CN110234404A - 作为sting激动剂的环状二核苷酸 - Google Patents

作为sting激动剂的环状二核苷酸 Download PDF

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Publication number
CN110234404A
CN110234404A CN201880009027.3A CN201880009027A CN110234404A CN 110234404 A CN110234404 A CN 110234404A CN 201880009027 A CN201880009027 A CN 201880009027A CN 110234404 A CN110234404 A CN 110234404A
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CN
China
Prior art keywords
compound
formula
pharmaceutically acceptable
group
cancer
Prior art date
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Pending
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CN201880009027.3A
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English (en)
Chinese (zh)
Inventor
S.伊曼纽尔
M.里克特
P.J.康诺利
J.P.爱德华兹
王广义
S.K.塔提孔达
L.贝高曼
钟明宏
G.比尼昂
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Janssen Biotech Inc
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Janssen Biotech Inc
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Publication of CN110234404A publication Critical patent/CN110234404A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201880009027.3A 2017-01-27 2018-01-26 作为sting激动剂的环状二核苷酸 Pending CN110234404A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762451285P 2017-01-27 2017-01-27
US62/451285 2017-01-27
US201762454131P 2017-02-03 2017-02-03
US62/454131 2017-02-03
PCT/IB2018/050497 WO2018138684A1 (en) 2017-01-27 2018-01-26 Cyclic dinucleotides as sting agonists

Publications (1)

Publication Number Publication Date
CN110234404A true CN110234404A (zh) 2019-09-13

Family

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Family Applications (1)

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CN201880009027.3A Pending CN110234404A (zh) 2017-01-27 2018-01-26 作为sting激动剂的环状二核苷酸

Country Status (7)

Country Link
US (1) US11021511B2 (enExample)
EP (1) EP3573717B1 (enExample)
JP (2) JP7213188B2 (enExample)
CN (1) CN110234404A (enExample)
AU (1) AU2018212787B2 (enExample)
ES (1) ES2891326T3 (enExample)
WO (1) WO2018138684A1 (enExample)

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CN120757600A (zh) * 2025-09-10 2025-10-10 天津法尔玛制药有限公司 环二核苷酸2′,3′-cG4′-MeAMP、制备方法及其在制备先天免疫激活剂中的应用

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PH12020550585A1 (en) 2017-11-10 2021-04-19 Takeda Pharmaceuticals Co Sting modulator compounds, and methods of making and using
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EP3883651A1 (en) * 2018-11-19 2021-09-29 IFM Due, Inc. Compounds and compositions for treating conditions associated with sting activity
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CN114127082A (zh) * 2019-05-09 2022-03-01 阿里戈斯治疗公司 作为sting调节剂的经修饰的环状二核苷化合物
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US20230210968A1 (en) * 2020-06-11 2023-07-06 Massachusetts Institute Of Technology Ribonucleoprotein approach to boost the sting signaling for cancer immunotherapy
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JP7397996B2 (ja) 2020-11-09 2023-12-13 武田薬品工業株式会社 抗体薬物コンジュゲート
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CN110291096A (zh) * 2016-11-25 2019-09-27 詹森生物科技公司 环状二核苷酸作为sting激动剂

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Publication number Priority date Publication date Assignee Title
CN120757600A (zh) * 2025-09-10 2025-10-10 天津法尔玛制药有限公司 环二核苷酸2′,3′-cG4′-MeAMP、制备方法及其在制备先天免疫激活剂中的应用
CN120757600B (zh) * 2025-09-10 2025-11-11 天津法尔玛制药有限公司 环二核苷酸2′,3′-cG4′-MeAMP、制备方法及其在制备先天免疫激活剂中的应用

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Publication number Publication date
AU2018212787A1 (en) 2019-07-25
AU2018212787B2 (en) 2023-10-26
US11021511B2 (en) 2021-06-01
WO2018138684A1 (en) 2018-08-02
JP2022163188A (ja) 2022-10-25
US20190375781A1 (en) 2019-12-12
EP3573717B1 (en) 2021-07-28
JP2020514316A (ja) 2020-05-21
ES2891326T3 (es) 2022-01-27
EP3573717A1 (en) 2019-12-04
JP7213188B2 (ja) 2023-01-26

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