JP7289061B2 - シミュレーションベースの薬物処置計画 - Google Patents
シミュレーションベースの薬物処置計画 Download PDFInfo
- Publication number
- JP7289061B2 JP7289061B2 JP2019571961A JP2019571961A JP7289061B2 JP 7289061 B2 JP7289061 B2 JP 7289061B2 JP 2019571961 A JP2019571961 A JP 2019571961A JP 2019571961 A JP2019571961 A JP 2019571961A JP 7289061 B2 JP7289061 B2 JP 7289061B2
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- sonication
- treatment
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0693—Brain, cerebrum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0021—Neural system treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0039—Ultrasound therapy using microbubbles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0073—Ultrasound therapy using multiple frequencies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0078—Ultrasound therapy with multiple treatment transducers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0082—Scanning transducers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0086—Beam steering
- A61N2007/0095—Beam steering by modifying an excitation signal
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762526545P | 2017-06-29 | 2017-06-29 | |
| US201762526550P | 2017-06-29 | 2017-06-29 | |
| US201762526548P | 2017-06-29 | 2017-06-29 | |
| US62/526,548 | 2017-06-29 | ||
| US62/526,545 | 2017-06-29 | ||
| US62/526,550 | 2017-06-29 | ||
| US15/637,163 US11123575B2 (en) | 2017-06-29 | 2017-06-29 | 3D conformal radiation therapy with reduced tissue stress and improved positional tolerance |
| US15/637,163 | 2017-06-29 | ||
| US201762597073P | 2017-12-11 | 2017-12-11 | |
| US201762597076P | 2017-12-11 | 2017-12-11 | |
| US62/597,076 | 2017-12-11 | ||
| US62/597,073 | 2017-12-11 | ||
| PCT/IB2018/000834 WO2019002943A1 (en) | 2017-06-29 | 2018-06-29 | SIMULATION-BASED TREATMENT PLANNING BASED ON SIMULATION |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020525169A JP2020525169A (ja) | 2020-08-27 |
| JP2020525169A5 JP2020525169A5 (enExample) | 2021-07-26 |
| JP7289061B2 true JP7289061B2 (ja) | 2023-06-09 |
Family
ID=63364094
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019571961A Active JP7289061B2 (ja) | 2017-06-29 | 2018-06-29 | シミュレーションベースの薬物処置計画 |
| JP2019571960A Active JP7232204B2 (ja) | 2017-06-29 | 2018-06-29 | マイクロバブル強化超音波処置における超音波周波数およびマイクロバブルサイズの最適化 |
| JP2019571959A Pending JP2020525167A (ja) | 2017-06-29 | 2018-06-29 | キャビテーション強化型の標的化薬物送達および投与 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019571960A Active JP7232204B2 (ja) | 2017-06-29 | 2018-06-29 | マイクロバブル強化超音波処置における超音波周波数およびマイクロバブルサイズの最適化 |
| JP2019571959A Pending JP2020525167A (ja) | 2017-06-29 | 2018-06-29 | キャビテーション強化型の標的化薬物送達および投与 |
Country Status (4)
| Country | Link |
|---|---|
| EP (3) | EP3645116B1 (enExample) |
| JP (3) | JP7289061B2 (enExample) |
| CN (3) | CN111132732B (enExample) |
| WO (3) | WO2019002940A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11123575B2 (en) | 2017-06-29 | 2021-09-21 | Insightec, Ltd. | 3D conformal radiation therapy with reduced tissue stress and improved positional tolerance |
| AU2019389001B2 (en) | 2018-11-28 | 2025-08-14 | Histosonics, Inc. | Histotripsy systems and methods |
| US20220161013A1 (en) * | 2019-04-04 | 2022-05-26 | Northwestern University | Improved delivery of drug therapy to the cns by ultrasound-based opening of the blood-brain barrier |
| US11730452B2 (en) * | 2019-04-09 | 2023-08-22 | Insightec Ltd. | Systems and methods for regulating microbubbles in ultrasound procedures |
| US12409345B2 (en) | 2019-07-25 | 2025-09-09 | Insightec Ltd. | Aberration corrections for dynamically changing media during ultrasound therapy |
