JP7219220B2 - 改善された血清アルブミン結合剤 - Google Patents

改善された血清アルブミン結合剤 Download PDF

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JP7219220B2
JP7219220B2 JP2019538382A JP2019538382A JP7219220B2 JP 7219220 B2 JP7219220 B2 JP 7219220B2 JP 2019538382 A JP2019538382 A JP 2019538382A JP 2019538382 A JP2019538382 A JP 2019538382A JP 7219220 B2 JP7219220 B2 JP 7219220B2
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compound
variable domain
serum albumin
single variable
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JP2020515518A5 (https=
JP2020515518A (ja
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スターレンス，ステファニー
シュテッフェンゼン，ソレン
モリゾ，エリカ
セルドベル，アン
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アブリンクス エン．ヴェー．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019538382A 2017-01-17 2018-01-17 改善された血清アルブミン結合剤 Active JP7219220B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022196232A JP7628996B2 (ja) 2017-01-17 2022-12-08 改善された血清アルブミン結合剤
JP2024204085A JP2025026992A (ja) 2017-01-17 2024-11-22 改善された血清アルブミン結合剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762446988P 2017-01-17 2017-01-17
US62/446,988 2017-01-17
PCT/EP2018/051083 WO2018134235A1 (en) 2017-01-17 2018-01-17 Improved serum albumin binders

Related Child Applications (1)

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JP2022196232A Division JP7628996B2 (ja) 2017-01-17 2022-12-08 改善された血清アルブミン結合剤

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JP2020515518A JP2020515518A (ja) 2020-05-28
JP2020515518A5 JP2020515518A5 (https=) 2021-01-07
JP7219220B2 true JP7219220B2 (ja) 2023-02-07

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JP2019538382A Active JP7219220B2 (ja) 2017-01-17 2018-01-17 改善された血清アルブミン結合剤
JP2022196232A Active JP7628996B2 (ja) 2017-01-17 2022-12-08 改善された血清アルブミン結合剤
JP2024204085A Pending JP2025026992A (ja) 2017-01-17 2024-11-22 改善された血清アルブミン結合剤

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JP2024204085A Pending JP2025026992A (ja) 2017-01-17 2024-11-22 改善された血清アルブミン結合剤

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US (2) US11414481B2 (https=)
EP (3) EP3571225B1 (https=)
JP (3) JP7219220B2 (https=)
KR (2) KR102662499B1 (https=)
CN (2) CN117285623A (https=)
AU (2) AU2018209151B2 (https=)
BR (1) BR112019014599A2 (https=)
CA (1) CA3050575A1 (https=)
DK (1) DK3571225T3 (https=)
ES (1) ES2991459T3 (https=)
FI (1) FI3571225T3 (https=)
HR (1) HRP20241469T1 (https=)
HU (1) HUE068790T2 (https=)
IL (2) IL312292A (https=)
LT (1) LT3571225T (https=)
MX (2) MX2019008496A (https=)
PT (1) PT3571225T (https=)
RS (1) RS66117B1 (https=)
SG (2) SG11201906264YA (https=)
SI (1) SI3571225T1 (https=)
WO (1) WO2018134235A1 (https=)

Cited By (1)

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JP2023025232A (ja) * 2017-01-17 2023-02-21 アブリンクス エン．ヴェー． 改善された血清アルブミン結合剤

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