JP7281406B2 - ポネシモドを含有する医薬的組み合わせ - Google Patents

ポネシモドを含有する医薬的組み合わせ Download PDF

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Publication number
JP7281406B2
JP7281406B2 JP2019549459A JP2019549459A JP7281406B2 JP 7281406 B2 JP7281406 B2 JP 7281406B2 JP 2019549459 A JP2019549459 A JP 2019549459A JP 2019549459 A JP2019549459 A JP 2019549459A JP 7281406 B2 JP7281406 B2 JP 7281406B2
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Prior art keywords
pharmaceutical composition
ponesimod
treatment
teriflunomide
pharmaceutical
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JP2019549459A
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Japanese (ja)
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JP2020510045A5 (https=
JP2020510045A (ja
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クローゼル マルティーヌ
プゾル レティシア
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Actelion Pharmaceuticals Ltd
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Actelion Pharmaceuticals Ltd
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Priority to JP2022204487A priority Critical patent/JP2023030091A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
JP2019549459A 2017-03-14 2018-03-13 ポネシモドを含有する医薬的組み合わせ Active JP7281406B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022204487A JP2023030091A (ja) 2017-03-14 2022-12-21 ポネシモドを含有する医薬的組み合わせ
JP2024067486A JP2024096962A (ja) 2017-03-14 2024-04-18 ポネシモドを含有する医薬的組み合わせ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2017/055994 2017-03-14
EP2017055994 2017-03-14
PCT/EP2018/056185 WO2018167030A1 (en) 2017-03-14 2018-03-13 Pharmaceutical combination comprising ponesimod

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022204487A Division JP2023030091A (ja) 2017-03-14 2022-12-21 ポネシモドを含有する医薬的組み合わせ

Publications (3)

Publication Number Publication Date
JP2020510045A JP2020510045A (ja) 2020-04-02
JP2020510045A5 JP2020510045A5 (https=) 2021-04-22
JP7281406B2 true JP7281406B2 (ja) 2023-05-25

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JP2019549459A Active JP7281406B2 (ja) 2017-03-14 2018-03-13 ポネシモドを含有する医薬的組み合わせ
JP2022204487A Pending JP2023030091A (ja) 2017-03-14 2022-12-21 ポネシモドを含有する医薬的組み合わせ
JP2024067486A Pending JP2024096962A (ja) 2017-03-14 2024-04-18 ポネシモドを含有する医薬的組み合わせ

Family Applications After (2)

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JP2022204487A Pending JP2023030091A (ja) 2017-03-14 2022-12-21 ポネシモドを含有する医薬的組み合わせ
JP2024067486A Pending JP2024096962A (ja) 2017-03-14 2024-04-18 ポネシモドを含有する医薬的組み合わせ

Country Status (24)

Country Link
US (3) US11723896B2 (https=)
EP (1) EP3595657A1 (https=)
JP (3) JP7281406B2 (https=)
KR (1) KR102574562B1 (https=)
CN (1) CN110381942B (https=)
AU (2) AU2018233109B2 (https=)
BR (1) BR112019018894A2 (https=)
CA (1) CA3056301C (https=)
CL (1) CL2019002525A1 (https=)
CO (1) CO2019008510A2 (https=)
CR (1) CR20190464A (https=)
DO (1) DOP2019000257A (https=)
EA (1) EA201992117A1 (https=)
EC (1) ECSP19073317A (https=)
IL (1) IL269239B2 (https=)
JO (1) JOP20190207A1 (https=)
MA (1) MA49822A (https=)
MX (1) MX390941B (https=)
NI (1) NI201900092A (https=)
PE (1) PE20191489A1 (https=)
PH (1) PH12019502110A1 (https=)
SG (1) SG11201907308UA (https=)
UA (1) UA125756C2 (https=)
WO (1) WO2018167030A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190207A1 (ar) * 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود
US11014940B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Thiazolidinone and oxazolidinone compounds and formulations
US11186556B1 (en) 2018-10-16 2021-11-30 Celgene Corporation Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
US11014897B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof
US11013723B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms of a thiazolidinone compound, compositions and methods of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007511563A (ja) 2003-11-21 2007-05-10 アクテリオン　ファマシューティカルズ　リミテッド 新規チアゾリジン−４−オン誘導体
JP2008517059A (ja) 2004-10-19 2008-05-22 アベンティス・ファーマスーティカルズ・インコーポレイテツド 炎症性腸疾患を治療するための（ｚ）−２−シアノ−３−ヒドロキシ−ブタ−２−エン酸−（４’−トリフルオロメチルフェニル）−アミドの使用
JP2011514379A (ja) 2008-03-17 2011-05-06 アクテリオン ファーマシューティカルズ リミテッド 選択的ｓ１ｐ１レセプターアゴニストの投与法
WO2016091996A1 (en) 2014-12-11 2016-06-16 Actelion Pharmaceuticals Ltd Dosing regimen for a selective s1p1 receptor agonist