| AU2021213168A1 (en) | 2020-01-28 | 2022-09-01 | The Regents Of The University Of Michigan | Systems and methods for histotripsy immunosensitization |
| EP4114519A1 (en) | 2020-03-05 | 2023-01-11 | Insightec, Ltd. | Differential prediction of aberration corrections for ultrasound therapy |
| IL300851A (en) | 2020-08-27 | 2023-04-01 | Univ Michigan Regents | Ultrasonic transducer with transmit-receive capability for focused ultrasound |
| US20250263798A1 (en) | 2021-07-01 | 2025-08-21 | Insightec Ltd. | Diagnostic and treatment monitoring based on blood-brain barrier disruption |
| CN113714070B (zh) * | 2021-07-26 | 2022-05-24 | 中北大学 | 混合振膜结构宽频带电容式微机械超声换能器设计方法 |
| EP4496618A2 (en) * | 2022-03-22 | 2025-01-29 | Insightec Ltd. | Monitoring tissue permeability during ultrasound procedures |
| WO2024047580A1 (en) * | 2022-08-31 | 2024-03-07 | Insightec Ltd. | Enforced tissue residency of payload molecules by acoustic disruption |
| AU2023366591A1 (en) | 2022-10-28 | 2025-04-24 | Histosonics, Inc. | Histotripsy systems and methods |
| KR102626932B1 (ko) * | 2023-01-03 | 2024-01-23 | 주식회사 뉴머스 | 환자 맞춤형 헬멧 및 이의 제조 방법 |
| WO2024221001A2 (en) | 2023-04-20 | 2024-10-24 | Histosonics, Inc. | Histotripsy systems and associated methods including user interfaces and workflows for treatment planning and therapy |
| WO2024257021A1 (en) * | 2023-06-13 | 2024-12-19 | Insightec Ltd. | Tissue type-based blood-brain barrier opening and treatment parameter establishment systems thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011529039A (ja) | 2008-07-23 | 2011-12-01 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 超音波仲介による薬送達 |
| JP2012524596A (ja) | 2009-04-23 | 2012-10-18 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | 鼻気流式デバイスコントローラ |
| US20130046229A1 (en) | 2008-03-19 | 2013-02-21 | The Trustees Of Columbia University In The City Of New York | Systems and methods for opening of a tissue barrier |
| JP2016509506A (ja) | 2013-01-29 | 2016-03-31 | インサイテック・リミテッド | シミュレーションベース集束超音波治療計画 |
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| US6369039B1 (en) | 1998-06-30 | 2002-04-09 | Scimed Life Sytems, Inc. | High efficiency local drug delivery |
| US6309355B1 (en) * | 1998-12-22 | 2001-10-30 | The Regents Of The University Of Michigan | Method and assembly for performing ultrasound surgery using cavitation |
| US7611462B2 (en) | 2003-05-22 | 2009-11-03 | Insightec-Image Guided Treatment Ltd. | Acoustic beam forming in phased arrays including large numbers of transducer elements |
| CN101005858A (zh) * | 2004-08-18 | 2007-07-25 | 伯拉考开发股份有限公司 | 用于反差成像的充气微泡组合物 |
| TWI271202B (en) * | 2004-11-12 | 2007-01-21 | Ching-Hua Wang | Formula for stimulating biological active substance entering skin or mucous membrane and the application of the same |
| CN100536783C (zh) * | 2005-01-19 | 2009-09-09 | 微星科技股份有限公司 | 颅内压量测方法及系统 |
| JP2006231304A (ja) * | 2005-02-28 | 2006-09-07 | Advance Alpha:Kk | マイクロバブル発生方法およびマイクロバブル発生装置 |
| JP4630127B2 (ja) * | 2005-05-17 | 2011-02-09 | 株式会社日立製作所 | 超音波診断治療装置 |
| EP1904179A2 (en) * | 2005-06-07 | 2008-04-02 | Koninklijke Philips Electronics N.V. | Method and apparatus for ultrasound drug delivery and thermal therapy with phase-convertible fluids |
| US20070016039A1 (en) * | 2005-06-21 | 2007-01-18 | Insightec-Image Guided Treatment Ltd. | Controlled, non-linear focused ultrasound treatment |
| JP4369907B2 (ja) * | 2005-07-01 | 2009-11-25 | 株式会社日立製作所 | 音響化学治療装置 |
| CN100386057C (zh) * | 2005-10-31 | 2008-05-07 | 西安交通大学 | 基于包膜微泡的灌注成像与超声控制释放的系统和方法 |
