JP7217631B2 - 関節リウマチの治療のための臨床応答バイオマーカーとしての抗ｐａｄ４自己抗体 - Google Patents

関節リウマチの治療のための臨床応答バイオマーカーとしての抗ｐａｄ４自己抗体 Download PDF

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JP7217631B2
JP7217631B2 JP2018562123A JP2018562123A JP7217631B2 JP 7217631 B2 JP7217631 B2 JP 7217631B2 JP 2018562123 A JP2018562123 A JP 2018562123A JP 2018562123 A JP2018562123 A JP 2018562123A JP 7217631 B2 JP7217631 B2 JP 7217631B2
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pad4
patient
antibody
antigen
binding fragment
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JP2019523759A5 (cg-RX-API-DMAC10.html
JP2019523759A (ja
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レイチェル パトリシア モアテ
アレックス ゴッドウッド
イーサン ポール グラント
マーティン マイケル カリ シュウィッカート
カーロス チャベス
メイナ リャン
トーマス ミカエル マスティリン
ジョンビン ヤオ
カウスタブ ラネード
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MedImmune Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Rehabilitation Therapy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018562123A 2016-05-24 2017-05-23 関節リウマチの治療のための臨床応答バイオマーカーとしての抗ｐａｄ４自己抗体 Active JP7217631B2 (ja)

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JP2023008716A JP2023058524A (ja) 2016-05-24 2023-01-24 関節リウマチの治療のための臨床応答バイオマーカーとしての抗ｐａｄ４自己抗体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662340560P 2016-05-24 2016-05-24
US62/340,560 2016-05-24
PCT/EP2017/062479 WO2017202879A1 (en) 2016-05-24 2017-05-23 Anti-pad4 autoantibodies as clinical response biomarkers for the treatment of rheumatoid arthritis

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JP2023008716A Division JP2023058524A (ja) 2016-05-24 2023-01-24 関節リウマチの治療のための臨床応答バイオマーカーとしての抗ｐａｄ４自己抗体

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JP2019523759A JP2019523759A (ja) 2019-08-29
JP2019523759A5 JP2019523759A5 (cg-RX-API-DMAC10.html) 2020-07-02
JP7217631B2 true JP7217631B2 (ja) 2023-02-03

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JP2023008716A Ceased JP2023058524A (ja) 2016-05-24 2023-01-24 関節リウマチの治療のための臨床応答バイオマーカーとしての抗ｐａｄ４自己抗体

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US (2) US11613580B2 (cg-RX-API-DMAC10.html)
EP (1) EP3464358A1 (cg-RX-API-DMAC10.html)
JP (2) JP7217631B2 (cg-RX-API-DMAC10.html)
AU (1) AU2017270027B2 (cg-RX-API-DMAC10.html)
CA (1) CA3024910A1 (cg-RX-API-DMAC10.html)
MA (1) MA45112A (cg-RX-API-DMAC10.html)
WO (1) WO2017202879A1 (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023058524A (ja) * 2016-05-24 2023-04-25 メディミューン リミテッド 関節リウマチの治療のための臨床応答バイオマーカーとしての抗ｐａｄ４自己抗体

Families Citing this family (4)

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JP7668220B2 (ja) * 2019-02-15 2025-04-24 イノバ ディアグノスティクス，インコーポレイテッド 関節リウマチの診断及び評価のための、組成物並びに方法
WO2021188409A1 (en) 2020-03-15 2021-09-23 Kiniksa Pharmaceuticals, Ltd. Treatment of cytokine release syndrome with gm-csf antagonists
CN111458522B (zh) * 2020-04-20 2024-01-09 杭州英邈生物科技有限公司 一种用于检测血浆白细胞介素6天然抗体的检测试剂、试剂盒及其应用
CN111733151B (zh) * 2020-07-13 2021-11-12 山东新创生物科技有限公司 一种基于padi4作为肿瘤标志物制得的抗原、抗体及应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009156615A (ja) 2007-12-25 2009-07-16 Tokyo Metropolitan Foundation For Social Welfare & Public Health Ｐａｄ４及び抗ｐａｄ４抗体の測定方法並びに関節リウマチの検出方法
US20130101611A1 (en) 2009-11-25 2013-04-25 The Johns Hopkins University Citrullination of human peptidylarginine deiminase 4 (pad-4) regulates its function and immunogenicity
US20140127720A1 (en) 2012-11-05 2014-05-08 The Johns Hopkins University Human autoantibodies specific for pad3 which are cross-reactive with pad4 and their use in the diagnosis and treatment of rheumatoid arthritis and related diseases
WO2015177097A1 (en) 2014-05-19 2015-11-26 Medimmune Limited Treatment for rheumatoid arthritis

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US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
US6818406B2 (en) 2001-03-23 2004-11-16 Mayo Foundation For Medical Education And Research Rheumatoid arthritis markers
EP1628562A2 (en) 2003-05-08 2006-03-01 Vanderbilt University A gene equation to diagnose rheumatoid arthritis
KR101481844B1 (ko) 2006-03-27 2015-01-13 메디뮨 리미티드 Ｇｍ-ｃｓｆ 수용체에 대한 결합 성분
US9267946B2 (en) * 2009-03-30 2016-02-23 Inserm (Institut National De La Sante Et De La Rec Biomarkers, methods and kits for the diagnosis of rheumatoid arthritis
CN103906767A (zh) 2011-10-10 2014-07-02 米迪缪尼有限公司 对类风湿关节炎的治疗
WO2017202879A1 (en) * 2016-05-24 2017-11-30 Medimmune Limited Anti-pad4 autoantibodies as clinical response biomarkers for the treatment of rheumatoid arthritis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009156615A (ja) 2007-12-25 2009-07-16 Tokyo Metropolitan Foundation For Social Welfare & Public Health Ｐａｄ４及び抗ｐａｄ４抗体の測定方法並びに関節リウマチの検出方法
US20130101611A1 (en) 2009-11-25 2013-04-25 The Johns Hopkins University Citrullination of human peptidylarginine deiminase 4 (pad-4) regulates its function and immunogenicity
US20140127720A1 (en) 2012-11-05 2014-05-08 The Johns Hopkins University Human autoantibodies specific for pad3 which are cross-reactive with pad4 and their use in the diagnosis and treatment of rheumatoid arthritis and related diseases
WO2015177097A1 (en) 2014-05-19 2015-11-26 Medimmune Limited Treatment for rheumatoid arthritis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ann. Rheum. Dis. (2013) vol.72, issue 9, p.1445-1452

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023058524A (ja) * 2016-05-24 2023-04-25 メディミューン リミテッド 関節リウマチの治療のための臨床応答バイオマーカーとしての抗ｐａｄ４自己抗体

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AU2017270027A1 (en) 2018-12-06
EP3464358A1 (en) 2019-04-10
US20230303707A1 (en) 2023-09-28
US20200317793A1 (en) 2020-10-08
MA45112A (fr) 2019-04-10
WO2017202879A1 (en) 2017-11-30
JP2019523759A (ja) 2019-08-29
JP2023058524A (ja) 2023-04-25
CA3024910A1 (en) 2017-11-30
AU2017270027B2 (en) 2024-07-11
US11613580B2 (en) 2023-03-28

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