JP7282294B2 - アルテミシニン由来のトリマーおよびテトラマーおよびそれらの使用 - Google Patents

アルテミシニン由来のトリマーおよびテトラマーおよびそれらの使用 Download PDF

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JP7282294B2
JP7282294B2 JP2020523749A JP2020523749A JP7282294B2 JP 7282294 B2 JP7282294 B2 JP 7282294B2 JP 2020523749 A JP2020523749 A JP 2020523749A JP 2020523749 A JP2020523749 A JP 2020523749A JP 7282294 B2 JP7282294 B2 JP 7282294B2
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pharmaceutically acceptable
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artesunate
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JP2021504302A5 (enrdf_load_stackoverflow
JP2021504302A (ja
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ザオ，ミン
ジョウ，リ－ミン
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2020523749A 2017-11-21 2018-11-21 アルテミシニン由来のトリマーおよびテトラマーおよびそれらの使用 Active JP7282294B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762588921P 2017-11-21 2017-11-21
US62/588,921 2017-11-21
PCT/US2018/062356 WO2019104247A1 (en) 2017-11-21 2018-11-21 Artemisinin-derived trimers and tetramers and their use thereof

Publications (3)

Publication Number Publication Date
JP2021504302A JP2021504302A (ja) 2021-02-15
JP2021504302A5 JP2021504302A5 (enrdf_load_stackoverflow) 2022-01-04
JP7282294B2 true JP7282294B2 (ja) 2023-05-29

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JP2020523749A Active JP7282294B2 (ja) 2017-11-21 2018-11-21 アルテミシニン由来のトリマーおよびテトラマーおよびそれらの使用

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Country Link
US (2) US11358970B2 (enrdf_load_stackoverflow)
EP (1) EP3713566A4 (enrdf_load_stackoverflow)
JP (1) JP7282294B2 (enrdf_load_stackoverflow)
CN (2) CN111372583B (enrdf_load_stackoverflow)
WO (1) WO2019104247A1 (enrdf_load_stackoverflow)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019104247A1 (en) * 2017-11-21 2019-05-31 Ming Zhao Artemisinin-derived trimers and tetramers and their use thereof
US12156915B2 (en) 2019-02-26 2024-12-03 Mahmoud A. Elsohly Selected artemisinin dimers for the treatment of lashmaniasis
CN113264946A (zh) * 2021-05-11 2021-08-17 中国人民解放军陆军军医大学第一附属医院 一种双氢青蒿素衍生物及其在制备治疗、预防脑血管病药物中的应用
CN115282145A (zh) * 2022-09-05 2022-11-04 中南大学湘雅二医院 青蒿琥酯在制备治疗青光眼的药物或制剂中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060074251A1 (en) 2003-01-23 2006-04-06 Man-Kil Jung Deoxoartemisinin analogs, process for their preparation, and anticancer agent comprising them

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102481282A (zh) 2009-03-24 2012-05-30 新加坡国立大学 青蒿素衍生物用于治疗哮喘和慢性阻塞性肺病(copd)的用途
DK2424880T3 (en) * 2009-04-28 2016-10-24 Res Dev Foundation Immunoreactive Ehrlichia p120 / p140 epitopes, and uses thereof
WO2010135427A2 (en) * 2009-05-19 2010-11-25 The Johns Hopkins University Trioxane monomers and dimers
US8883765B2 (en) * 2009-12-08 2014-11-11 The John Hopkins University Anti-cytomegalovirus activity of artemisinin-derived dimers
CN102153564B (zh) 2011-01-31 2013-07-24 中国科学院上海药物研究所 含氮原子的青蒿素二聚体、其制备方法及用途
EP2717879B1 (en) 2011-06-10 2017-08-16 Queen Mary University of London Artemisinin and derivatives for use in the treatment of trauma haemorrhage
CN103450468B (zh) * 2012-05-30 2016-06-15 北京凯正生物工程发展有限责任公司 青蒿琥酯聚乙二醇化衍生物、其药物组合物及其用途
WO2014090306A1 (en) 2012-12-12 2014-06-19 Queen Mary & Westfield College, University Of London Artemisinin and its derivatives for use in the treatment of kidney disease
US9314460B1 (en) * 2013-04-09 2016-04-19 Stc.Unm Method for cancer cell reprogramming
CN105078964A (zh) 2015-08-20 2015-11-25 桂林医学院附属医院 青蒿琥酯在制备治疗特发性肺纤维化药物中的应用
WO2019104247A1 (en) * 2017-11-21 2019-05-31 Ming Zhao Artemisinin-derived trimers and tetramers and their use thereof
CN109467565B (zh) 2018-08-16 2020-07-10 云白药征武科技(上海)有限公司 双氢青蒿素三聚体及其制备方法和应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060074251A1 (en) 2003-01-23 2006-04-06 Man-Kil Jung Deoxoartemisinin analogs, process for their preparation, and anticancer agent comprising them

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Antiviral Res.，2018年，152，104-110
Bioorg. Med. Chem.，2001年，10，227-232
Bioorg. Med. Chem.，2009年，17，7949-7957
Eur. J. Med. Chem.，2017年，140，595-603

Also Published As

Publication number Publication date
EP3713566A4 (en) 2021-07-14
WO2019104247A1 (en) 2019-05-31
US12134624B2 (en) 2024-11-05
US20210079011A1 (en) 2021-03-18
JP2021504302A (ja) 2021-02-15
EP3713566A1 (en) 2020-09-30
CN118546165A (zh) 2024-08-27
US20220275003A1 (en) 2022-09-01
CN111372583A (zh) 2020-07-03
US11358970B2 (en) 2022-06-14
CN111372583B (zh) 2024-06-14

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