JP7239575B2 - サンプル中の自律的に活性なb細胞受容体または自律的に活性化されたb細胞受容体を認識する方法 - Google Patents

サンプル中の自律的に活性なb細胞受容体または自律的に活性化されたb細胞受容体を認識する方法 Download PDF

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JP7239575B2
JP7239575B2 JP2020522785A JP2020522785A JP7239575B2 JP 7239575 B2 JP7239575 B2 JP 7239575B2 JP 2020522785 A JP2020522785 A JP 2020522785A JP 2020522785 A JP2020522785 A JP 2020522785A JP 7239575 B2 JP7239575 B2 JP 7239575B2
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JP2020527727A (ja
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ビアスナー ウルリヒ
ユマー ハッサン
クラップロート ホルガー
アー. ケセマイアー マーク
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AVA Lifescience GmbH
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39566Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061Blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
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  • Biomedical Technology (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2020522785A 2017-07-07 2018-07-05 サンプル中の自律的に活性なb細胞受容体または自律的に活性化されたb細胞受容体を認識する方法 Active JP7239575B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP17001167 2017-07-07
EP17001166.2 2017-07-07
EP17001166 2017-07-07
EP17001167.0 2017-07-07
EP18162666.4A EP3424527A1 (de) 2017-07-07 2018-03-19 Diagnostisches verfahren
EP18162666.4 2018-03-19
PCT/EP2018/068316 WO2019008128A1 (de) 2017-07-07 2018-07-05 Diagnostisches verfahren

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JP2020527727A JP2020527727A (ja) 2020-09-10
JP2020527727A5 JP2020527727A5 (enExample) 2021-08-12
JP7239575B2 true JP7239575B2 (ja) 2023-03-14

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JP2020522786A Active JP7271532B2 (ja) 2017-07-07 2018-07-05 生物学的結合分子
JP2020522785A Active JP7239575B2 (ja) 2017-07-07 2018-07-05 サンプル中の自律的に活性なb細胞受容体または自律的に活性化されたb細胞受容体を認識する方法

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US (2) US11591391B2 (enExample)
EP (4) EP3424528A1 (enExample)
JP (2) JP7271532B2 (enExample)
CA (1) CA3070848A1 (enExample)
WO (2) WO2019008129A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3424528A1 (de) * 2017-07-07 2019-01-09 AVA Lifescience GmbH Biologische bindemoleküle
US20220356244A1 (en) * 2019-05-02 2022-11-10 Ava Lifescience Gmbh Method for selecting biological binding molecules
CA3148214A1 (en) * 2019-05-02 2020-11-05 Ava Lifescience Gmbh Antigent binding domains and uses therefor
EP3733709A1 (de) * 2019-05-02 2020-11-04 AVA Lifescience Biologische bindemoleküle
IL310901A (en) * 2021-08-18 2024-04-01 Univ Pennsylvania Compositions and methods for chimeric antigen receptors specific to b cell receptors
JP2025508389A (ja) 2022-02-10 2025-03-26 サインエイバイオソリューションズ ゲーエムベーハー 慢性リンパ性白血病のb細胞受容体を標的とする抗体及びその使用
EP4227321A1 (en) * 2022-02-10 2023-08-16 AVA Lifescience GmbH Antibodies targeting the b-cell receptor of chronic lymphocytic leukemia (cll) for use in treatment of cll
CA3262006A1 (en) * 2022-07-25 2024-02-01 Sinabiosolution Gmbh Humanized chimeric antigen receptors targeting the B-lymphocyte receptor in chronic lymphocytic leukemia and their uses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020526590A (ja) 2017-07-07 2020-08-31 アー・ファウ・アー ライフサイエンス ゲー・エム・ベー・ハーAVA Lifescience GmbH 生物学的結合分子

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Publication number Priority date Publication date Assignee Title
US7393531B2 (en) * 2003-01-21 2008-07-01 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of MCSP
JP6401060B2 (ja) 2012-02-24 2018-10-03 アッヴィ・ステムセントルクス・エル・エル・シー 抗sez6抗体及び使用方法
WO2014179714A1 (en) * 2013-05-03 2014-11-06 The Board Of Regents Of The University Of Texas System Generating peptoid vaccines
BR112016004242A8 (pt) * 2013-08-28 2018-06-12 Stemcentrx Inc Métodos para conjugação sítio-específica de anticorpos e composições

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020526590A (ja) 2017-07-07 2020-08-31 アー・ファウ・アー ライフサイエンス ゲー・エム・ベー・ハーAVA Lifescience GmbH 生物学的結合分子

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BOJARCZUK, K. et al.,B-cell receptor signaling in the pathogenesis of lymphoid malignancies,Blood Cells, Molecules and Diseases,2015年,Vol.55,pp.255-265
MINDEN, M. D. et al.,Chronic lymphocyic leukaemia is driven by antigen-independent cell-autonomous signalling,Nature,2012年09月13日,Vol.489,pp.309-312
MINICI, C. et al.,Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia,nature communications,2017年06月09日,Vol.8, Article number: 15746,pp.1-12

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Publication number Publication date
US20200199225A1 (en) 2020-06-25
US11591391B2 (en) 2023-02-28
CA3070847A1 (en) 2019-01-10
CA3070848A1 (en) 2019-01-10
WO2019008129A1 (de) 2019-01-10
JP2020527727A (ja) 2020-09-10
EP3424528A1 (de) 2019-01-09
EP3615072A1 (de) 2020-03-04
JP2020526590A (ja) 2020-08-31
EP3615073A1 (de) 2020-03-04
US11634487B2 (en) 2023-04-25
US20200209246A1 (en) 2020-07-02
EP3424527A1 (de) 2019-01-09
JP7271532B2 (ja) 2023-05-11
WO2019008128A1 (de) 2019-01-10

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