JP7202664B2 - 分析物検出用の微少流体装置 - Google Patents
分析物検出用の微少流体装置 Download PDFInfo
- Publication number
- JP7202664B2 JP7202664B2 JP2019554648A JP2019554648A JP7202664B2 JP 7202664 B2 JP7202664 B2 JP 7202664B2 JP 2019554648 A JP2019554648 A JP 2019554648A JP 2019554648 A JP2019554648 A JP 2019554648A JP 7202664 B2 JP7202664 B2 JP 7202664B2
- Authority
- JP
- Japan
- Prior art keywords
- chamber
- analyte
- fluid
- microfluidic device
- capture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
- G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
- G01N27/07—Construction of measuring vessels; Electrodes therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56961—Plant cells or fungi
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0621—Control of the sequence of chambers filled or emptied
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0668—Trapping microscopic beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0803—Disc shape
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/088—Passive control of flow resistance by specific surface properties
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/37—Assays involving biological materials from specific organisms or of a specific nature from fungi
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Fluid Mechanics (AREA)
- Electrochemistry (AREA)
- Botany (AREA)
- Mycology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1705328.1A GB2561173A (en) | 2017-04-03 | 2017-04-03 | Microfluidic device for detection of analytes |
| GB1705328.1 | 2017-04-03 | ||
| PCT/EP2018/057997 WO2018184957A1 (en) | 2017-04-03 | 2018-03-28 | Microfluidic device for detection of analytes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020515864A JP2020515864A (ja) | 2020-05-28 |
| JP2020515864A5 JP2020515864A5 (https=) | 2021-05-06 |
| JP7202664B2 true JP7202664B2 (ja) | 2023-01-12 |
Family
ID=58682739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019554648A Active JP7202664B2 (ja) | 2017-04-03 | 2018-03-28 | 分析物検出用の微少流体装置 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11406976B2 (https=) |
| EP (1) | EP3606667B1 (https=) |
| JP (1) | JP7202664B2 (https=) |
| AU (2) | AU2018247760B2 (https=) |
| CA (1) | CA3058081C (https=) |
| ES (1) | ES2992414T3 (https=) |
| GB (1) | GB2561173A (https=) |
| PL (1) | PL3606667T3 (https=) |
| WO (1) | WO2018184957A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019126388A1 (en) * | 2017-12-19 | 2019-06-27 | Biological Dynamics, Inc. | Methods and devices for detection of multiple analytes from a biological sample |
| WO2020223900A1 (en) * | 2019-05-07 | 2020-11-12 | Boe Technology Group Co., Ltd. | Method of classifying and counting cells in a sample, bioassay kit, and micropore array plate |
| WO2025083614A1 (en) * | 2023-10-19 | 2025-04-24 | Vital Biosciences Inc. | Devices, systems, and methods for optical analysis of biological samples |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005530127A (ja) | 2001-11-27 | 2005-10-06 | バースタイン テクノロジーズ,インコーポレイティド | 光磁気バイオディスクおよび関連の方法を含むシステム |
| JP2008157923A (ja) | 2006-12-01 | 2008-07-10 | Canon Inc | 化学センシング装置及び化学センシング方法 |
| JP2008534972A (ja) | 2005-04-09 | 2008-08-28 | ベーリンガー インゲルハイム マイクロパーツ ゲゼルシャフト ミット ベシュレンクテル ハフツング | サンプル液の検査装置及び方法 |
| JP2008539419A (ja) | 2005-04-30 | 2008-11-13 | シェーン ユウ、ジャエ | バイオディスクおよびバイオドライバ装置、これを用いた分析方法 |
| US20080300148A1 (en) | 2007-06-04 | 2008-12-04 | Samsung Electronics Co., Ltd. | Microfluidic device for simultaneously conducting multiple analyses |
| JP2009520985A (ja) | 2005-12-21 | 2009-05-28 | ジェ・チャーン・ユ | バイオメモリディスク及びバイオメモリディスクドライブ装置及びそれを用いた分析方法 |
| US20110192726A1 (en) | 2008-10-31 | 2011-08-11 | Agency For Science ,Technology And Research | Device and method for detection of analyte from a sample |
| JP2011232328A (ja) | 2010-04-09 | 2011-11-17 | Hitachi Ltd | 生体物質検出アレイ、計測装置および計測方法 |
| JP2013220066A (ja) | 2012-04-17 | 2013-10-28 | Hitachi Ltd | センサチップ及びそれを用いた測定方法 |
