JP7219213B2 - （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム - Google Patents

（ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム Download PDF

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JP7219213B2
JP7219213B2 JP2019512895A JP2019512895A JP7219213B2 JP 7219213 B2 JP7219213 B2 JP 7219213B2 JP 2019512895 A JP2019512895 A JP 2019512895A JP 2019512895 A JP2019512895 A JP 2019512895A JP 7219213 B2 JP7219213 B2 JP 7219213B2
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JP2019535643A (ja
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ジェニファー リー ネルソン
フィオン ハーレー
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ジャズ ファーマスティカルズ アイルランド リミテッド
エスケー バイオファーマスティカルズ カンパニー リミテッド
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Application filed by ジャズ ファーマスティカルズ アイルランド リミテッド, エスケー バイオファーマスティカルズ カンパニー リミテッド filed Critical ジャズ ファーマスティカルズ アイルランド リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/08—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2019512895A 2016-09-06 2017-09-06 （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム Active JP7219213B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021155292A JP7642506B2 (ja) 2016-09-06 2021-09-24 （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム
JP2024161956A JP2024178291A (ja) 2016-09-06 2024-09-19 （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662383822P 2016-09-06 2016-09-06
PCT/US2017/050233 WO2018048871A1 (en) 2016-09-06 2017-09-06 Solvate form of (r)-2-amino-3-phenylpropyl carbamate

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JP2021155292A Division JP7642506B2 (ja) 2016-09-06 2021-09-24 （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム

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JP2019535643A JP2019535643A (ja) 2019-12-12
JP2019535643A5 JP2019535643A5 (https=) 2020-09-24
JP7219213B2 true JP7219213B2 (ja) 2023-02-07

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JP2019512895A Active JP7219213B2 (ja) 2016-09-06 2017-09-06 （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム
JP2021155292A Active JP7642506B2 (ja) 2016-09-06 2021-09-24 （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム
JP2024161956A Pending JP2024178291A (ja) 2016-09-06 2024-09-19 （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム

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JP2021155292A Active JP7642506B2 (ja) 2016-09-06 2021-09-24 （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム
JP2024161956A Pending JP2024178291A (ja) 2016-09-06 2024-09-19 （ｒ）－２－アミノ－３－フェニルプロピルカルバメートの溶媒和物フォーム

Country Status (13)

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US (4) US10829443B2 (https=)
EP (2) EP3509582B1 (https=)
JP (3) JP7219213B2 (https=)
KR (1) KR102513800B1 (https=)
CN (4) CN109996540A (https=)
CA (1) CA3036071A1 (https=)
DK (1) DK3509582T3 (https=)
ES (1) ES2970887T3 (https=)
FI (1) FI3509582T3 (https=)
MY (1) MY197630A (https=)
PH (1) PH12019500493A1 (https=)
SG (1) SG11201901998WA (https=)
WO (1) WO2018048871A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12186296B1 (en) 2016-07-22 2025-01-07 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12478604B1 (en) 2016-07-22 2025-11-25 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
MY197630A (en) 2016-09-06 2023-06-29 Sk Biopharmaceuticals Co Ltd Solvate form of (r)-2-amino-3-phenylpropyl carbamate
WO2020035769A1 (en) 2018-08-14 2020-02-20 Glenmark Pharmaceuticals Limited; Glenmark Life Sciences Limited Process for the preparation of solriamfetol and salt thereof
CN113473980A (zh) 2019-03-01 2021-10-01 弗拉梅尔爱尔兰有限公司 在进食状态下具有改善的药代动力学的γ-羟基丁酸酯组合物
WO2021001457A1 (en) 2019-07-04 2021-01-07 Sandoz Ag Crystalline (r)-2-amino-3-phenylpropylcarbamate acid addition salts
IT202000013855A1 (it) 2020-06-10 2021-12-10 Flamma Spa Un processo per la purificazione del (r)-2-ammino-3-fenilpropil carbammato
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
AU2023375326A1 (en) * 2022-11-07 2025-05-22 Axsome Therapeutics Compositions and methods for treating insomnia
WO2024145545A2 (en) * 2022-12-30 2024-07-04 Axsome Malta Ltd. Methods of administering solriamfetol to lactating women
WO2024194718A1 (en) 2023-03-22 2024-09-26 Unichem Laboratories Limited A stable pharmaceutical composition and process for preparing thereof
CN121816178A (zh) 2023-05-30 2026-04-07 艾克萨姆治疗股份有限公司 用于治疗患有与阻塞性睡眠呼吸暂停和白天过度嗜睡相关的认知受损的受试者的认知受损的索安非托
KR20260033050A (ko) 2023-06-29 2026-03-10 액섬 테라퓨틱스, 인크. 수유 여성에게 솔리암페톨을 투여하는 방법
WO2025042959A1 (en) 2023-08-21 2025-02-27 Axsome Therapeutics, Inc. Use of solriamfetol for the treatment of orphan diseases
WO2025165760A1 (en) * 2024-01-29 2025-08-07 Axsome Therapeutics, Inc. Phenylalkylamino carbamates for use in the treatment of attention deficit/hyperactivity disorder

