CN110709413B - 人白细胞介素27α-亚基的能够分泌的突变蛋白 - Google Patents
人白细胞介素27α-亚基的能够分泌的突变蛋白 Download PDFInfo
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
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- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP17169358 | 2017-05-04 | ||
| EP17169358.3 | 2017-05-04 | ||
| PCT/EP2018/061561 WO2018202876A1 (en) | 2017-05-04 | 2018-05-04 | Secretion-competent muteins of the human il-27 alpha-subunit |
Publications (2)
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|---|---|
| CN110709413A CN110709413A (zh) | 2020-01-17 |
| CN110709413B true CN110709413B (zh) | 2023-11-28 |
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| CA (1) | CA3060219A1 (enExample) |
| WO (1) | WO2018202876A1 (enExample) |
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| EP3955955B1 (en) | 2019-04-19 | 2025-02-26 | Synerkine Pharma B.V. | A fusion protein comprising il13 |
| JP2023501515A (ja) * | 2019-11-12 | 2023-01-18 | テクニッシェ ウニヴェルズィテート ミュンヘン | ヒトＩＬ－２７αサブユニットの均質ムテイン |
| WO2024213695A1 (en) * | 2023-04-14 | 2024-10-17 | Technische Universitaet Muenchen | Method for producing the subunits of human interleukin 35 from interleukin 12 and interleukin 27 |
| CN116832146B (zh) * | 2023-06-30 | 2024-02-13 | 广东暨安特博生物科技有限公司 | Il-27蛋白在制备治疗阿尔茨海默症的产品的应用 |
| WO2025140436A1 (zh) * | 2023-12-27 | 2025-07-03 | 上海药明生物技术有限公司 | 重组il-27蛋白及其制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1973898A (zh) * | 2005-03-14 | 2007-06-06 | 复旦大学 | 一种含p28分子或其基因的医药制剂 |
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| HK1206764A1 (en) * | 2012-03-26 | 2016-01-15 | Axcella Health Inc. | Nutritive proteins and methods |
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2018
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- 2018-05-04 US US16/609,726 patent/US11358998B2/en active Active
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1973898A (zh) * | 2005-03-14 | 2007-06-06 | 复旦大学 | 一种含p28分子或其基因的医药制剂 |
Non-Patent Citations (3)
| Title |
|---|
| A role for IL-27p28 as an antagonist of gp130-mediated signaling;Jason S. Stumhofer 等;《Nature Immunology》;20101107;第11卷(第12期);摘要，第1120页左栏最后1段-右栏第1段，第1125页左栏第4段，图1 * |
| IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells;Stefan Pflanz 等;《Immunity》;20020630;第16卷(第6期);摘要，第780页右栏第1段-第781页右栏第1段，第786页左栏第2段-右栏第1段，图1-2 * |
| The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses;Osamu Shimozato 等;《Immunology》;20091231;第128卷;摘要，第e818页右栏最后1段-第e819页左栏第1段，第e823页左栏第1段，图1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110709413A (zh) | 2020-01-17 |
| US20200062817A1 (en) | 2020-02-27 |
| WO2018202876A1 (en) | 2018-11-08 |
| AU2018262811B2 (en) | 2021-10-21 |
| US11358998B2 (en) | 2022-06-14 |
| EP3619228A1 (en) | 2020-03-11 |
| JP2020518249A (ja) | 2020-06-25 |
| AU2018262811A1 (en) | 2019-12-19 |
| CA3060219A1 (en) | 2018-11-08 |
| JP7249955B2 (ja) | 2023-03-31 |
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