JP7297901B2 - 歯のエナメル質の脱灰に耐えるための鉱化材料及びその応用 - Google Patents
歯のエナメル質の脱灰に耐えるための鉱化材料及びその応用 Download PDFInfo
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- JP7297901B2 JP7297901B2 JP2021538438A JP2021538438A JP7297901B2 JP 7297901 B2 JP7297901 B2 JP 7297901B2 JP 2021538438 A JP2021538438 A JP 2021538438A JP 2021538438 A JP2021538438 A JP 2021538438A JP 7297901 B2 JP7297901 B2 JP 7297901B2
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- tooth enamel
- sodium
- demineralization
- phosphate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
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- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
Claims (8)
- 下記の質量パーセントの成分:
膜形成タンパク質5%~50%、アメロゲニン5%~40%、水溶性リン酸塩5%~30%、トリス(2-カルボキシエチル)ホスフィン塩酸塩4%~20%、pH調整剤の1%~10%、を含み、
前記膜形成タンパク質はリゾチーム、ウシ血清アルブミン、インスリン及びα-ラクトアルブミンのいずれかまたは複数であり、
前記pH調整剤は炭酸ナトリウム、炭酸水素ナトリウム、炭酸カリウム、炭酸水素カリウム、リン酸水素二カリウム、二塩基性リン酸ナトリウム、安息香酸ナトリウム及びクエン酸ナトリウムのいずれかまたは複数であることを特徴とする歯のエナメル質の脱灰に耐えるための鉱化材料。 - 前記鉱化材料が下記の質量パーセントの成分:
膜形成タンパク質20%~40%、アメロゲニン20%~30%、水溶性リン酸塩20%~30%、トリス(2-カルボキシエチル)ホスフィン塩酸塩10%~15%、pH調整剤6%~8%を含むことを特徴とする請求項1に記載の歯のエナメル質の脱灰に耐えるための鉱化材料。 - 前記水溶性リン酸塩は二塩基性リン酸ナトリウム及びリン酸二水素ナトリウムのいずれかまたは2種であることを特徴とする請求項1または2に記載の歯のエナメル質の脱灰に耐えるための鉱化材料。
- 請求項1に記載の鉱化材料及び超純水で希釈されたHEPESバッファ液を、質量体積比1mg:4~15mLで含むことを特徴とする嗽液。
- 前記嗽液はpH値が7~7.5であることを特徴とする請求項4に記載の嗽液。
- 前記嗽液にサッカリンナトリウム及びソルボースも含有することを特徴とする請求項4に記載の嗽液。
- 請求項1に記載の鉱化材料及び練り歯磨きを作るための補助的材料を、質量比1:2~5で含むことを特徴とする練り歯磨き。
- 前記補助的材料は摩擦剤、保湿剤、増粘剤、防腐剤、色素及び香料エッセンスのいずれかまたは複数であることを特徴とする請求項7に記載の練り歯磨き。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN201811650996.5 | 2018-12-31 | ||
CN201811650996.5A CN111000747B (zh) | 2018-12-31 | 2018-12-31 | 一种防牙釉质脱矿的矿化材料及其应用 |
PCT/CN2019/124584 WO2020140706A1 (zh) | 2018-12-31 | 2019-12-11 | 一种防牙釉质脱矿的矿化材料及其应用 |
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JP2022516147A JP2022516147A (ja) | 2022-02-24 |
JP7297901B2 true JP7297901B2 (ja) | 2023-06-26 |
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JP2021538438A Active JP7297901B2 (ja) | 2018-12-31 | 2019-12-11 | 歯のエナメル質の脱灰に耐えるための鉱化材料及びその応用 |
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US (1) | US11701320B2 (ja) |
JP (1) | JP7297901B2 (ja) |
CN (1) | CN111000747B (ja) |
WO (1) | WO2020140706A1 (ja) |
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CN112716812B (zh) * | 2021-01-11 | 2023-03-10 | 天津医科大学口腔医院 | 一种用于根管冲洗和阻断治疗牙本质龋的抗生物膜-再矿化材料及其制备方法 |
EP4340949A1 (en) | 2021-05-20 | 2024-03-27 | Smile Makers, LLC | Oral hygiene compositions and methods of use |
CN113209358A (zh) * | 2021-05-21 | 2021-08-06 | 上海交通大学医学院附属第九人民医院 | 组织粘合剂及其制备方法和用途 |
WO2023142882A1 (zh) * | 2022-01-28 | 2023-08-03 | 陕西师范大学 | 一种用于治疗牙敏感以及促进牙釉质外延生长的矿化材料及其应用 |
CN114903893A (zh) * | 2022-06-21 | 2022-08-16 | 陕西师范大学 | 用于预防和阻断继发龋的抗生物膜-再矿化材料及其制备方法和应用 |
CN115844737A (zh) * | 2022-12-31 | 2023-03-28 | 广西信业生物技术有限公司 | 一种牙釉质钙修复生物活性矿物质材料的制备方法 |
