JP7289061B2 - シミュレーションベースの薬物処置計画 - Google Patents
シミュレーションベースの薬物処置計画 Download PDFInfo
- Publication number
- JP7289061B2 JP7289061B2 JP2019571961A JP2019571961A JP7289061B2 JP 7289061 B2 JP7289061 B2 JP 7289061B2 JP 2019571961 A JP2019571961 A JP 2019571961A JP 2019571961 A JP2019571961 A JP 2019571961A JP 7289061 B2 JP7289061 B2 JP 7289061B2
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- Prior art keywords
- target
- sonication
- treatment
- target bbb
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasonic imaging preparations
- A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0693—Brain, cerebrum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0021—Neural system treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0039—Ultrasound therapy using microbubbles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0073—Ultrasound therapy using multiple frequencies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0078—Ultrasound therapy with multiple treatment transducers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0082—Scanning transducers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0086—Beam steering
- A61N2007/0095—Beam steering by modifying an excitation signal
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762526545P | 2017-06-29 | 2017-06-29 | |
| US201762526550P | 2017-06-29 | 2017-06-29 | |
| US201762526548P | 2017-06-29 | 2017-06-29 | |
| US62/526,550 | 2017-06-29 | ||
| US15/637,163 US11123575B2 (en) | 2017-06-29 | 2017-06-29 | 3D conformal radiation therapy with reduced tissue stress and improved positional tolerance |
| US62/526,545 | 2017-06-29 | ||
| US15/637,163 | 2017-06-29 | ||
| US62/526,548 | 2017-06-29 | ||
| US201762597076P | 2017-12-11 | 2017-12-11 | |
| US201762597073P | 2017-12-11 | 2017-12-11 | |
| US62/597,076 | 2017-12-11 | ||
| US62/597,073 | 2017-12-11 | ||
| PCT/IB2018/000834 WO2019002943A1 (en) | 2017-06-29 | 2018-06-29 | SIMULATION-BASED TREATMENT PLANNING BASED ON SIMULATION |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020525169A JP2020525169A (ja) | 2020-08-27 |
| JP2020525169A5 JP2020525169A5 (https=) | 2021-07-26 |
| JP7289061B2 true JP7289061B2 (ja) | 2023-06-09 |
Family
ID=63364094
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019571961A Active JP7289061B2 (ja) | 2017-06-29 | 2018-06-29 | シミュレーションベースの薬物処置計画 |
| JP2019571959A Pending JP2020525167A (ja) | 2017-06-29 | 2018-06-29 | キャビテーション強化型の標的化薬物送達および投与 |
| JP2019571960A Active JP7232204B2 (ja) | 2017-06-29 | 2018-06-29 | マイクロバブル強化超音波処置における超音波周波数およびマイクロバブルサイズの最適化 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019571959A Pending JP2020525167A (ja) | 2017-06-29 | 2018-06-29 | キャビテーション強化型の標的化薬物送達および投与 |
| JP2019571960A Active JP7232204B2 (ja) | 2017-06-29 | 2018-06-29 | マイクロバブル強化超音波処置における超音波周波数およびマイクロバブルサイズの最適化 |
Country Status (4)
| Country | Link |
|---|---|
| EP (3) | EP3645117B1 (https=) |
| JP (3) | JP7289061B2 (https=) |
| CN (3) | CN111032157B (https=) |
| WO (3) | WO2019002947A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11123575B2 (en) | 2017-06-29 | 2021-09-21 | Insightec, Ltd. | 3D conformal radiation therapy with reduced tissue stress and improved positional tolerance |
| JP2022510654A (ja) | 2018-11-28 | 2022-01-27 | ヒストソニックス,インコーポレーテッド | 組織破砕システムおよび方法 |
| US20220161013A1 (en) * | 2019-04-04 | 2022-05-26 | Northwestern University | Improved delivery of drug therapy to the cns by ultrasound-based opening of the blood-brain barrier |
| US11730452B2 (en) * | 2019-04-09 | 2023-08-22 | Insightec Ltd. | Systems and methods for regulating microbubbles in ultrasound procedures |
| US12409345B2 (en) | 2019-07-25 | 2025-09-09 | Insightec Ltd. | Aberration corrections for dynamically changing media during ultrasound therapy |
| CA3169465A1 (en) | 2020-01-28 | 2021-08-05 | The Regents Of The University Of Michigan | Systems and methods for histotripsy immunosensitization |
| US12582386B2 (en) | 2020-03-05 | 2026-03-24 | Insightec Ltd. | Differential prediction of aberration corrections for ultrasound therapy |
| BR112022025722A2 (pt) | 2020-06-18 | 2023-03-07 | Histosonics Inc | Sistemas e métodos de acoplamento acústico e paciente de histotripsia |
| CA3190517A1 (en) | 2020-08-27 | 2022-03-03 | Timothy Lewis HALL | Ultrasound transducer with transmit-receive capability for histotripsy |
| WO2022260746A1 (en) | 2021-06-07 | 2022-12-15 | The Regents Of The University Of Michigan | Minimally invasive histotripsy systems and methods |