| US20160299138A1 (en) | 2015-04-10 | 2016-10-13 | The Curators Of The University Of Missouri | High Sensitivity Impedance Sensor |
| JP2018009993A (ja) | 2012-01-27 | 2018-01-18 | ユニバーシティ オブ テネシー リサーチ ファウンデーション | 交流動電によるバイオマーカーの検出のための方法および装置 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998022819A1 (de) * | 1996-11-16 | 1998-05-28 | Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen In Reutlingen Stiftung Bürgerlichen Rechts | Mikroelementenanordnung, verfahren zum kontaktieren von in einer flüssigen umgebung befindlichen zellen und verfahren zum herstellen einer mikroelementenanordnung |
| US5922604A (en) * | 1997-06-05 | 1999-07-13 | Gene Tec Corporation | Thin reaction chambers for containing and handling liquid microvolumes |
| FR2787582B1 (fr) * | 1998-12-16 | 2001-01-12 | Commissariat Energie Atomique | Procede de fabrication d'une biopuce et biopuce |
| US20060068409A1 (en) * | 2000-11-27 | 2006-03-30 | Phan Brigitte C | Use of restriction enzymes and other chemical methods to decrease non-specific binding in dual bead assays and related bio-discs, methods, and system apparatus for detecting medical targets |
| GB0311902D0 (en) * | 2003-05-22 | 2003-06-25 | Cambridge Life Sciences | Assay method and apparatus |
| US7652768B2 (en) * | 2006-12-01 | 2010-01-26 | Canon Kabushiki Kaisha | Chemical sensing apparatus and chemical sensing method |
| KR100913148B1 (ko) * | 2007-04-10 | 2009-08-19 | 이금필 | 자성입자를 포함하는 자기력 기반 바이오 센서 |
| WO2009029073A1 (en) * | 2007-08-30 | 2009-03-05 | The Trustees Of Tufts College | Methods for determining the concentration of an analyte in solution. |
| GB2515490A (en) * | 2013-06-24 | 2014-12-31 | Univ Dublin City | An aperture array substrate device, a detection system and a method for detecting analytes in a sample |
| WO2015187792A1 (en) * | 2014-06-05 | 2015-12-10 | President And Fellows Of Harvard College | Protein analysis assay system |
| WO2017027384A1 (en) | 2015-08-07 | 2017-02-16 | Poc Medical Systems, Inc. | Microfluidic devices and methods of use thereof |
| US20170010259A1 (en) * | 2016-06-12 | 2017-01-12 | Ghassem Amoabediny | Multiplexed microfluidic proteomic platform |
-
2017
- 2017-04-03 GB GB1705328.1A patent/GB2561173A/en not_active Withdrawn
-
2018
- 2018-03-28 AU AU2018247760A patent/AU2018247760B2/en active Active
- 2018-03-28 EP EP18714243.5A patent/EP3606667B1/en active Active
- 2018-03-28 WO PCT/EP2018/057997 patent/WO2018184957A1/en not_active Ceased
- 2018-03-28 US US16/500,190 patent/US11406976B2/en active Active
- 2018-03-28 CA CA3058081A patent/CA3058081C/en active Active
- 2018-03-28 JP JP2019554648A patent/JP7202664B2/ja active Active
- 2018-03-28 ES ES18714243T patent/ES2992414T3/es active Active
- 2018-03-28 PL PL18714243.5T patent/PL3606667T3/pl unknown
-
2022
- 2022-07-05 US US17/857,824 patent/US11850588B2/en active Active
- 2022-12-06 AU AU2022283663A patent/AU2022283663B2/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005530127A (ja) | 2001-11-27 | 2005-10-06 | バースタイン テクノロジーズ,インコーポレイティド | 光磁気バイオディスクおよび関連の方法を含むシステム |
| JP2008534972A (ja) | 2005-04-09 | 2008-08-28 | ベーリンガー インゲルハイム マイクロパーツ ゲゼルシャフト ミット ベシュレンクテル ハフツング | サンプル液の検査装置及び方法 |
| JP2008539419A (ja) | 2005-04-30 | 2008-11-13 | シェーン ユウ、ジャエ | バイオディスクおよびバイオドライバ装置、これを用いた分析方法 |
| JP2009520985A (ja) | 2005-12-21 | 2009-05-28 | ジェ・チャーン・ユ | バイオメモリディスク及びバイオメモリディスクドライブ装置及びそれを用いた分析方法 |
| JP2008157923A (ja) | 2006-12-01 | 2008-07-10 | Canon Inc | 化学センシング装置及び化学センシング方法 |
| US20080300148A1 (en) | 2007-06-04 | 2008-12-04 | Samsung Electronics Co., Ltd. | Microfluidic device for simultaneously conducting multiple analyses |
| US20110192726A1 (en) | 2008-10-31 | 2011-08-11 | Agency For Science ,Technology And Research | Device and method for detection of analyte from a sample |
| JP2011232328A (ja) | 2010-04-09 | 2011-11-17 | Hitachi Ltd | 生体物質検出アレイ、計測装置および計測方法 |
| JP2018009993A (ja) | 2012-01-27 | 2018-01-18 | ユニバーシティ オブ テネシー リサーチ ファウンデーション | 交流動電によるバイオマーカーの検出のための方法および装置 |
