JP7204235B2 - 活性型α－シヌクレインに結合する抗体 - Google Patents

活性型α－シヌクレインに結合する抗体 Download PDF

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JP7204235B2
JP7204235B2 JP2020528498A JP2020528498A JP7204235B2 JP 7204235 B2 JP7204235 B2 JP 7204235B2 JP 2020528498 A JP2020528498 A JP 2020528498A JP 2020528498 A JP2020528498 A JP 2020528498A JP 7204235 B2 JP7204235 B2 JP 7204235B2
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synuclein
antibody
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JP2020529473A (ja
JP2020529473A5 (https=
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アリエル・ラウリエル
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Stressmarq Biosciences Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7047—Fibrils-Filaments-Plaque formation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
JP2020528498A 2017-08-02 2018-08-02 活性型α－シヌクレインに結合する抗体 Active JP7204235B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762540435P 2017-08-02 2017-08-02
US62/540,435 2017-08-02
PCT/CA2018/050952 WO2019023809A1 (en) 2017-08-02 2018-08-02 ANTIBODIES BINDING TO ACTIVE ALPHA-SYNUCLEINE

Publications (3)

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JP2020529473A JP2020529473A (ja) 2020-10-08
JP2020529473A5 JP2020529473A5 (https=) 2021-08-12
JP7204235B2 true JP7204235B2 (ja) 2023-01-16

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JP2020528498A Active JP7204235B2 (ja) 2017-08-02 2018-08-02 活性型α－シヌクレインに結合する抗体

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US (2) US11098108B2 (https=)
EP (1) EP3661961A4 (https=)
JP (1) JP7204235B2 (https=)
KR (1) KR102826089B1 (https=)
CN (1) CN111225923B (https=)
AU (1) AU2018312441B2 (https=)
BR (1) BR112020001970A2 (https=)
IL (1) IL272361B2 (https=)
SA (1) SA520411188B1 (https=)
WO (1) WO2019023809A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
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US10364286B2 (en) * 2016-12-22 2019-07-30 H. Lundbeck A/S Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation
BR112019013953A2 (pt) 2017-01-06 2020-02-11 Abl Bio Inc. Anticorpo anti-a-syn e uso do mesmo
CA3051839A1 (en) 2017-02-17 2018-08-23 Bristol-Myers Squibb Company Antibodies to alpha-synuclein and uses thereof
EP3618870A4 (en) 2017-05-01 2021-04-21 The Trustees of The University of Pennsylvania MONOCLONAL ANTIBODIES AGAINST ALPHA-SYNUCLEIN FIBRILLES
EP3661961A4 (en) 2017-08-02 2021-04-14 Stressmarq Biosciences Inc. ANTIBODIES BINDING TO ACTIVE ALPHA-SYNUCLEIN
EP3725806A4 (en) 2017-12-14 2022-03-30 ABL Bio Inc. BISPECIFIC ANTIBODIES AGAINST A-SYN/IGF1R AND ASSOCIATED USE
EP4268842A3 (en) * 2019-06-14 2024-05-22 ABL Bio, Inc. BISPECIFIC ANTIBODY AGAINST a-SYN/IGF1R AND USE THEREOF
US20230025707A1 (en) * 2019-11-19 2023-01-26 The Trustees Of The University Of Pennsylvania Anti-Alpha-Synuclein Monoclonal Antibodies, and Methods Using Same
NL2025332B1 (en) 2020-04-10 2021-10-26 Syngle Therapeutics B V Novel alpha-synuclein binding antibodies, or antigen binding portions thereof.
KR102505164B1 (ko) * 2020-09-29 2023-02-28 서울대학교산학협력단 신경퇴행성 질환의 예방 또는 치료용 펩타이드 및 이를 포함하는 약학 조성물
CN113912713B (zh) * 2021-12-15 2022-03-08 北京凯祥弘康生物科技有限公司 一种抗α-突触核蛋白的单克隆抗体及其应用

Citations (5)

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Publication number Priority date Publication date Assignee Title
JP2011518874A (ja) 2008-04-29 2011-06-30 バイオアーティック ニューロサイエンス アーベー α−シヌクレイン関連疾患についての治療および診断方法における使用のための抗体およびワクチン
JP2014500886A (ja) 2010-11-30 2014-01-16 ジェネンテック， インコーポレイテッド 低親和性血液脳関門受容体抗体及びその使用
JP2014523881A (ja) 2011-06-22 2014-09-18 ザ ジェネラル ホスピタル コーポレイション プロテイノパチーの処置方法
JP2014528695A (ja) 2011-06-23 2014-10-30 バイオジェン アイデック インターナショナル ニューロサイエンス ゲーエムベーハー 抗アルファシヌクレイン結合分子
JP2017514456A (ja) 2014-03-06 2017-06-08 ナショナル リサーチ カウンシル オブ カナダ インスリン様成長因子１受容体特異的抗体及びそれらの使用

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CN102317316B (zh) 2008-12-19 2014-08-13 帕尼玛制药股份公司 人抗α突触核蛋白自身抗体
JP5894939B2 (ja) * 2010-02-26 2016-03-30 バイオアークティック ニューロサイエンス アーベー プロトフィブリル結合抗体ならびにパーキンソン病、レビー小体型認知症および他のα−シヌクレイノパチーの治療および診断方法におけるこれらの使用
DK2807188T3 (da) * 2012-01-27 2019-10-07 Prothena Biosciences Ltd Humaniserede antistoffer, der genkender alpha-synuclein
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JP2011518874A (ja) 2008-04-29 2011-06-30 バイオアーティック ニューロサイエンス アーベー α−シヌクレイン関連疾患についての治療および診断方法における使用のための抗体およびワクチン
JP2014500886A (ja) 2010-11-30 2014-01-16 ジェネンテック， インコーポレイテッド 低親和性血液脳関門受容体抗体及びその使用
JP2014523881A (ja) 2011-06-22 2014-09-18 ザ ジェネラル ホスピタル コーポレイション プロテイノパチーの処置方法
JP2014528695A (ja) 2011-06-23 2014-10-30 バイオジェン アイデック インターナショナル ニューロサイエンス ゲーエムベーハー 抗アルファシヌクレイン結合分子
JP2017514456A (ja) 2014-03-06 2017-06-08 ナショナル リサーチ カウンシル オブ カナダ インスリン様成長因子１受容体特異的抗体及びそれらの使用

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Publication number Publication date
CN111225923A (zh) 2020-06-02
EP3661961A1 (en) 2020-06-10
AU2018312441A1 (en) 2020-02-06
IL272361A (en) 2020-03-31
KR20200033880A (ko) 2020-03-30
JP2020529473A (ja) 2020-10-08
US20210139569A1 (en) 2021-05-13
US11919947B2 (en) 2024-03-05
BR112020001970A2 (pt) 2020-08-04
IL272361B1 (en) 2025-02-01
WO2019023809A1 (en) 2019-02-07
EP3661961A4 (en) 2021-04-14
KR102826089B1 (ko) 2025-06-30
CN111225923B (zh) 2024-09-24
US11098108B2 (en) 2021-08-24
IL272361B2 (en) 2025-06-01
SA520411188B1 (ar) 2023-01-08
US20210355202A1 (en) 2021-11-18
AU2018312441B2 (en) 2024-10-17
CA3071634A1 (en) 2019-02-07

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