JP7261793B2 - Ｓｒｐｋ１阻害剤 - Google Patents

Ｓｒｐｋ１阻害剤 Download PDF

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JP7261793B2
JP7261793B2 JP2020517549A JP2020517549A JP7261793B2 JP 7261793 B2 JP7261793 B2 JP 7261793B2 JP 2020517549 A JP2020517549 A JP 2020517549A JP 2020517549 A JP2020517549 A JP 2020517549A JP 7261793 B2 JP7261793 B2 JP 7261793B2
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methyl
phenyl
compound
furan
carboxamide
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Japanese (ja)
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JP2020535172A5 (enExample
JP2020535172A (ja
Inventor
ダグラス バクスター，アンドリュー
モリス，ジョナサン
デヴィット モーリー，アンドリュー
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エクソネイト リミテッド
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Priority claimed from GBGB1715637.3A external-priority patent/GB201715637D0/en
Priority claimed from GBGB1810765.6A external-priority patent/GB201810765D0/en
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Publication of JP2020535172A5 publication Critical patent/JP2020535172A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2020517549A 2017-09-27 2018-09-26 Ｓｒｐｋ１阻害剤 Active JP7261793B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1715637.3A GB201715637D0 (en) 2017-09-27 2017-09-27 SRPK1 Inhibitors
GB1715637.3 2017-09-27
GB1810765.6 2018-06-29
GBGB1810765.6A GB201810765D0 (en) 2018-06-29 2018-06-29 SRPK1 inhibitors
PCT/GB2018/052735 WO2019063996A1 (en) 2017-09-27 2018-09-26 INHIBITORS OF SRPK1

Publications (3)

Publication Number Publication Date
JP2020535172A JP2020535172A (ja) 2020-12-03
JP2020535172A5 JP2020535172A5 (enExample) 2021-11-04
JP7261793B2 true JP7261793B2 (ja) 2023-04-20

Family

ID=63722692

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020517549A Active JP7261793B2 (ja) 2017-09-27 2018-09-26 Ｓｒｐｋ１阻害剤

Country Status (7)

Country Link
US (2) US11420969B2 (enExample)
EP (1) EP3687990A1 (enExample)
JP (1) JP7261793B2 (enExample)
CN (1) CN111448193B (enExample)
AU (1) AU2018341084B2 (enExample)
CA (1) CA3077749A1 (enExample)
WO (1) WO2019063996A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3821947A1 (en) * 2019-11-13 2021-05-19 Libra Therapeutics, Inc. Heterocyclic trpml1 agonists
US12698266B2 (en) 2019-12-19 2026-08-04 Casma Therapeutics, Inc. TRPML modulators
GB202010829D0 (en) 2020-07-14 2020-08-26 Exonate Ltd Compounds for treatment of neovascular diseases
US20240221945A1 (en) * 2023-01-03 2024-07-04 Industry-Academic Cooperation Foundation, Yonsei University Server and method for predicting incidence of moyamoya disease through learning of fundus image
CN120917015A (zh) * 2023-01-20 2025-11-07 元启(苏州)生物制药有限公司 Srpk1抑制剂和使用方法
WO2025243082A2 (en) * 2024-05-24 2025-11-27 The Chinese University Of Hong Kong Covalent protein-protein interaction inhibitor against srpks

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016504270A (ja) 2012-10-17 2016-02-12 ザ ユニバーシティ オブ ブリストル 眼血管形成（ｏｃｕｌａｒｎｅｏｖａｓｃｕｌａｎ）を治療するのに有用な化合物
WO2017064512A1 (en) 2015-10-16 2017-04-20 Exonate Limited Compounds
JP2017518360A (ja) 2014-04-17 2017-07-06 ザ ユニバーシティ オブ ノッティンガム 化合物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002317333C1 (en) 2001-08-01 2009-06-25 University Of Bristol VEGF isoform
AU2003249741A1 (en) * 2002-07-03 2004-01-23 Hartmut M. Hanauske-Abel Methods of inhibiting 4-hydroxyphenylpyruvate dioxygenase in a living system
MXPA05011503A (es) * 2003-04-25 2006-05-31 Johnson & Johnson Inhibidores de la c-fms cinasa.
DK2666481T3 (en) 2003-12-26 2019-02-25 Masatoshi Hagiwara A method for regulating the phosphorylation of SR protein and antiviral agents comprising an SR protein activity regulator as the active ingredient
WO2008076918A2 (en) * 2006-12-15 2008-06-26 University Of Maryland, Baltimore Anti-cancer agents and androgen inhibition activity compound
US20140249135A1 (en) 2007-03-01 2014-09-04 Novartis Ag Pim kinase inhibitors and methods of their use
CN101679266B (zh) 2007-03-01 2015-05-06 诺华股份有限公司 Pim激酶抑制剂及其应用方法
GB0704678D0 (en) 2007-03-09 2007-04-18 Univ Bristol Pro- and anti-angiogenic treatments
WO2009020198A1 (ja) 2007-08-03 2009-02-12 Kinopharma, Inc. 抗ｄｎａウイルス作用を有するアニリン誘導体
GB0803912D0 (en) 2008-02-29 2008-05-07 Univ Bristol Novel Uses of VEGFxxxb
EP2358382A2 (en) 2008-11-22 2011-08-24 The University of Bristol NOVEL USES OF VEGFxxxB
WO2011036429A1 (en) 2009-09-25 2011-03-31 The University Of Bristol Detection of risk of pre-eclampsia
GB201009173D0 (en) 2010-05-28 2010-07-14 Univ Bristol Treatment of pain
US9321740B2 (en) * 2011-01-26 2016-04-26 Zafgen, Inc. Tetrazole compounds and methods of making and using same
EP3256461B1 (en) * 2015-02-13 2023-09-13 Azienda Ospedaliera Universitaria Senese Urea and sulfonamide derivatives as human helicase ddx3 inhibitors useful in the treatment of viral diseases
WO2020097408A1 (en) * 2018-11-09 2020-05-14 Nimbus Artemis, Inc. Acly inhibitors and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016504270A (ja) 2012-10-17 2016-02-12 ザ ユニバーシティ オブ ブリストル 眼血管形成（ｏｃｕｌａｒｎｅｏｖａｓｃｕｌａｎ）を治療するのに有用な化合物
JP2017518360A (ja) 2014-04-17 2017-07-06 ザ ユニバーシティ オブ ノッティンガム 化合物
WO2017064512A1 (en) 2015-10-16 2017-04-20 Exonate Limited Compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BATSON J. et al.，Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease，ACS chemical biology，2017年03月17日，Vol.12, No.3，p.825-832
REGISTRY（STN）[online]，2015年05月15日，[検索日 2022.08.05]，CAS Registry Number: 1705453-84-4

Also Published As

Publication number Publication date
US20200270249A1 (en) 2020-08-27
EP3687990A1 (en) 2020-08-05
AU2018341084A1 (en) 2020-04-23
US20220389015A1 (en) 2022-12-08
US12325704B2 (en) 2025-06-10
WO2019063996A1 (en) 2019-04-04
CA3077749A1 (en) 2019-04-04
CN111448193A (zh) 2020-07-24
US11420969B2 (en) 2022-08-23
JP2020535172A (ja) 2020-12-03
CN111448193B (zh) 2023-12-22
AU2018341084B2 (en) 2023-04-13

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