publication date
US11718682B2 (en) 2023-08-08
CN110709103B (zh) 2024-02-02
US20200071416A1 (en) 2020-03-05
JP2023145528A (ja) 2023-10-11
EP3606554A4 (en) 2020-12-09
JP2020516603A (ja) 2020-06-11
EP3606554A1 (en) 2020-02-12
WO2018187453A1 (en) 2018-10-11
CN110709103A (zh) 2020-01-17
US20240002529A1 (en) 2024-01-04

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