CN110740752B - 用于药物递送的聚合物糊剂组合物 - Google Patents

用于药物递送的聚合物糊剂组合物 Download PDF

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Publication number
CN110740752B
CN110740752B CN201880039808.7A CN201880039808A CN110740752B CN 110740752 B CN110740752 B CN 110740752B CN 201880039808 A CN201880039808 A CN 201880039808A CN 110740752 B CN110740752 B CN 110740752B
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composition
paste
plga
molecular weight
peg
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Chinese (zh)
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CN110740752A (zh
Inventor
约翰·K·杰克逊
马丁·E·格里夫
维罗尼卡·施密特
克劳迪娅·凯什
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University of British Columbia
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University of British Columbia
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880039808.7A 2017-06-13 2018-06-13 用于药物递送的聚合物糊剂组合物 Active CN110740752B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762518800P 2017-06-13 2017-06-13
US62/518,800 2017-06-13
PCT/CA2018/050714 WO2018227293A1 (en) 2017-06-13 2018-06-13 Polymeric paste compositions for drug delivery

Publications (2)

Publication Number Publication Date
CN110740752A CN110740752A (zh) 2020-01-31
CN110740752B true CN110740752B (zh) 2023-11-17

Family

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CN201880039808.7A Active CN110740752B (zh) 2017-06-13 2018-06-13 用于药物递送的聚合物糊剂组合物

Country Status (8)

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US (2) US11167034B2 (enExample)
EP (1) EP3638311A4 (enExample)
JP (1) JP7254719B2 (enExample)
CN (1) CN110740752B (enExample)
AU (1) AU2018285975B2 (enExample)
BR (1) BR112019026225A2 (enExample)
CA (1) CA3067269C (enExample)
WO (1) WO2018227293A1 (enExample)

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AU2016355236C1 (en) 2015-11-16 2022-09-22 Medincell A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
EP3638311A4 (en) * 2017-06-13 2020-12-16 The University of British Columbia COMPOSITIONS OF POLYMERIC PASTE FOR DRUG ADMINISTRATION
CN111432807A (zh) 2017-10-06 2020-07-17 铸造疗法股份有限公司 用于控制释放治疗剂的可植入贮库
WO2019136490A1 (en) 2018-01-08 2019-07-11 Foundry Therapeutics, Inc. Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents
EP3793536A1 (en) 2018-05-12 2021-03-24 Foundry Therapeutics, Inc. Implantable polymer depots for the controlled release of therapeutic agents
EP3843710A1 (en) 2018-08-28 2021-07-07 Foundry Therapeutics, Inc. Polymer implants
AU2020273190B2 (en) * 2019-04-11 2025-11-27 Foundry Therapeutics, Inc. Implantable depots for localized, sustained, controlled release of therapeutic agents to treat cancer and related symptoms and conditions
EP4100471A4 (en) 2020-02-07 2024-03-13 The University of British Columbia MUCOADHESIVE POLYMER DRUG DELIVERY COMPOSITIONS AND METHODS
WO2024168423A1 (en) * 2023-02-14 2024-08-22 1376683 B.C. Ltd Topical copolymer formulations for hydrophobic drug delivery
WO2025058571A1 (en) * 2023-09-15 2025-03-20 Agency For Science, Technology And Research Polymer composition comprising a thermogelling polymer and a tyrosine kinase inhibitor, and related methods thereof

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WO2005120595A2 (en) * 2004-06-09 2005-12-22 Scil Technology Gmbh In situ hardening paste, its manufacture and use

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US6187640B1 (en) 1998-11-17 2001-02-13 Fujitsu Limited Semiconductor device manufacturing method including various oxidation steps with different concentration of chlorine to form a field oxide
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Also Published As

Publication number Publication date
CA3067269A1 (en) 2018-12-20
BR112019026225A2 (pt) 2020-06-30
US20200147223A1 (en) 2020-05-14
AU2018285975B2 (en) 2023-11-16
CA3067269C (en) 2024-01-09
WO2018227293A1 (en) 2018-12-20
US20220152207A1 (en) 2022-05-19
JP7254719B2 (ja) 2023-04-10
EP3638311A1 (en) 2020-04-22
US11167034B2 (en) 2021-11-09
JP2020523303A (ja) 2020-08-06
CN110740752A (zh) 2020-01-31
EP3638311A4 (en) 2020-12-16
AU2018285975A1 (en) 2020-01-02

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