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ES448386A1 (es) 1975-06-05 1978-04-16 Hoechst Ag Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico.
DE2854439A1 (de) 1978-12-16 1980-07-03 Hoechst Ag Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung
US5268382A (en) 1985-09-27 1993-12-07 Hoechst Aktiengesellschaft Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus
DE3534440A1 (de) 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
ES2237553T3 (es) 2000-02-15 2005-08-01 Teva Pharmaceutical Industries Ltd. Procedimiento para la sintesis de leflunomida.
EP1381356B1 (en) * 2001-04-05 2008-05-28 Aventis Pharmaceuticals Inc. Use of (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
GB0123571D0 (en) 2001-04-05 2001-11-21 Aventis Pharm Prod Inc Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
US6894184B2 (en) 2003-03-18 2005-05-17 Aventis Pharma Deutschland Gmbh Process for preparing 2-cyano-3-hydroxy-N-(phenyl)but-2-enamides
USRE43833E1 (en) 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
DE102006017896A1 (de) 2006-04-13 2007-10-25 Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg Leflunomid enthaltende pharmazeutische Zusammensetzungen
TWI460166B (zh) 2006-11-23 2014-11-11 Actelion Pharmaceuticals Ltd 製備２-亞胺基-四氫噻唑-４-酮衍生物之新穎方法
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JP2013533286A (ja) 2010-07-30 2013-08-22 セントルイス ユニバーシティ 疼痛を治療する方法
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SMT202000298T1 (it) 2012-08-17 2020-07-08 Actelion Pharmaceuticals Ltd Processo per la produzione di (2z,5z)-5-(3-cloro-4((r)-2,3-diidrossipropossi) benziliden)-2-(propilimmino)-3-(o-tolil)tiazolidin-4-one e intermedio usato in detto processo
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MA41139B1 (fr) 2014-12-11 2026-02-27 Laboratoires Juvise Pharmaceuticals Combinaison pharmaceutique comprenant du ponesimod et son utilisation dans le traitement de la sclérose en plaque
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JOP20190207A1 (ar) * 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود

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Publication number Priority date Publication date Assignee Title
JP2007511563A (ja) 2003-11-21 2007-05-10 アクテリオン　ファマシューティカルズ　リミテッド 新規チアゾリジン−４−オン誘導体
JP2008517059A (ja) 2004-10-19 2008-05-22 アベンティス・ファーマスーティカルズ・インコーポレイテツド 炎症性腸疾患を治療するための（ｚ）−２−シアノ−３−ヒドロキシ−ブタ−２−エン酸−（４’−トリフルオロメチルフェニル）−アミドの使用
JP2011514379A (ja) 2008-03-17 2011-05-06 アクテリオン ファーマシューティカルズ リミテッド 選択的ｓ１ｐ１レセプターアゴニストの投与法
WO2016091996A1 (en) 2014-12-11 2016-06-16 Actelion Pharmaceuticals Ltd Dosing regimen for a selective s1p1 receptor agonist

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Also Published As

Publication number Publication date
AU2018233109A1 (en) 2019-08-22
CA3056301A1 (en) 2018-09-20
EA201992117A1 (ru) 2020-02-17
JP2024096962A (ja) 2024-07-17
KR20190122716A (ko) 2019-10-30
MX2019010874A (es) 2019-12-11
KR102574562B1 (ko) 2023-09-04
US12527772B2 (en) 2026-01-20
US20200069655A1 (en) 2020-03-05
AU2018233109B2 (en) 2023-09-28
US20240139161A1 (en) 2024-05-02
IL269239B1 (en) 2023-03-01
SG11201907308UA (en) 2019-09-27
IL269239A (en) 2019-11-28
MA49822A (fr) 2020-06-17
US11723896B2 (en) 2023-08-15
CO2019008510A2 (es) 2019-10-21
ECSP19073317A (es) 2019-11-30
NI201900092A (es) 2020-03-11
WO2018167030A1 (en) 2018-09-20
CN110381942B (zh) 2022-12-27
CL2019002525A1 (es) 2020-02-07
PE20191489A1 (es) 2019-10-21
CR20190464A (es) 2019-11-26
US20260108501A1 (en) 2026-04-23
JOP20190207A1 (ar) 2019-09-10
PH12019502110A1 (en) 2020-03-16
JP2023030091A (ja) 2023-03-07
CN110381942A (zh) 2019-10-25
CA3056301C (en) 2024-10-01
JP2020510045A (ja) 2020-04-02
IL269239B2 (en) 2023-07-01
DOP2019000257A (es) 2020-09-15
UA125756C2 (uk) 2022-06-01
BR112019018894A2 (pt) 2020-04-14
AU2023274118A1 (en) 2023-12-21
EP3595657A1 (en) 2020-01-22
AU2023274118B2 (en) 2024-12-12
MX390941B (es) 2025-03-21

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