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007508293A (ja) 2003-10-08 2007-04-05 エスケー コーポレイション 活性アミン基の存在下におけるｏ−カルバモイル化合物の製造方法
JP2008546778A (ja) 2005-06-22 2008-12-25 エスケー ホルディングス カンパニー リミテッド 性機能障害を治療する方法
JP2016532679A (ja) 2013-07-18 2016-10-20 ジャズ ファーマスティカルズ インターナショナル スリー リミテッドＪａｚｚ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｉｉ Ｌｉｍｉｔｅｄ 肥満の治療
JP2017512211A (ja) 2014-02-28 2017-05-18 エスケー バイオファーマスティカルズ カンパニー リミテッド アミノカルボニルカルバメート化合物
JP2019512009A (ja) 2016-02-16 2019-05-09 ザ・ユニバーシティ・オブ・クイーンズランド スルホニルウレアおよび関連化合物ならびにこれらの利用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100197892B1 (ko) * 1994-09-09 1999-06-15 남창우 신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법
US5756817C1 (en) 1995-02-11 2001-04-17 Sk Corp O-carbamoyl-phenylananinol compounds their pharmaceutically useful salts and process for preparing the same
KR0173862B1 (ko) 1995-02-11 1999-04-01 조규향 O-카바모일-(d)-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법
KR0173863B1 (ko) 1995-04-10 1999-04-01 조규향 페닐에 치환체가 있는 o-카바모일-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법
DK1140061T3 (da) 1998-12-23 2003-08-25 Orphan Medical Inc Mikrobiologisk sunde og stabile opløsninger af gamma-hydroxybutyratsalt til behandling af narcolepsi
RU2202607C2 (ru) 2000-03-03 2003-04-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Штамм бактерий methylophilus methylotrophus - продуцент l-фенилаланина (варианты), способ получения l-фенилаланина
RU2007119648A (ru) 2004-10-28 2008-12-10 СК Холдингз Ко. Способ лечения депрессии
EP1890684B1 (en) * 2005-06-08 2013-08-14 SK Biopharmaceuticals Co., Ltd. Treatment of sleep-wake disorders
KR20120098578A (ko) 2009-06-22 2012-09-05 에스케이바이오팜 주식회사 피로의 치료 또는 예방 방법
US8232315B2 (en) 2009-06-26 2012-07-31 Sk Biopharmaceuticals Co., Ltd. Methods for treating drug addiction and improving addiction-related behavior
EP2496227B1 (en) 2009-11-06 2019-05-22 SK Biopharmaceuticals Co., Ltd. Methods for treating fibromyalgia syndrome
BR112012010670A2 (pt) 2009-11-06 2016-04-12 Sk Biopharmaceuticals Co Ltd métodos para tratamento de distúrbio de défict de atenção/hiperatividade
US8623913B2 (en) 2010-06-30 2014-01-07 Sk Biopharmaceuticals Co., Ltd. Methods for treating restless legs syndrome
US9610274B2 (en) 2010-06-30 2017-04-04 Sk Biopharmaceuticals Co., Ltd. Methods for treating bipolar disorder
US9050302B2 (en) 2013-03-01 2015-06-09 Jazz Pharmaceuticals Ireland Limited Method of administration of gamma hydroxybutyrate with monocarboxylate transporters
CA2905457A1 (en) 2013-03-13 2014-10-09 Aerial Biopharma, Llc Treatment of cataplexy
JP2016530240A (ja) 2013-07-12 2016-09-29 ジャズ ファーマスティカルズ インターナショナル スリー リミテッドＪａｚｚ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｉｉ Ｌｉｍｉｔｅｄ 禁煙の促進
MY197630A (en) * 2016-09-06 2023-06-29 Sk Biopharmaceuticals Co Ltd Solvate form of (r)-2-amino-3-phenylpropyl carbamate
KR101950254B1 (ko) 2016-09-21 2019-02-20 유상신 차량탑승자의 부재를 감지하는 지능형 카시트
WO2020035769A1 (en) * 2018-08-14 2020-02-20 Glenmark Pharmaceuticals Limited; Glenmark Life Sciences Limited Process for the preparation of solriamfetol and salt thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007508293A (ja) 2003-10-08 2007-04-05 エスケー コーポレイション 活性アミン基の存在下におけるｏ−カルバモイル化合物の製造方法
JP2008546778A (ja) 2005-06-22 2008-12-25 エスケー ホルディングス カンパニー リミテッド 性機能障害を治療する方法
JP2016532679A (ja) 2013-07-18 2016-10-20 ジャズ ファーマスティカルズ インターナショナル スリー リミテッドＪａｚｚ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｉｉ Ｌｉｍｉｔｅｄ 肥満の治療
JP2017512211A (ja) 2014-02-28 2017-05-18 エスケー バイオファーマスティカルズ カンパニー リミテッド アミノカルボニルカルバメート化合物
JP2019512009A (ja) 2016-02-16 2019-05-09 ザ・ユニバーシティ・オブ・クイーンズランド スルホニルウレアおよび関連化合物ならびにこれらの利用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
芹沢一英，医薬品の多形現象と晶析の化学，2002年09月20日，273-278

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CN120574152A (zh) 2025-09-02
SG11201901998WA (en) 2019-04-29
EP3509582A1 (en) 2019-07-17
JP7642506B2 (ja) 2025-03-10
CA3036071A1 (en) 2018-03-15
US20250340509A1 (en) 2025-11-06
EP3509582A4 (en) 2020-05-13
MY197630A (en) 2023-06-29
US12384743B2 (en) 2025-08-12
EP4364794A2 (en) 2024-05-08
US20230183172A1 (en) 2023-06-15
US10829443B2 (en) 2020-11-10
DK3509582T3 (en) 2024-02-12
WO2018048871A1 (en) 2018-03-15
FI3509582T3 (fi) 2024-02-08
KR20190065311A (ko) 2019-06-11
US20210053912A1 (en) 2021-02-25
JP2022003062A (ja) 2022-01-11
JP2024178291A (ja) 2024-12-24
CN121202730A (zh) 2025-12-26
US20190194126A1 (en) 2019-06-27
CN109996540A (zh) 2019-07-09
EP4364794A3 (en) 2024-07-24
CN121202731A (zh) 2025-12-26
JP2019535643A (ja) 2019-12-12
EP3509582B1 (en) 2023-12-20
PH12019500493A1 (en) 2019-05-27
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