| IL308943A (en) | 2021-06-07 | 2024-01-01 | Univ Michigan Regents | All-inclusive ultrasound systems and methods that include histotripsy |
| US20250263798A1 (en) | 2021-07-01 | 2025-08-21 | Insightec Ltd. | Diagnostic and treatment monitoring based on blood-brain barrier disruption |
| CN113714070B (zh) * | 2021-07-26 | 2022-05-24 | 中北大学 | 混合振膜结构宽频带电容式微机械超声换能器设计方法 |
| WO2023180811A2 (en) * | 2022-03-22 | 2023-09-28 | Insightec Ltd. | Monitoring tissue permeability during ultrasound procedures |
| WO2024047580A1 (en) * | 2022-08-31 | 2024-03-07 | Insightec Ltd. | Enforced tissue residency of payload molecules by acoustic disruption |
| EP4608504A1 (en) | 2022-10-28 | 2025-09-03 | Histosonics, Inc. | Histotripsy systems and methods |
| KR102626932B1 (ko) * | 2023-01-03 | 2024-01-23 | 주식회사 뉴머스 | 환자 맞춤형 헬멧 및 이의 제조 방법 |
| KR20260003742A (ko) | 2023-04-20 | 2026-01-07 | 히스토소닉스, 인크. | 치료 계획 및 요법을 위한 사용자 인터페이스들 및 작업 흐름들을 포함하는 히스토트립시 시스템들 및 연관된 방법들 |
| WO2024257021A1 (en) * | 2023-06-13 | 2024-12-19 | Insightec Ltd. | Tissue type-based blood-brain barrier opening and treatment parameter establishment systems thereof |
| KR102932441B1 (ko) * | 2024-08-29 | 2026-02-27 | 주식회사 뉴머스 | 병리생리학적 상태에 기반한 음향공동화현상 발생 임계값 조절을 통한 뇌-혈관 장벽 제어 시스템 및 그 구동방법 |
Citations (4)
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| JP2011529039A (ja) | 2008-07-23 | 2011-12-01 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 超音波仲介による薬送達 |
| JP2012524596A (ja) | 2009-04-23 | 2012-10-18 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | 鼻気流式デバイスコントローラ |
| US20130046229A1 (en) | 2008-03-19 | 2013-02-21 | The Trustees Of Columbia University In The City Of New York | Systems and methods for opening of a tissue barrier |
| JP2016509506A (ja) | 2013-01-29 | 2016-03-31 | インサイテック・リミテッド | シミュレーションベース集束超音波治療計画 |
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| CN101698121B (zh) * | 2009-10-23 | 2011-06-22 | 西安交通大学 | 促进药物透过血脑屏障的适型超声系统 |
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| KR101657285B1 (ko) * | 2015-05-13 | 2016-09-19 | 조선대학교산학협력단 | 초음파 치료 시뮬레이션시스템 |
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-
2018
- 2018-06-29 CN CN201880056389.8A patent/CN111032157B/zh active Active
- 2018-06-29 WO PCT/IB2018/000841 patent/WO2019002947A1/en not_active Ceased
- 2018-06-29 WO PCT/IB2018/000811 patent/WO2019002940A1/en not_active Ceased
- 2018-06-29 JP JP2019571961A patent/JP7289061B2/ja active Active
- 2018-06-29 JP JP2019571959A patent/JP2020525167A/ja active Pending
- 2018-06-29 JP JP2019571960A patent/JP7232204B2/ja active Active
- 2018-06-29 EP EP18768933.6A patent/EP3645117B1/en active Active
- 2018-06-29 WO PCT/IB2018/000834 patent/WO2019002943A1/en not_active Ceased
- 2018-06-29 EP EP18765703.6A patent/EP3645116B1/en active Active
- 2018-06-29 EP EP18759374.4A patent/EP3645118B1/en active Active
- 2018-06-29 CN CN201880043567.3A patent/CN110831665B/zh active Active
- 2018-06-29 CN CN201880043399.8A patent/CN111132732B/zh active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130046229A1 (en) | 2008-03-19 | 2013-02-21 | The Trustees Of Columbia University In The City Of New York | Systems and methods for opening of a tissue barrier |
| JP2011529039A (ja) | 2008-07-23 | 2011-12-01 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 超音波仲介による薬送達 |
| JP2012524596A (ja) | 2009-04-23 | 2012-10-18 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | 鼻気流式デバイスコントローラ |
| JP2016509506A (ja) | 2013-01-29 | 2016-03-31 | インサイテック・リミテッド | シミュレーションベース集束超音波治療計画 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3645116B1 (en) | 2021-07-28 |
| JP2020525168A (ja) | 2020-08-27 |
| EP3645116A1 (en) | 2020-05-06 |
| CN110831665A (zh) | 2020-02-21 |
| EP3645117A1 (en) | 2020-05-06 |
| JP2020525169A (ja) | 2020-08-27 |
| WO2019002947A8 (en) | 2020-04-02 |
| EP3645118B1 (en) | 2023-11-29 |
| CN111032157A (zh) | 2020-04-17 |
| EP3645117B1 (en) | 2021-07-28 |
| CN111132732A (zh) | 2020-05-08 |
| WO2019002947A1 (en) | 2019-01-03 |
| CN110831665B (zh) | 2022-03-04 |
| WO2019002940A1 (en) | 2019-01-03 |
| JP2020525167A (ja) | 2020-08-27 |
| EP3645118A1 (en) | 2020-05-06 |
| JP7232204B2 (ja) | 2023-03-02 |
| CN111132732B (zh) | 2021-09-21 |
| EP3645118C0 (en) | 2023-11-29 |
| CN111032157B (zh) | 2023-04-21 |
| WO2019002943A1 (en) | 2019-01-03 |
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