CN111132732B - 增强对靶组织的治疗同时限制对非靶组织的损伤的系统 - Google Patents

增强对靶组织的治疗同时限制对非靶组织的损伤的系统 Download PDF

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CN111132732B
CN111132732B CN201880043399.8A CN201880043399A CN111132732B CN 111132732 B CN111132732 B CN 111132732B CN 201880043399 A CN201880043399 A CN 201880043399A CN 111132732 B CN111132732 B CN 111132732B
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microbubbles
frequency
ultrasound
radius
target tissue
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CN111132732A (zh
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R·德皮乔托
约阿夫·利维
J·格林菲尔德
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Insightec Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0039—Ultrasound therapy using microbubbles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0073—Ultrasound therapy using multiple frequencies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0082—Scanning transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A61N2007/0095—Beam steering by modifying an excitation signal

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Surgical Instruments (AREA)
CN201880043399.8A 2017-06-29 2018-06-29 增强对靶组织的治疗同时限制对非靶组织的损伤的系统 Active CN111132732B (zh)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201762526550P 2017-06-29 2017-06-29
US201762526545P 2017-06-29 2017-06-29
US201762526548P 2017-06-29 2017-06-29
US15/637,163 US11123575B2 (en) 2017-06-29 2017-06-29 3D conformal radiation therapy with reduced tissue stress and improved positional tolerance
US62/526,545 2017-06-29
US62/526,550 2017-06-29
US62/526,548 2017-06-29
US15/637,163 2017-06-29
US201762597076P 2017-12-11 2017-12-11
US201762597073P 2017-12-11 2017-12-11
US62/597,076 2017-12-11
US62/597,073 2017-12-11
PCT/IB2018/000841 WO2019002947A1 (en) 2017-06-29 2018-06-29 ULTRASONIC FREQUENCY AND MICROBULLE SIZE OPTIMIZATION IN MICROBULLY ASSISTED ULTRASONIC TREATMENT

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CN111132732A CN111132732A (zh) 2020-05-08
CN111132732B true CN111132732B (zh) 2021-09-21

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CN201880043399.8A Active CN111132732B (zh) 2017-06-29 2018-06-29 增强对靶组织的治疗同时限制对非靶组织的损伤的系统
CN201880043567.3A Active CN110831665B (zh) 2017-06-29 2018-06-29 用于破坏靶组织以进行治疗以及评估靶组织破坏的系统
CN201880056389.8A Active CN111032157B (zh) 2017-06-29 2018-06-29 基于模拟的药物治疗计划

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CN201880043567.3A Active CN110831665B (zh) 2017-06-29 2018-06-29 用于破坏靶组织以进行治疗以及评估靶组织破坏的系统
CN201880056389.8A Active CN111032157B (zh) 2017-06-29 2018-06-29 基于模拟的药物治疗计划

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EP (3) EP3645116B1 (enExample)
JP (3) JP7289061B2 (enExample)
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WO (3) WO2019002940A1 (enExample)

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US20250263798A1 (en) 2021-07-01 2025-08-21 Insightec Ltd. Diagnostic and treatment monitoring based on blood-brain barrier disruption
CN113714070B (zh) * 2021-07-26 2022-05-24 中北大学 混合振膜结构宽频带电容式微机械超声换能器设计方法
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WO2024047580A1 (en) * 2022-08-31 2024-03-07 Insightec Ltd. Enforced tissue residency of payload molecules by acoustic disruption
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KR102626932B1 (ko) * 2023-01-03 2024-01-23 주식회사 뉴머스 환자 맞춤형 헬멧 및 이의 제조 방법
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EP3645118A1 (en) 2020-05-06
CN111032157B (zh) 2023-04-21
WO2019002940A1 (en) 2019-01-03
EP3645117A1 (en) 2020-05-06
JP2020525167A (ja) 2020-08-27
EP3645116A1 (en) 2020-05-06
WO2019002947A8 (en) 2020-04-02
EP3645117B1 (en) 2021-07-28
CN111132732A (zh) 2020-05-08
WO2019002943A1 (en) 2019-01-03
CN110831665B (zh) 2022-03-04
EP3645116B1 (en) 2021-07-28
JP2020525169A (ja) 2020-08-27
WO2019002947A1 (en) 2019-01-03
EP3645118B1 (en) 2023-11-29
JP2020525168A (ja) 2020-08-27
CN110831665A (zh) 2020-02-21
CN111032157A (zh) 2020-04-17
JP7232204B2 (ja) 2023-03-02
JP7289061B2 (ja) 2023-06-09
EP3645118C0 (en) 2023-11-29

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