JP7250808B2 - 抗がん剤としての環状ジヌクレオチド - Google Patents
抗がん剤としての環状ジヌクレオチド Download PDFInfo
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- JP7250808B2 JP7250808B2 JP2020546409A JP2020546409A JP7250808B2 JP 7250808 B2 JP7250808 B2 JP 7250808B2 JP 2020546409 A JP2020546409 A JP 2020546409A JP 2020546409 A JP2020546409 A JP 2020546409A JP 7250808 B2 JP7250808 B2 JP 7250808B2
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US201862640325P | 2018-03-08 | 2018-03-08 | |
| US62/640,325 | 2018-03-08 | ||
| PCT/US2019/021145 WO2019173587A1 (fr) | 2018-03-08 | 2019-03-07 | Dinucléotides cycliques en tant qu'agents anticancéreux |
Publications (3)
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| JP2021515016A JP2021515016A (ja) | 2021-06-17 |
| JPWO2019173587A5 JPWO2019173587A5 (fr) | 2022-02-17 |
| JP7250808B2 true JP7250808B2 (ja) | 2023-04-03 |
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| JP2020546409A Active JP7250808B2 (ja) | 2018-03-08 | 2019-03-07 | 抗がん剤としての環状ジヌクレオチド |
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| US (1) | US11945834B2 (fr) |
| EP (1) | EP3762397B1 (fr) |
| JP (1) | JP7250808B2 (fr) |
| KR (1) | KR20200130362A (fr) |
| CN (1) | CN111801341B (fr) |
| ES (1) | ES2980374T3 (fr) |
| WO (1) | WO2019173587A1 (fr) |
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| WO2019074887A1 (fr) | 2017-10-10 | 2019-04-18 | Bristol-Myers Squibb Company | Dinucléotides cycliques utilisés en tant qu'agents anticancéreux |
| TW202200136A (zh) | 2020-04-10 | 2022-01-01 | 日商小野藥品工業股份有限公司 | 癌治療方法 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017027646A1 (fr) | 2015-08-13 | 2017-02-16 | Merck Sharp & Dohme Corp. | Composés de di-nucléotide cyclique en tant qu'agonistes sting (stimulateur de gène interféron) |
| WO2017123669A1 (fr) | 2016-01-11 | 2017-07-20 | Gary Glick | Dinucléotides cycliques pour traiter des affections associées à l'activité sting comme le cancer |
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| EP3762397A1 (fr) | 2021-01-13 |
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| ES2980374T3 (es) | 2024-10-01 |
| CN111801341A (zh) | 2020-10-20 |
| US20210002323A1 (en) | 2021-01-07 |
| US11945834B2 (en) | 2024-04-02 |
| KR20200130362A (ko) | 2020-11-18 |
| EP3762397B1 (fr) | 2024-05-01 |
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