CN116115823A (zh) * | 2023-02-08 | 2023-05-16 | 陕西师范大学 | 一种有机无机复合材料及其制备方法 |
Citations (5)
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JP2006076980A (ja) | 2004-09-13 | 2006-03-23 | National Institute For Materials Science | 歯の再生材料とこれを利用した歯の再生方法 |
US20080152598A1 (en) | 2003-04-17 | 2008-06-26 | Producta Ltd. | Oral composition for stabilization, (re)calcification and (re)mineralization of tooth enamel and dentine |
JP2012167040A (ja) | 2011-02-10 | 2012-09-06 | Hiroshima Univ | エナメル質再生液及びエナメル質再生キット |
JP2013177368A (ja) | 2012-01-30 | 2013-09-09 | Hiroshima Univ | ヒトアメロゲニン部分ペプチド |
US20140186273A1 (en) | 2012-12-27 | 2014-07-03 | University Of Southern California | Chitosan -Amelogenin Hydrogel for In Situ Enamel Growth |
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US6677306B1 (en) * | 1998-07-29 | 2004-01-13 | Northwestern University | Chondrogenic and osteogenic inducing molecule |
US8071131B2 (en) * | 2004-07-15 | 2011-12-06 | Ivoclar Vivadent, Inc. | Mineralizing composite materials for restoring teeth |
AU2006346493B2 (en) * | 2005-11-14 | 2012-02-02 | Louisiana Tech University Research Foundation | Polypeptide films and methods |
RU2673820C2 (ru) * | 2013-09-25 | 2018-11-30 | Кредентис Аг | Стоматологический продукт для отбеливания зубов |
CN105769609B (zh) * | 2014-12-23 | 2018-11-06 | 安徽绿微康生物科技有限公司 | 具有抗菌、除斑和美白功能的牙膏组合物 |
CN105153443B (zh) * | 2015-08-27 | 2018-01-12 | 陕西师范大学 | 利用溶菌酶制备的生物蛋白质二维纳米薄膜及其制备方法 |
WO2017123986A1 (en) * | 2016-01-13 | 2017-07-20 | University Of Washington | Reagents and methods for mineralization of tooth enamel |
CN106511112B (zh) * | 2016-12-13 | 2019-10-18 | 美晨集团股份有限公司 | 一种持久清凉抑菌的牙膏及其制备方法 |
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- 2019-12-11 WO PCT/CN2019/124584 patent/WO2020140706A1/zh active Application Filing
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Patent Citations (5)
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US20080152598A1 (en) | 2003-04-17 | 2008-06-26 | Producta Ltd. | Oral composition for stabilization, (re)calcification and (re)mineralization of tooth enamel and dentine |
JP2006076980A (ja) | 2004-09-13 | 2006-03-23 | National Institute For Materials Science | 歯の再生材料とこれを利用した歯の再生方法 |
JP2012167040A (ja) | 2011-02-10 | 2012-09-06 | Hiroshima Univ | エナメル質再生液及びエナメル質再生キット |
JP2013177368A (ja) | 2012-01-30 | 2013-09-09 | Hiroshima Univ | ヒトアメロゲニン部分ペプチド |
US20140186273A1 (en) | 2012-12-27 | 2014-07-03 | University Of Southern California | Chitosan -Amelogenin Hydrogel for In Situ Enamel Growth |
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CN111000747B (zh) | 2021-06-15 |
US20210322292A1 (en) | 2021-10-21 |
WO2020140706A1 (zh) | 2020-07-09 |
US11701320B2 (en) | 2023-07-18 |
JP2022516147A (ja) | 2022-02-24 |
CN111000747A (zh) | 2020-04-14 |
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