JP7292568B2 - ヒアルロニダーゼ阻害剤、並びにこれを配合してなる化粧料組成物及び機能性食品 - Google Patents
ヒアルロニダーゼ阻害剤、並びにこれを配合してなる化粧料組成物及び機能性食品 Download PDFInfo
- Publication number
- JP7292568B2 JP7292568B2 JP2017069556A JP2017069556A JP7292568B2 JP 7292568 B2 JP7292568 B2 JP 7292568B2 JP 2017069556 A JP2017069556 A JP 2017069556A JP 2017069556 A JP2017069556 A JP 2017069556A JP 7292568 B2 JP7292568 B2 JP 7292568B2
- Authority
- JP
- Japan
- Prior art keywords
- koji
- rice
- hyaluronidase
- present
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims description 29
- 239000002537 cosmetic Substances 0.000 title claims description 26
- 229940122393 Hyaluronidase inhibitor Drugs 0.000 title claims description 21
- 235000013376 functional food Nutrition 0.000 title claims description 18
- 241000209094 Oryza Species 0.000 claims description 88
- 235000007164 Oryza sativa Nutrition 0.000 claims description 88
- 235000009566 rice Nutrition 0.000 claims description 88
- 240000006439 Aspergillus oryzae Species 0.000 claims description 57
- 235000002247 Aspergillus oryzae Nutrition 0.000 claims description 57
- 239000000284 extract Substances 0.000 claims description 50
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 43
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims description 15
- 241001513093 Aspergillus awamori Species 0.000 claims description 10
- 230000005764 inhibitory process Effects 0.000 claims description 10
- 241000122821 Aspergillus kawachii Species 0.000 claims description 9
- 230000000644 propagated effect Effects 0.000 claims description 8
- 239000003963 antioxidant agent Substances 0.000 claims description 3
- 230000003712 anti-aging effect Effects 0.000 claims 2
- 230000011382 collagen catabolic process Effects 0.000 claims 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 45
- 102000001974 Hyaluronidases Human genes 0.000 description 45
- 229960002773 hyaluronidase Drugs 0.000 description 45
- 239000000047 product Substances 0.000 description 40
- 239000002904 solvent Substances 0.000 description 40
- 230000000694 effects Effects 0.000 description 24
- 238000000605 extraction Methods 0.000 description 21
- 239000003112 inhibitor Substances 0.000 description 19
- 230000002401 inhibitory effect Effects 0.000 description 17
- 235000013305 food Nutrition 0.000 description 15
- 239000000243 solution Substances 0.000 description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 9
- 238000001035 drying Methods 0.000 description 9
- 229920002674 hyaluronan Polymers 0.000 description 9
- 229960003160 hyaluronic acid Drugs 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 8
- 238000002156 mixing Methods 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 235000019441 ethanol Nutrition 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 210000003491 skin Anatomy 0.000 description 6
- 241000228212 Aspergillus Species 0.000 description 5
- 235000013361 beverage Nutrition 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 229940058015 1,3-butylene glycol Drugs 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 235000019437 butane-1,3-diol Nutrition 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- -1 aliphatic ketones Chemical class 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000009759 skin aging Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 239000013040 bath agent Substances 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 235000015110 jellies Nutrition 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 235000013772 propylene glycol Nutrition 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 239000002453 shampoo Substances 0.000 description 2
- 235000020083 shōchū Nutrition 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- BGNGWHSBYQYVRX-UHFFFAOYSA-N 4-(dimethylamino)benzaldehyde Chemical compound CN(C)C1=CC=C(C=O)C=C1 BGNGWHSBYQYVRX-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