| JP2013220066A (ja) | 2012-04-17 | 2013-10-28 | Hitachi Ltd | センサチップ及びそれを用いた測定方法 |
| US20160299138A1 (en) | 2015-04-10 | 2016-10-13 | The Curators Of The University Of Missouri | High Sensitivity Impedance Sensor |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018247760A1 (en) | 2019-11-07 |
| EP3606667C0 (en) | 2024-11-06 |
| AU2022283663B2 (en) | 2024-06-13 |
| US20210106991A1 (en) | 2021-04-15 |
| CA3058081A1 (en) | 2018-10-11 |
| EP3606667A1 (en) | 2020-02-12 |
| GB2561173A (en) | 2018-10-10 |
| AU2022283663A1 (en) | 2023-02-02 |
| JP2020515864A (ja) | 2020-05-28 |
| CA3058081C (en) | 2024-10-01 |
| US11850588B2 (en) | 2023-12-26 |
| GB201705328D0 (en) | 2017-05-17 |
| EP3606667B1 (en) | 2024-11-06 |
| WO2018184957A1 (en) | 2018-10-11 |
| PL3606667T3 (pl) | 2025-03-17 |
| AU2018247760B2 (en) | 2022-09-08 |
| US20230037522A1 (en) | 2023-02-09 |
| US11406976B2 (en) | 2022-08-09 |
| ES2992414T3 (es) | 2024-12-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2022283663B2 (en) | Microfluidic device for detection of analytes | |
| US9140697B2 (en) | Device for capturing circulating cells | |
| US11480567B2 (en) | Enhanced sensitivity and specificity for point-of-care (POC) micro biochip | |
| JP6317771B2 (ja) | 電気泳動分離装置およびそれを使用するための方法 | |
| CN107849738A (zh) | 用于进行免疫测定的系统和方法 | |
| US10481154B2 (en) | Biomarker detection and self-separation of serum during capillary flow | |
| Kim et al. | Highly sensitive three-dimensional interdigitated microelectrode biosensors embedded with porosity tunable hydrogel for detecting proteins | |
| CN110531065B (zh) | 一种基于水凝胶的微量全血分离和血浆检测一体化微流控芯片 | |
| Zhu et al. | Multiplex detection platform for tumor markers and glucose in serum based on a microfluidic microparticle array | |
| Srinivas et al. | Oil-isolated hydrogel microstructures for sensitive bioassays on-chip | |
| US20220291211A1 (en) | Microfluidic microparticle-labeled impedance sensor array for enhancing bioassay sensitivity | |
| KR101772766B1 (ko) | 마이크로칩과 이의 제조방법, 이를 이용한 효소 검출 시스템과 방법 | |
| JP2020515864A5 (https=) | ||
| Zhu et al. | PEG-based autonomous capillary system with integrated microbead array for immunoassay | |
| EP4592379A1 (en) | Method for forming microdroplets | |
| Bella et al. | Development of a miniaturized electrochemical biochip | |
| JP7503817B2 (ja) | 分析デバイス | |
| US20080160623A1 (en) | Method and device for bioanalyte quantification by on/off kinetics of binding complexes | |
| Zhang | Microfluidic Analysis of Exosomal Biomarkers Towards Liquid Biopsy Diagnosis of Alzheimer's Disease | |
| de Faria et al. | Development of a Microfluidic Device for the Isolation of Tumour-Derived Extracellular Vesicles | |
| Mansfield | Flow Valve Diagnostics for Label-Free, Quantitative Biomarker Detection: Device Fabrication, Surface Modification, and Testing | |
| Yang et al. | Fabricating small-scale polymeric structures for in-vitro diagnosis via daily-use tools | |
| Goldberg | Development of Microfluidic Devices with the Use of Nanotechnology to Aid in the Analysis of Biological Systems Including Membrane Protein Separation, Single Cell Analysis and Genetic Markers | |
| Nunna et al. | New Jersey Institute of Technology, NJIT 200 Central Ave, Newark, New Jersey, USA, eonsoo. lee@ njit. edu |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210329 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20210329 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20220119 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220125 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20220425 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220610 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220823 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20221012 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20221206 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20221219 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7202664 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |