JP7314059B2 - Ｒｓｖ ｇを発現する組換えキメラウシ／ヒトパラインフルエンザウイルス３およびその使用法 - Google Patents

Ｒｓｖ ｇを発現する組換えキメラウシ／ヒトパラインフルエンザウイルス３およびその使用法 Download PDF

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JP7314059B2
JP7314059B2 JP2019565890A JP2019565890A JP7314059B2 JP 7314059 B2 JP7314059 B2 JP 7314059B2 JP 2019565890 A JP2019565890 A JP 2019565890A JP 2019565890 A JP2019565890 A JP 2019565890A JP 7314059 B2 JP7314059 B2 JP 7314059B2
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hpiv3
amino acid
protein
acid sequence
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JP2020522249A (ja
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ピーター エル． コリンズ
ウルスラ ジェイ． バックホルツ
ボ リアン
シリン ムニル
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    • C12N15/86—Viral vectors
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18571—Demonstrated in vivo effect
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    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
    • C12N2760/18641—Use of virus, viral particle or viral elements as a vector
    • C12N2760/18643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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JP2019565890A 2017-05-29 2018-05-29 Ｒｓｖ ｇを発現する組換えキメラウシ／ヒトパラインフルエンザウイルス３およびその使用法 Active JP7314059B2 (ja)

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JP2023063846A JP2023093566A (ja) 2017-05-29 2023-04-11 Ｒｓｖ ｇを発現する組換えキメラウシ／ヒトパラインフルエンザウイルス３およびその使用法

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US201762512111P 2017-05-29 2017-05-29
US62/512,111 2017-05-29
PCT/US2018/034848 WO2018222573A1 (en) 2017-05-29 2018-05-29 Recombinant chimeric bovine/human parainfluenza virus 3 expressing rsv g and its use

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JP2023063846A Pending JP2023093566A (ja) 2017-05-29 2023-04-11 Ｒｓｖ ｇを発現する組換えキメラウシ／ヒトパラインフルエンザウイルス３およびその使用法

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US (2) US11273214B2 (enExample)
EP (1) EP3630173A1 (enExample)
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CA (1) CA3064267A1 (enExample)
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EP4329797A1 (en) * 2021-04-27 2024-03-06 The United States of America, as represented by the Secretary, Department of Health and Human Services Recombinant chimeric bovine/human parainfluenza virus 3 expressing sars-cov-2 spike protein and its use
MX2024006506A (es) 2021-11-30 2024-08-14 Sanofi Pasteur Inc Vacunas basadas en vectores virales de metapneumovirus humano.
CN115925822B (zh) * 2022-09-01 2024-01-09 广州源博医药科技有限公司 一种重组蛋白及其在制备呼吸道合胞病毒疫苗中的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002502241A (ja) 1997-05-23 2002-01-22 アメリカ合衆国 クローン化されたヌクレオチド配列からの弱毒化パラインフルエンザウィルスワクチンの製造
JP2003516148A (ja) 1999-12-10 2003-05-13 アメリカ合衆国 パラインフルエンザウィルス（ｐｉｖ）及びヒトの病原体により引き起こされる感染及び疾病を保護するためへの組換えｐｉｖのベクターとしての使用
JP2003527122A (ja) 2000-03-21 2003-09-16 アヴィロン 組換えパラインフルエンザウイルス発現系とワクチン
JP2005518209A (ja) 2002-02-21 2005-06-23 マウント シナイ スクール オブ メディシン 組換えマイナス鎖ウイルスｒｎａ発現系およびワクチン
WO2016118642A1 (en) 2015-01-20 2016-07-28 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Recombinant human/bovine parainfluenza virus 3 (b/hpiv3) expressing a chimeric rsv/bpiv3 f protein and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU605476B2 (en) * 1986-01-14 1991-01-17 University Of North Carolina, The Vaccines for human respiratory virus
US7201907B1 (en) 1997-05-23 2007-04-10 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines
US7632508B2 (en) 1997-05-23 2009-12-15 The United States Of America Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines
US7250171B1 (en) 1997-05-23 2007-07-31 United States Of America As Represented By The Dept. Of Health & Human Services Construction and use of recombinant parainfluenza viruses expressing a chimeric glycoprotein
US7192593B2 (en) 1997-05-23 2007-03-20 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Use of recombinant parainfluenza viruses (PIVs) as vectors to protect against infection and disease caused by PIV and other human pathogens
US20030082209A1 (en) 2000-07-05 2003-05-01 Skiadopoulos Mario H. Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines
US7208161B1 (en) 1997-05-23 2007-04-24 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences
TWI344991B (en) 2002-02-21 2011-07-11 Medimmune Vaccines Inc Metapneumovirus strains as vaccine formulations and as vectors for expression of heterologous antigenic sequences
US20050142148A1 (en) 2003-04-25 2005-06-30 Fouchier Ronaldus A.M. Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus
US9216212B2 (en) * 2005-08-05 2015-12-22 University Of Massachusetts Virus-like particles as vaccines for paramyxovirus
US20090017517A1 (en) 2007-07-13 2009-01-15 Medimmune, Llc Preparation of Negative-Stranded RNA Viruses by Electroporation
KR102854980B1 (ko) * 2015-12-11 2025-09-03 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 약독화 표현형의 범위를 제공하는 m2-2 orf 변이를 가지는 재조합 호흡기 세포융합 바이러스 균주

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002502241A (ja) 1997-05-23 2002-01-22 アメリカ合衆国 クローン化されたヌクレオチド配列からの弱毒化パラインフルエンザウィルスワクチンの製造
JP2003516148A (ja) 1999-12-10 2003-05-13 アメリカ合衆国 パラインフルエンザウィルス（ｐｉｖ）及びヒトの病原体により引き起こされる感染及び疾病を保護するためへの組換えｐｉｖのベクターとしての使用
JP2003527122A (ja) 2000-03-21 2003-09-16 アヴィロン 組換えパラインフルエンザウイルス発現系とワクチン
JP2005518209A (ja) 2002-02-21 2005-06-23 マウント シナイ スクール オブ メディシン 組換えマイナス鎖ウイルスｒｎａ発現系およびワクチン
WO2016118642A1 (en) 2015-01-20 2016-07-28 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Recombinant human/bovine parainfluenza virus 3 (b/hpiv3) expressing a chimeric rsv/bpiv3 f protein and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Bo Liang et al.，Journal of Virology，2014年04月，Vol 88, No. 8，p. 4237-4250
Bo Liang et al.，Journal of Virology，2015年09月，Vol. 89, No. 18，p. 9499-9510
Bo Liang et al.，Journal of Virology，2019年03月21日，Vol. 93, Issue 7，e02043-18, p. 1-23

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US11273214B2 (en) 2022-03-15
JP2023093566A (ja) 2023-07-04
JP2020522249A (ja) 2020-07-30
WO2018222573A1 (en) 2018-12-06
US20220226458A1 (en) 2022-07-21
US20210145958A1 (en) 2021-05-20
CN110996998A (zh) 2020-04-10
CA3064267A1 (en) 2018-12-06
US11975063B2 (en) 2024-05-07
EP3630173A1 (en) 2020-04-08

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