- 239000004278 EU approved seasoning Substances 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 244000025221 Humulus lupulus Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000020060 Increased inflammatory response Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 244000090599 Plantago psyllium Species 0.000 description 1
- 235000010451 Plantago psyllium Nutrition 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000005158 Thymus praecox ssp. arcticus Nutrition 0.000 description 1
- 240000006001 Thymus serpyllum Species 0.000 description 1
- 235000004054 Thymus serpyllum Nutrition 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000013334 alcoholic beverage Nutrition 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000020054 awamori Nutrition 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 235000021329 brown rice Nutrition 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
- 229940110767 coenzyme Q10 Drugs 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 229920002055 compound 48/80 Polymers 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229940038487 grape extract Drugs 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
- 235000014102 seafood Nutrition 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Images
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017069556A JP7292568B2 (ja) | 2015-10-08 | 2017-03-31 | ヒアルロニダーゼ阻害剤、並びにこれを配合してなる化粧料組成物及び機能性食品 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015200454A JP6159918B2 (ja) | 2015-10-08 | 2015-10-08 | ヒアルロニダーゼ阻害剤及びヒアルロニダーゼの活性を阻害する方法 |
| JP2017069556A JP7292568B2 (ja) | 2015-10-08 | 2017-03-31 | ヒアルロニダーゼ阻害剤、並びにこれを配合してなる化粧料組成物及び機能性食品 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015200454A Division JP6159918B2 (ja) | 2015-10-08 | 2015-10-08 | ヒアルロニダーゼ阻害剤及びヒアルロニダーゼの活性を阻害する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017122122A JP2017122122A (ja) | 2017-07-13 |
| JP2017122122A5 JP2017122122A5 (https=) | 2018-11-08 |
| JP7292568B2 true JP7292568B2 (ja) | 2023-06-19 |
Family
ID=86772613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017069556A Active JP7292568B2 (ja) | 2015-10-08 | 2017-03-31 | ヒアルロニダーゼ阻害剤、並びにこれを配合してなる化粧料組成物及び機能性食品 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP7292568B2 (https=) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001151788A (ja) | 1999-09-13 | 2001-06-05 | Toyama Prefecture | 海洋性微細藻の培養方法とその抽出物を有効成分とするヒアルロニダーゼ阻害物質並びに薬剤、化粧品及び食品 |
| JP2002255784A (ja) | 2001-03-02 | 2002-09-11 | Oriza Yuka Kk | 美肌用組成物 |
| JP2002293740A (ja) | 2001-03-30 | 2002-10-09 | Sansho Seiyaku Co Ltd | ヒアルロニダーゼ活性阻害剤 |
| JP2003252778A (ja) | 2002-02-27 | 2003-09-10 | Showa Sangyo Co Ltd | ヒアルロニダーゼ阻害剤及び該剤を含有する化粧品、飲食品又は医薬品 |
| JP2004189698A (ja) | 2002-12-13 | 2004-07-08 | Nichirei Corp | 美白剤、抗酸化剤、コラゲナーゼ活性阻害剤、ヒアルロニダーゼ活性阻害剤、老化防止剤、皮膚外用剤、化粧料及び食料品 |
| JP2015140325A (ja) | 2014-01-30 | 2015-08-03 | 福岡県 | コラゲナーゼ阻害剤、並びにコラゲナーゼ阻害剤を配合した化粧料組成物及び機能性食品 |
| JP6159918B2 (ja) | 2015-10-08 | 2017-07-12 | 福岡県 | ヒアルロニダーゼ阻害剤及びヒアルロニダーゼの活性を阻害する方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003073287A (ja) * | 2001-08-30 | 2003-03-12 | Ichimaru Pharcos Co Ltd | ヒアルロニダーゼ活性阻害剤又は化粧料組成物 |
| JP2006062984A (ja) * | 2004-08-25 | 2006-03-09 | Yukihiro Hirose | 老化防止組成物およびそれを含有する化粧料ならびに飲食品 |
-
2017
- 2017-03-31 JP JP2017069556A patent/JP7292568B2/ja active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001151788A (ja) | 1999-09-13 | 2001-06-05 | Toyama Prefecture | 海洋性微細藻の培養方法とその抽出物を有効成分とするヒアルロニダーゼ阻害物質並びに薬剤、化粧品及び食品 |
| JP2002255784A (ja) | 2001-03-02 | 2002-09-11 | Oriza Yuka Kk | 美肌用組成物 |
| JP2002293740A (ja) | 2001-03-30 | 2002-10-09 | Sansho Seiyaku Co Ltd | ヒアルロニダーゼ活性阻害剤 |
| JP2003252778A (ja) | 2002-02-27 | 2003-09-10 | Showa Sangyo Co Ltd | ヒアルロニダーゼ阻害剤及び該剤を含有する化粧品、飲食品又は医薬品 |
| JP2004189698A (ja) | 2002-12-13 | 2004-07-08 | Nichirei Corp | 美白剤、抗酸化剤、コラゲナーゼ活性阻害剤、ヒアルロニダーゼ活性阻害剤、老化防止剤、皮膚外用剤、化粧料及び食料品 |
| JP2015140325A (ja) | 2014-01-30 | 2015-08-03 | 福岡県 | コラゲナーゼ阻害剤、並びにコラゲナーゼ阻害剤を配合した化粧料組成物及び機能性食品 |
| JP6159918B2 (ja) | 2015-10-08 | 2017-07-12 | 福岡県 | ヒアルロニダーゼ阻害剤及びヒアルロニダーゼの活性を阻害する方法 |
Non-Patent Citations (1)
| Title |
|---|
| 池田浩二著，"米麹を添加した芋焼酎粕飲料の機能性に関する研究"，鹿児島大学リポジトリ，２０１２年 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017122122A (ja) | 2017-07-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5538611B2 (ja) | メイラード反応阻害剤 | |
| CN113694115A (zh) | 一种茯茶提取物在制备皮肤调节产品中的用途 | |
| JP5714869B2 (ja) | 糖不含有パイナップル抽出物、及びその製造方法、並びにその用途 | |
| JP6055667B2 (ja) | コラーゲン産生促進剤 | |
| EP2200574B1 (en) | Novel use of panduratin derivatives or extract of kaempferia pandurata comprising the same | |
| TW201210633A (en) | Agent for promoting hyaluronic acid production | |
| JP2011201788A (ja) | 抗炎症剤 | |
| JP6159918B2 (ja) | ヒアルロニダーゼ阻害剤及びヒアルロニダーゼの活性を阻害する方法 | |
| JP2006306804A (ja) | シワ形成抑制剤 | |
| JP2012041276A (ja) | タンパク質のカルボニル化抑制剤及び肌の透明感向上剤 | |
| JP4672269B2 (ja) | 抗老化剤、血小板凝集抑制剤、抗酸化剤、抗アレルギー剤、皮膚化粧料及び飲食品 | |
| JP5534654B2 (ja) | 抗炎症剤 | |
| JP6411403B2 (ja) | 蛋白質糖化反応阻害剤 | |
| JP5220346B2 (ja) | 皮膚化粧料 | |
| JP5512067B2 (ja) | 皮膚化粧料 | |
| JP7292568B2 (ja) | ヒアルロニダーゼ阻害剤、並びにこれを配合してなる化粧料組成物及び機能性食品 | |
| JP6122200B1 (ja) | 抗糖化用組成物 | |
| JP4247091B2 (ja) | 皮膚老化防止剤 | |
| JP6544503B2 (ja) | コラゲナーゼ阻害剤、並びにコラゲナーゼ阻害剤を配合した化粧料組成物及び機能性食品 | |
| JP2020143034A (ja) | メイラード反応阻害剤およびＡＧＥｓ架橋切断促進剤 | |
| JP2012067061A (ja) | メイラード反応阻害剤及び老化改善剤 | |
| JP7013645B2 (ja) | リパーゼ活性阻害剤 | |
| JP2009298711A (ja) | 美白剤、並びに、皮膚外用剤及び飲食品 | |
| KR20140130401A (ko) | 항산화능이 향상된 동아 추출물 제조방법 | |
| JP4034984B2 (ja) | 抗酸化組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20171011 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180928 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20180928 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20180928 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20191008 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20191206 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200526 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200721 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20200721 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20201222 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210322 |
|
| C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20210322 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20210322 |
|
| C11 | Written invitation by the commissioner to file amendments |
Free format text: JAPANESE INTERMEDIATE CODE: C11 Effective date: 20210525 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20210625 |
|
| C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20210706 |
|
| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20210903 |
|
| C211 | Notice of termination of reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C211 Effective date: 20210907 |
|
| C22 | Notice of designation (change) of administrative judge |
Free format text: JAPANESE INTERMEDIATE CODE: C22 Effective date: 20220426 |
|
| C22 | Notice of designation (change) of administrative judge |
Free format text: JAPANESE INTERMEDIATE CODE: C22 Effective date: 20220816 |
|
| C23 | Notice of termination of proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C23 Effective date: 20230228 |
|
| C03 | Trial/appeal decision taken |
Free format text: JAPANESE INTERMEDIATE CODE: C03 Effective date: 20230411 |
|
| C30A | Notification sent |
Free format text: JAPANESE INTERMEDIATE CODE: C3012 Effective date: 20230411 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20230428 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7292568 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |