JP7249955B2 - ヒトIL-27のαサブユニットの分泌可能なムテイン - Google Patents

ヒトIL-27のαサブユニットの分泌可能なムテイン Download PDF

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JP7249955B2
JP7249955B2 JP2019560107A JP2019560107A JP7249955B2 JP 7249955 B2 JP7249955 B2 JP 7249955B2 JP 2019560107 A JP2019560107 A JP 2019560107A JP 2019560107 A JP2019560107 A JP 2019560107A JP 7249955 B2 JP7249955 B2 JP 7249955B2
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seq
mutein
human interleukin
subunit
amino acid
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JP2020518249A5 (enExample
JP2020518249A (ja
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マティアス フィージ
ステファニー ミューラー
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テクニッシェ ウニヴェルズィテート ミュンヘン
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/50Fusion polypeptide containing protease site

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019560107A 2017-05-04 2018-05-04 ヒトIL-27のαサブユニットの分泌可能なムテイン Active JP7249955B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17169358 2017-05-04
EP17169358.3 2017-05-04
PCT/EP2018/061561 WO2018202876A1 (en) 2017-05-04 2018-05-04 Secretion-competent muteins of the human il-27 alpha-subunit

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JP2020518249A JP2020518249A (ja) 2020-06-25
JP2020518249A5 JP2020518249A5 (enExample) 2021-06-17
JP7249955B2 true JP7249955B2 (ja) 2023-03-31

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US (1) US11358998B2 (enExample)
EP (1) EP3619228A1 (enExample)
JP (1) JP7249955B2 (enExample)
CN (1) CN110709413B (enExample)
AU (1) AU2018262811B2 (enExample)
CA (1) CA3060219A1 (enExample)
WO (1) WO2018202876A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3955955B1 (en) 2019-04-19 2025-02-26 Synerkine Pharma B.V. A fusion protein comprising il13
JP2023501515A (ja) * 2019-11-12 2023-01-18 テクニッシェ ウニヴェルズィテート ミュンヘン ヒトIL-27αサブユニットの均質ムテイン
WO2024213695A1 (en) * 2023-04-14 2024-10-17 Technische Universitaet Muenchen Method for producing the subunits of human interleukin 35 from interleukin 12 and interleukin 27
CN116832146B (zh) * 2023-06-30 2024-02-13 广东暨安特博生物科技有限公司 Il-27蛋白在制备治疗阿尔茨海默症的产品的应用
WO2025140436A1 (zh) * 2023-12-27 2025-07-03 上海药明生物技术有限公司 重组il-27蛋白及其制备方法

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Publication number Priority date Publication date Assignee Title
JP4839434B2 (ja) * 2005-03-14 2011-12-21 千葉県 p28分子またはその遺伝子を含む医薬製剤
HK1206764A1 (en) * 2012-03-26 2016-01-15 Axcella Health Inc. Nutritive proteins and methods

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Database NCBI Reference Sequence [online], NP_663611, 2015-02-15uploaded, [retrieved on 2022-04-20], < https://www.ncbi.nlm.nih.gov/protein/21704110?sat=46&satkey=70707665>, interleukin-27 subunit alpha precursor[Mus musculus]
Database NCBI Reference Sequence [online], NP_663634, 2016-10-15uploaded, [retrieved on 2022-04-20], <https://www.ncbi.nlm.nih.gov/protein/28416913?sat=46&satkey=69182784>,Definition: interleukin-27 subunit alpha precursor [Homo sapiens]
Database NCBI Reference Sequence [online], XP_003281965, 2015-05-13uploaded, [retrieved on 2022-04-19], < https://www.ncbi.nlm.nih.gov/protein/332265926?sat=47&satkey=95882820>, Definition: PREDICTED: interleukin-27subunit alpha [Nomascus leucogenys]

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CN110709413A (zh) 2020-01-17
US20200062817A1 (en) 2020-02-27
WO2018202876A1 (en) 2018-11-08
AU2018262811B2 (en) 2021-10-21
US11358998B2 (en) 2022-06-14
CN110709413B (zh) 2023-11-28
EP3619228A1 (en) 2020-03-11
JP2020518249A (ja) 2020-06-25
AU2018262811A1 (en) 2019-12-19
CA3060219A1 (en) 2018-11-08

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