JP7258748B2 - サイクリン依存性キナーゼ１２（ｃｄｋ１２）の阻害剤およびその使用 - Google Patents

サイクリン依存性キナーゼ１２（ｃｄｋ１２）の阻害剤およびその使用 Download PDF

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JP7258748B2
JP7258748B2 JP2019527379A JP2019527379A JP7258748B2 JP 7258748 B2 JP7258748 B2 JP 7258748B2 JP 2019527379 A JP2019527379 A JP 2019527379A JP 2019527379 A JP2019527379 A JP 2019527379A JP 7258748 B2 JP7258748 B2 JP 7258748B2
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グレイ，ナタナエル，エス．
チャン，ティンフー
ジアン，バイシャン
クフャトコフスキ，ニコラス，ポール
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ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019527379A 2016-11-22 2017-11-22 サイクリン依存性キナーゼ１２（ｃｄｋ１２）の阻害剤およびその使用 Active JP7258748B2 (ja)

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US201662425519P 2016-11-22 2016-11-22
US62/425,519 2016-11-22
PCT/US2017/063132 WO2018098361A1 (en) 2016-11-22 2017-11-22 Inhibitors of cyclin-dependent kinase 12 (cdk12) and uses thereof

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EP3902542A4 (en) 2018-12-28 2022-09-07 Dana-Farber Cancer Institute, Inc. CYCLIN DEPENDENT KINASE 7 INHIBITORS AND USES THEREOF
JP2022529700A (ja) * 2019-04-23 2022-06-23 ダナ－ファーバー キャンサー インスティテュート，インコーポレイテッド サイクリン依存性キナーゼ１２（ｃｄｋ１２）の分解剤およびその使用
WO2020219926A1 (en) * 2019-04-24 2020-10-29 The Trustees Of The University Of Pennsylvania Treatment of cancer with cdk inhibitors
CN114901284A (zh) * 2019-10-29 2022-08-12 希洛斯医药品股份有限公司 用细胞周期蛋白依赖性激酶7(cdk7)抑制剂治疗生物标志物鉴定的患者的癌症的方法
CN111269217B (zh) * 2020-04-07 2021-01-08 苏州信诺维医药科技有限公司 一种嘧啶胺类化合物、其制备方法及应用
CN111393415B (zh) * 2020-04-30 2020-11-20 苏州信诺维医药科技有限公司 一种杂芳腈类化合物及其应用
CN114133394B (zh) * 2020-08-12 2023-12-08 赛诺哈勃药业（成都）有限公司 一种选择性针对细胞周期依赖性激酶12活性的化合物、制备方法及医药用途
US20230303512A1 (en) * 2020-08-26 2023-09-28 Massachusetts Institute Of Technology Modulators of myb-mediated transcription and uses thereof
IL310368A (en) 2021-08-18 2024-03-01 Chemocentryx Inc Arylsulfonyl(hydroxy)piperidines as CCR6 inhibitors
MX2024002173A (es) 2021-08-18 2024-03-26 Chemocentryx Inc Compuestos de arilsulfonilo como inhibidores de ccr6.
WO2023091726A1 (en) * 2021-11-18 2023-05-25 Syros Pharmaceuticals, Inc. Inhibitors of cyclin‑dependent kinase 12 (cdk12)
TW202329937A (zh) 2021-12-03 2023-08-01 美商英塞特公司 雙環胺ｃｋ１２抑制劑
US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors
CN114452391B (zh) * 2022-01-28 2023-08-25 深圳市泰尔康生物医药科技有限公司 Cdk16作为靶标在制备用于治疗三阴性乳腺癌的药物中的应用
WO2024186319A1 (en) 2023-03-09 2024-09-12 Minneamrita Therapeutics Llc Drug combination for treatment of gastric cancer
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JP2010536869A (ja) 2007-08-20 2010-12-02 ワイス・エルエルシー ナフチルピリミジン、ナフチルピラジンおよびナフチルピリダジン類似体、ならびにＷｎｔ−βカテニン細胞メッセージ伝達系のアゴニストとしてのその使用
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JP2012511021A (ja) 2008-12-05 2012-05-17 アークル インコーポレイテッド Ｒａｆの阻害剤およびその使用
JP2016512534A (ja) 2013-03-13 2016-04-28 ヤンセン ファーマシューティカ エヌ．ベー． 置換ピペリジン化合物及びこれらのオレキシン受容体調節因子としての使用
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EP3544971B1 (en) 2022-07-06
EP3544971A1 (en) 2019-10-02
US20200361906A1 (en) 2020-11-19
US11932625B2 (en) 2024-03-19
AU2017363307A1 (en) 2019-05-02
US20230227433A9 (en) 2023-07-20
AU2017363307B2 (en) 2021-07-29
CA3041563A1 (en) 2018-05-31
US11306070B2 (en) 2022-04-19
US20210317105A9 (en) 2021-10-14
WO2018098361A1 (en) 2018-05-31
JP2019535749A (ja) 2019-12-12
CA3041563C (en) 2023-10-31
US20220213067A1 (en) 2022-07-07

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