JP7196157B2 - Ｃｎｓ状態の治療 - Google Patents

Ｃｎｓ状態の治療 Download PDF

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Publication number
JP7196157B2
JP7196157B2 JP2020511399A JP2020511399A JP7196157B2 JP 7196157 B2 JP7196157 B2 JP 7196157B2 JP 2020511399 A JP2020511399 A JP 2020511399A JP 2020511399 A JP2020511399 A JP 2020511399A JP 7196157 B2 JP7196157 B2 JP 7196157B2
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Japan
Prior art keywords
pharmaceutical composition
composition according
syndrome
benzyl
methanone
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JP2020511399A
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English (en)
Japanese (ja)
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JP2020532508A (ja
JP2020532508A5 (https=
Inventor
俊哉 西
伸一 近藤
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Publication of JP2020532508A publication Critical patent/JP2020532508A/ja
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Priority to JP2022199076A priority Critical patent/JP7469445B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
JP2020511399A 2017-08-31 2018-08-30 Ｃｎｓ状態の治療 Active JP7196157B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022199076A JP7469445B2 (ja) 2017-08-31 2022-12-14 Ｃｎｓ状態の治療

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762553070P 2017-08-31 2017-08-31
US62/553,070 2017-08-31
PCT/JP2018/032949 WO2019045121A1 (en) 2017-08-31 2018-08-30 TREATMENT OF CNS DISEASES

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022199076A Division JP7469445B2 (ja) 2017-08-31 2022-12-14 Ｃｎｓ状態の治療

Publications (3)

Publication Number Publication Date
JP2020532508A JP2020532508A (ja) 2020-11-12
JP2020532508A5 JP2020532508A5 (https=) 2021-09-30
JP7196157B2 true JP7196157B2 (ja) 2022-12-26

Family

ID=63722720

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020511399A Active JP7196157B2 (ja) 2017-08-31 2018-08-30 Ｃｎｓ状態の治療
JP2022199076A Active JP7469445B2 (ja) 2017-08-31 2022-12-14 Ｃｎｓ状態の治療

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022199076A Active JP7469445B2 (ja) 2017-08-31 2022-12-14 Ｃｎｓ状態の治療

Country Status (8)

Country Link
US (4) US11285139B2 (https=)
EP (1) EP3675852A1 (https=)
JP (2) JP7196157B2 (https=)
KR (1) KR102680786B1 (https=)
CN (2) CN116370475A (https=)
CA (1) CA3073925A1 (https=)
MX (1) MX2020001732A (https=)
WO (1) WO2019045121A1 (https=)

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EP3572417B1 (en) 2011-10-14 2025-12-17 Sage Therapeutics, LLC 3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof
EP2986624B1 (en) 2013-04-17 2020-03-25 Sage Therapeutics, Inc. 19-nor neuroactive steroids for methods of treatment
US9725481B2 (en) 2013-04-17 2017-08-08 Sage Therapeutics, Inc. 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
US20160068563A1 (en) 2013-04-17 2016-03-10 Boyd L. Harrison 19-nor neuroactive steroids and methods of use thereof
KR102396328B1 (ko) 2013-04-17 2022-05-10 세이지 테라퓨틱스, 인크. 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
SI3021852T1 (sl) 2013-07-19 2021-07-30 Sage Therapeutics, Inc. Nevroaktivni steroidi, sestavki in uporabe le-teh
AU2014308621C1 (en) 2013-08-23 2022-01-06 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
ME03809B (me) 2014-10-16 2021-04-20 Sage Therapeutics Inc KOMPOZICIJE I POSTUPCI ZA LEČENJE POREMEĆAJA CNS-a
CN117024501A (zh) 2014-10-16 2023-11-10 萨奇治疗股份有限公司 靶向cns障碍的组合物和方法
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
RS61530B1 (sr) 2015-01-26 2021-04-29 Sage Therapeutics Inc Kompozicije i postupci za lečenje poremećaja cns
EP4155314A1 (en) 2015-02-20 2023-03-29 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
WO2018013615A1 (en) 2016-07-11 2018-01-18 Sage Therapeutics, Inc. C7, c12, and c16 substituted neuroactive steroids and their methods of use
MA45599A (fr) 2016-07-11 2019-05-15 Sage Therapeutics Inc Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation
EP3504189A1 (en) 2016-08-23 2019-07-03 Sage Therapeutics, Inc. A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid
MX2020004972A (es) 2017-11-14 2020-08-24 Sk Biopharmaceuticals Co Ltd Uso de compuesto de carbamato para prevenir, aliviar o tratar ataque de ausencia o epilepsia que muestra ataque de ausencia.
US20210161808A1 (en) * 2018-07-24 2021-06-03 Zenvision Pharma Llp Nasal Drug Delivery System of Brivaracetam or Salt Thereof
GB2580881A (en) * 2018-11-30 2020-08-05 Gw Res Ltd Use of cannabinoids in the treatment of epilepsy
SG11202112391UA (en) 2019-05-31 2021-12-30 Sage Therapeutics Inc Neuroactive steroids and compositions thereof
EP4069685A1 (en) * 2019-12-02 2022-10-12 F. Hoffmann-La Roche AG Alkynyl-(heteroaryl)-carboxamide hcn1 inhibitors
GB2597312A (en) 2020-07-20 2022-01-26 Gw Res Ltd Use of cannabidiol in the treatment of seizures associated with rare epilepsy syndromes related to genetic abnormalities
GB2597285A (en) * 2020-07-20 2022-01-26 Gw Res Ltd Use of cannabidiol in the treatment of seizures associated with rare epilepsy syndromes related to genetic abnormalities
GB2597311A (en) * 2020-07-20 2022-01-26 Gw Res Ltd Use of cannabidiol in the treatment of seizures associated with rare epilepsy syndromes related to genetic abnormalities
WO2022217066A1 (en) * 2021-04-09 2022-10-13 The Johns Hopkins University Treatment methods and compositions comprising perampanel
CN115487144A (zh) * 2021-06-18 2022-12-20 北京万全德众医药生物技术有限公司 一种卢非酰胺的口服液制备方法
US20250213547A1 (en) * 2022-03-18 2025-07-03 Takeda Pharmaceutical Company Limited Methods of treating neurological diseases
WO2024100531A1 (en) * 2022-11-07 2024-05-16 Takeda Pharmaceutical Company Limited Method of treating seizure disorders
WO2025126159A1 (en) * 2023-12-15 2025-06-19 Takeda Pharmaceutical Company Limited A method for treating a neurological disease in a recreational drug user
WO2025257799A1 (en) * 2024-06-14 2025-12-18 Takeda Pharmaceutical Company Limited Methods of treating dravet syndrome
CN121550436A (zh) * 2026-01-23 2026-02-24 四川大学华西医院 新靶点在结节性硬化症相关癫痫中的应用、组合物及联合用药方式

Citations (3)

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WO2014092100A1 (ja) 2012-12-11 2014-06-19 武田薬品工業株式会社 複素環化合物
WO2014163161A1 (ja) 2013-04-04 2014-10-09 武田薬品工業株式会社 複素環化合物
JP2014528904A (ja) 2011-10-07 2014-10-30 武田薬品工業株式会社 神経変性疾患の治療に有用な１−アリールカルボニル−４−オキシ−ピペリジン化合物

Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
US10562881B2 (en) 2015-10-16 2020-02-18 Takeda Pharmaceutical Company Limited Method for producing heterocyclic compound

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014528904A (ja) 2011-10-07 2014-10-30 武田薬品工業株式会社 神経変性疾患の治療に有用な１−アリールカルボニル−４−オキシ−ピペリジン化合物
WO2014092100A1 (ja) 2012-12-11 2014-06-19 武田薬品工業株式会社 複素環化合物
WO2014163161A1 (ja) 2013-04-04 2014-10-09 武田薬品工業株式会社 複素環化合物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Study of TAK-935 as an Adjunctive Therapy in Participants With developmental and/or Epileptic Encephalopathies，Clinical Trials.gov archive，2017年08月28日，NCT03166215
Takeda，Takeda and Ovid Therapeutics Announce Innovative Clinical Development and Commercialization Collaboration for TAK-935 in Rare Pediatric Epilepsies，2017年01月18日，https://www.takeda.com/newsroom/newsreleases/2017/Takeda-and-Ovid-Therapeutics-Announce-Innovative-Clinical-Development-and-Commercialization/

Also Published As

Publication number Publication date
JP2020532508A (ja) 2020-11-12
US20220168294A1 (en) 2022-06-02
JP7469445B2 (ja) 2024-04-16
KR102680786B1 (ko) 2024-07-02
US20200306238A1 (en) 2020-10-01
WO2019045121A1 (en) 2019-03-07
CN111065394A (zh) 2020-04-24
JP2023027267A (ja) 2023-03-01
KR20200046022A (ko) 2020-05-06
CN111065394B (zh) 2023-03-31
MX2020001732A (es) 2020-03-20
US11285139B2 (en) 2022-03-29
CN116370475A (zh) 2023-07-04
EP3675852A1 (en) 2020-07-08
US20230087903A1 (en) 2023-03-23
CA3073925A1 (en) 2019-03-07
US20250281477A1 (en) 2025-09-11

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