JP7254719B2 - 薬物送達用のポリマーペースト組成物 - Google Patents

薬物送達用のポリマーペースト組成物 Download PDF

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JP7254719B2
JP7254719B2 JP2019566745A JP2019566745A JP7254719B2 JP 7254719 B2 JP7254719 B2 JP 7254719B2 JP 2019566745 A JP2019566745 A JP 2019566745A JP 2019566745 A JP2019566745 A JP 2019566745A JP 7254719 B2 JP7254719 B2 JP 7254719B2
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paste
plga
molecular weight
daltons
drug
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JP2020523303A5 (enExample
JP2020523303A (ja
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ケー. ジャクソン,ジョン
イー. グリーブ,マーチン
シュミット,ヴェロニカ
ケッシュ,クラウディア
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ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08Lactones or lactides
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66Polyesters containing oxygen in the form of ether groups
    • C08G63/664Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019566745A 2017-06-13 2018-06-13 薬物送達用のポリマーペースト組成物 Active JP7254719B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762518800P 2017-06-13 2017-06-13
US62/518,800 2017-06-13
PCT/CA2018/050714 WO2018227293A1 (en) 2017-06-13 2018-06-13 Polymeric paste compositions for drug delivery

Publications (3)

Publication Number Publication Date
JP2020523303A JP2020523303A (ja) 2020-08-06
JP2020523303A5 JP2020523303A5 (enExample) 2021-07-26
JP7254719B2 true JP7254719B2 (ja) 2023-04-10

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JP2019566745A Active JP7254719B2 (ja) 2017-06-13 2018-06-13 薬物送達用のポリマーペースト組成物

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US (2) US11167034B2 (enExample)
EP (1) EP3638311A4 (enExample)
JP (1) JP7254719B2 (enExample)
CN (1) CN110740752B (enExample)
AU (1) AU2018285975B2 (enExample)
BR (1) BR112019026225A2 (enExample)
CA (1) CA3067269C (enExample)
WO (1) WO2018227293A1 (enExample)

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GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
AU2016355236C1 (en) 2015-11-16 2022-09-22 Medincell A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
EP3638311A4 (en) * 2017-06-13 2020-12-16 The University of British Columbia COMPOSITIONS OF POLYMERIC PASTE FOR DRUG ADMINISTRATION
CN111432807A (zh) 2017-10-06 2020-07-17 铸造疗法股份有限公司 用于控制释放治疗剂的可植入贮库
WO2019136490A1 (en) 2018-01-08 2019-07-11 Foundry Therapeutics, Inc. Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents
EP3793536A1 (en) 2018-05-12 2021-03-24 Foundry Therapeutics, Inc. Implantable polymer depots for the controlled release of therapeutic agents
EP3843710A1 (en) 2018-08-28 2021-07-07 Foundry Therapeutics, Inc. Polymer implants
AU2020273190B2 (en) * 2019-04-11 2025-11-27 Foundry Therapeutics, Inc. Implantable depots for localized, sustained, controlled release of therapeutic agents to treat cancer and related symptoms and conditions
EP4100471A4 (en) 2020-02-07 2024-03-13 The University of British Columbia MUCOADHESIVE POLYMER DRUG DELIVERY COMPOSITIONS AND METHODS
WO2024168423A1 (en) * 2023-02-14 2024-08-22 1376683 B.C. Ltd Topical copolymer formulations for hydrophobic drug delivery
WO2025058571A1 (en) * 2023-09-15 2025-03-20 Agency For Science, Technology And Research Polymer composition comprising a thermogelling polymer and a tyrosine kinase inhibitor, and related methods thereof

Citations (6)

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JP2003517886A (ja) 1999-12-22 2003-06-03 サムヤン コーポレイション ドラッグデリバリーシステム用生分解性ブロック共重合体の液体組成物およびその製造方法
JP2005535638A (ja) 2002-06-28 2005-11-24 マクロメド・インコーポレーテッド 薬剤送達のための生物分解性ブロックコポリマー組成物
JP2007524628A (ja) 2003-06-26 2007-08-30 シヴィダ・インコーポレイテッド In−Situゲル化薬物輸送システム
JP2008501455A (ja) 2004-06-09 2008-01-24 シル テクノロジー ゲーエムベーハー インサイチュー硬化ペースト、その製造および使用
JP2011530568A (ja) 2008-08-12 2011-12-22 ノバルティス アーゲー 医薬組成物
JP2012529922A (ja) 2009-06-15 2012-11-29 アボット カーディオヴァスキュラー システムズ インコーポレイテッド ポリ(エチレングリコール)及びポリ(ラクチド−グリコリド)のブロックコポリマーを含む埋込型医療機器及びそのためのコーティング物

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JP2003517886A (ja) 1999-12-22 2003-06-03 サムヤン コーポレイション ドラッグデリバリーシステム用生分解性ブロック共重合体の液体組成物およびその製造方法
JP2005535638A (ja) 2002-06-28 2005-11-24 マクロメド・インコーポレーテッド 薬剤送達のための生物分解性ブロックコポリマー組成物
JP2007524628A (ja) 2003-06-26 2007-08-30 シヴィダ・インコーポレイテッド In−Situゲル化薬物輸送システム
JP2008501455A (ja) 2004-06-09 2008-01-24 シル テクノロジー ゲーエムベーハー インサイチュー硬化ペースト、その製造および使用
JP2011530568A (ja) 2008-08-12 2011-12-22 ノバルティス アーゲー 医薬組成物
JP2012529922A (ja) 2009-06-15 2012-11-29 アボット カーディオヴァスキュラー システムズ インコーポレイテッド ポリ(エチレングリコール)及びポリ(ラクチド−グリコリド)のブロックコポリマーを含む埋込型医療機器及びそのためのコーティング物

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Also Published As

Publication number Publication date
CA3067269A1 (en) 2018-12-20
BR112019026225A2 (pt) 2020-06-30
US20200147223A1 (en) 2020-05-14
AU2018285975B2 (en) 2023-11-16
CA3067269C (en) 2024-01-09
WO2018227293A1 (en) 2018-12-20
US20220152207A1 (en) 2022-05-19
EP3638311A1 (en) 2020-04-22
CN110740752B (zh) 2023-11-17
US11167034B2 (en) 2021-11-09
JP2020523303A (ja) 2020-08-06
CN110740752A (zh) 2020-01-31
EP3638311A4 (en) 2020-12-16
AU2018285975A1 (en) 2020-01-02

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