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| WO2010030819A1 (en) | 2008-09-10 | 2010-03-18 | The Trustees Of Columbia University In The City Of New York | Systems and methods for opening a tissue |
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| CN101698121B (zh) * | 2009-10-23 | 2011-06-22 | 西安交通大学 | 促进药物透过血脑屏障的适型超声系统 |
| CN103180014B (zh) | 2010-07-29 | 2016-12-28 | 因赛泰克有限公司 | 用于非侵入性的治疗疗法的移动补偿 |
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| CN103842020B (zh) * | 2011-10-05 | 2016-12-28 | 皇家飞利浦有限公司 | 用于超声介导的递送的化验 |
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| CA2878491A1 (en) * | 2012-07-08 | 2014-01-16 | Sunnybrook Health Sciences Centre | System and method for using ultrasound-stimulated microbubble exposures to induce ceramide accumulation in endothelial and tumor cells |
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| RU2650598C2 (ru) | 2012-10-12 | 2018-04-16 | Профаунд Медикал Инк. | Мультифокусные соникации для гипертермических лечебных воздействий с использованием ультразвука, сфокусированного под контролем магнитно-резонансной томографии |
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| CN104146730A (zh) * | 2014-08-18 | 2014-11-19 | 中国人民解放军第三军医大学第二附属医院 | 医用诊断超声波激励微泡调控双侧血脑屏障通透性的用途 |
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| US10475192B2 (en) | 2016-06-10 | 2019-11-12 | Insightec, Ltd. | Motion tracking during non-invasive therapy |
-
2018
- 2018-06-29 JP JP2019571961A patent/JP7289061B2/ja active Active
- 2018-06-29 WO PCT/IB2018/000811 patent/WO2019002940A1/en not_active Ceased
- 2018-06-29 WO PCT/IB2018/000841 patent/WO2019002947A1/en not_active Ceased
- 2018-06-29 EP EP18765703.6A patent/EP3645116B1/en active Active
- 2018-06-29 EP EP18768933.6A patent/EP3645117B1/en active Active
- 2018-06-29 WO PCT/IB2018/000834 patent/WO2019002943A1/en not_active Ceased
- 2018-06-29 EP EP18759374.4A patent/EP3645118B1/en active Active
- 2018-06-29 JP JP2019571960A patent/JP7232204B2/ja active Active
- 2018-06-29 CN CN201880043399.8A patent/CN111132732B/zh active Active
- 2018-06-29 CN CN201880043567.3A patent/CN110831665B/zh active Active
- 2018-06-29 JP JP2019571959A patent/JP2020525167A/ja active Pending
- 2018-06-29 CN CN201880056389.8A patent/CN111032157B/zh active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130046229A1 (en) | 2008-03-19 | 2013-02-21 | The Trustees Of Columbia University In The City Of New York | Systems and methods for opening of a tissue barrier |
| JP2011529039A (ja) | 2008-07-23 | 2011-12-01 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 超音波仲介による薬送達 |
| JP2012524596A (ja) | 2009-04-23 | 2012-10-18 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | 鼻気流式デバイスコントローラ |
| JP2016509506A (ja) | 2013-01-29 | 2016-03-31 | インサイテック・リミテッド | シミュレーションベース集束超音波治療計画 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111132732B (zh) | 2021-09-21 |
| EP3645118A1 (en) | 2020-05-06 |
| CN111032157B (zh) | 2023-04-21 |
| WO2019002940A1 (en) | 2019-01-03 |
| EP3645117A1 (en) | 2020-05-06 |
| JP2020525167A (ja) | 2020-08-27 |
| EP3645116A1 (en) | 2020-05-06 |
| WO2019002947A8 (en) | 2020-04-02 |
| EP3645117B1 (en) | 2021-07-28 |
| CN111132732A (zh) | 2020-05-08 |
| WO2019002943A1 (en) | 2019-01-03 |
| CN110831665B (zh) | 2022-03-04 |
| EP3645116B1 (en) | 2021-07-28 |
| JP2020525169A (ja) | 2020-08-27 |
| WO2019002947A1 (en) | 2019-01-03 |
| EP3645118B1 (en) | 2023-11-29 |
| JP2020525168A (ja) | 2020-08-27 |
| CN110831665A (zh) | 2020-02-21 |
| CN111032157A (zh) | 2020-04-17 |
| JP7232204B2 (ja) | 2023-03-02 |
| EP3645118C0 (en) | 2023-11-29 |
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