JP7213188B2 - Stingアゴニストとしての環状ジヌクレオチド - Google Patents

Stingアゴニストとしての環状ジヌクレオチド Download PDF

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JP7213188B2
JP7213188B2 JP2019540532A JP2019540532A JP7213188B2 JP 7213188 B2 JP7213188 B2 JP 7213188B2 JP 2019540532 A JP2019540532 A JP 2019540532A JP 2019540532 A JP2019540532 A JP 2019540532A JP 7213188 B2 JP7213188 B2 JP 7213188B2
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compound
pharmaceutically acceptable
cancer
compounds
formula
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JP2020514316A (ja
JP2020514316A5 (enExample
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エマニュエル,スチュアート
リヒター,マーク
ジェイ. コノリー,ピーター
パトリック エドワーズ,ジェームス
ワン,グアンイ
クマール タティコンダ,サンソッシュ
ベイゲルマン,レオニド
ゾン,ミンホン
ビグナン,ギルス
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ヤンセン バイオテツク,インコーポレーテツド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
JP2019540532A 2017-01-27 2018-01-26 Stingアゴニストとしての環状ジヌクレオチド Active JP7213188B2 (ja)

Priority Applications (1)

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JP2022129286A JP2022163188A (ja) 2017-01-27 2022-08-15 Stingアゴニストとしての環状ジヌクレオチド

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762451285P 2017-01-27 2017-01-27
US62/451,285 2017-01-27
US201762454131P 2017-02-03 2017-02-03
US62/454,131 2017-02-03
PCT/IB2018/050497 WO2018138684A1 (en) 2017-01-27 2018-01-26 Cyclic dinucleotides as sting agonists

Related Child Applications (1)

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JP2022129286A Division JP2022163188A (ja) 2017-01-27 2022-08-15 Stingアゴニストとしての環状ジヌクレオチド

Publications (3)

Publication Number Publication Date
JP2020514316A JP2020514316A (ja) 2020-05-21
JP2020514316A5 JP2020514316A5 (enExample) 2021-03-04
JP7213188B2 true JP7213188B2 (ja) 2023-01-26

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JP2019540532A Active JP7213188B2 (ja) 2017-01-27 2018-01-26 Stingアゴニストとしての環状ジヌクレオチド
JP2022129286A Pending JP2022163188A (ja) 2017-01-27 2022-08-15 Stingアゴニストとしての環状ジヌクレオチド

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US (1) US11021511B2 (enExample)
EP (1) EP3573717B1 (enExample)
JP (2) JP7213188B2 (enExample)
CN (1) CN110234404A (enExample)
AU (1) AU2018212787B2 (enExample)
ES (1) ES2891326T3 (enExample)
WO (1) WO2018138684A1 (enExample)

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CA3073919A1 (en) 2017-08-30 2019-03-07 Beijing Xuanyi Pharmasciences Co., Ltd. Cyclic di-nucleotides as stimulator of interferon genes modulators
MX2020004858A (es) 2017-11-10 2020-10-01 Takeda Pharmaceuticals Co Compuestos moduladores de sting y metodos de elaboracion y uso.
US11161864B2 (en) 2018-10-29 2021-11-02 Venenum Biodesign, LLC Sting agonists
US11110106B2 (en) 2018-10-29 2021-09-07 Venenum Biodesign, LLC Sting agonists for treating bladder cancer and solid tumors
CN119735540A (zh) * 2018-11-19 2025-04-01 诺华制药股份有限公司 用于治疗与sting活性有关的疾病的化合物和组合物
WO2020227159A2 (en) 2019-05-03 2020-11-12 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity
JP7621974B2 (ja) * 2019-05-09 2025-01-27 アリゴス セラピューティクス インコーポレイテッド Stingモジュレータとしての修飾環状ジヌクレオシド化合物
EP3993834A1 (en) 2019-07-05 2022-05-11 Tambo, Inc. Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
JPWO2021206158A1 (enExample) 2020-04-10 2021-10-14
WO2021252904A1 (en) * 2020-06-11 2021-12-16 Massachusetts Institute Of Technology Ribonucleoprotein approach to boost the sting signaling for cancer immunotherapy
US20230256109A1 (en) 2020-08-07 2023-08-17 Tambo, Inc. Trans-Cyclooctene Bioorthogonal Agents and Uses in Cancer and Immunotherapy
TW202233251A (zh) 2020-11-09 2022-09-01 日商武田藥品工業股份有限公司 抗體藥物綴合物
CN120757600B (zh) * 2025-09-10 2025-11-11 天津法尔玛制药有限公司 环二核苷酸2′,3′-cG4′-MeAMP、制备方法及其在制备先天免疫激活剂中的应用

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JP2018522914A (ja) 2015-08-13 2018-08-16 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. Stingアゴニストとしての環状ジヌクレオチド化合物
JP2020500862A (ja) 2016-11-25 2020-01-16 ヤンセン バイオテツク,インコーポレーテツド Stingアゴニストとしての環状ジヌクレオチド
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WO2016100261A2 (en) 2014-12-17 2016-06-23 Lipogen Llc Method of treating cancer with cgamp or cgasmp
JP2018522914A (ja) 2015-08-13 2018-08-16 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. Stingアゴニストとしての環状ジヌクレオチド化合物
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JP2020503303A (ja) 2016-12-20 2020-01-30 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. がんの処置のための環状ジヌクレオチドstingアゴニスト
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Publication number Publication date
JP2022163188A (ja) 2022-10-25
AU2018212787A1 (en) 2019-07-25
EP3573717A1 (en) 2019-12-04
US11021511B2 (en) 2021-06-01
WO2018138684A1 (en) 2018-08-02
CN110234404A (zh) 2019-09-13
AU2018212787B2 (en) 2023-10-26
ES2891326T3 (es) 2022-01-27
EP3573717B1 (en) 2021-07-28
JP2020514316A (ja) 2020-05-21
US20190375781A1 (en) 2019-12-12

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