JP7153969B1 - 抗菌剤 - Google Patents
抗菌剤 Download PDFInfo
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- JP7153969B1 JP7153969B1 JP2021192239A JP2021192239A JP7153969B1 JP 7153969 B1 JP7153969 B1 JP 7153969B1 JP 2021192239 A JP2021192239 A JP 2021192239A JP 2021192239 A JP2021192239 A JP 2021192239A JP 7153969 B1 JP7153969 B1 JP 7153969B1
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- antibacterial agent
- sorboside
- antibacterial
- sorbose
- bacteria
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- 239000003242 anti bacterial agent Substances 0.000 title claims abstract description 132
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Images
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
(1)有効成分として式(I):
で表わされるソルボシド化合物および式(II):
を含有してなる抗菌剤、
(2) 前記(1)に記載の抗菌剤を含有してなる皮膚外用剤、
(3) 前記(1)に記載の抗菌剤を含有してなる防腐剤、および
(4) 前記(1)に記載の抗菌剤を含有してなる口腔用剤
に関する。
で表わされるソルボシド化合物(以下、単にソルボシド化合物という)および式(II):
を含有する。
L-ソルボース〔ナカライテスク(株)製〕5.0g、酸触媒として10%塩酸1滴(約0.3mL)およびメタノール50mLを500mL容のフラスコ内に入れ、15~100℃の温度で10時間撹拌することにより、L-ソルボースとメタノールとを反応させ、式(I)において、R1がメチル基であるソルボシド化合物のメタノール溶液を得た。
調製例1において、メタノール50mLの代わりにエタノール50mLを用いたこと以外は、調製例1と同様の操作を行なうことによりソルボシド化合物を得た。なお、得られたソルボシド化合物が、式(I)においてR1がエチル基であるソルボシド化合物(エチル-L-ソルボシド)であることは、1H-NMRによる分析およびHPLCによる分析によって確認した。
調製例1で得られたソルボシド化合物とL-ソルボースとを表1に示す量比で混合することにより、抗菌剤を調製した。
抗菌剤として、L-ソルボースのみを使用した。
抗菌剤として、調製例1で得られたソルボシド化合物のみを用いた。
抗菌剤の抗菌性として抗菌剤を使用したときの菌の生育度および抗菌剤による菌の生育阻害性を以下の方法に基づいて評価した。
抗菌剤をイオン交換水に溶解させ、抗菌剤の含有率が15質量%である水性抗菌剤を調製した。
菌の生育度は、濁度法によって求めた。より具体的には、コリネバクテリウムを48時間培養した後、可視分光光度計(サーモフィッシャーサイエンティフィック社製、商品名:SPECTRONIC200)を用い、波長600nmにて吸光度を測定し、当該吸光度の値を菌の生育度の指標とした。その結果を表1に示す。なお、菌の生育度が低くなるにしたがって吸光度が低くなる。
前記菌の生育度の測定方法に準じて波長600nmにおける吸光度を測定し、式:
[菌の生育阻害率(%)]
=100-{[抗菌剤を添加したときの吸光度]÷[抗菌剤が添加されていないときの吸光度]×100
に基づいて菌の生育阻害率を求めた。
実施例3、比較例1および比較例2で得られた各抗菌剤を用い、各抗菌剤をそれぞれイオン交換水に溶解させ、抗菌剤の含有率が0.5質量%である水性抗菌剤を調製した。
実施例3および比較例2で得られた各抗菌剤を用い、各抗菌剤をそれぞれイオン交換水に溶解させ、抗菌剤の含有率が0.5質量%または1.0質量%である水性抗菌剤を調製した。
調製例2で得られたソルボシド化合物とL-ソルボースとを60/40の質量比(ソルボシド化合物/L-ソルボース)で混合することにより、抗菌剤を調製した。
実施例4で得られた抗菌剤および比較例2で得られた抗菌剤を用い、各抗菌剤をそれぞれイオン交換水に溶解させ、抗菌剤の含有率が0.5質量%である水性抗菌剤を調製した。
実施例3で得られた抗菌剤および比較例2で得られた抗菌剤を用い、各抗菌剤をそれぞれイオン交換水に溶解させ、抗菌剤の含有率が1質量%である水性抗菌剤を調製した。
実施例3で得られた抗菌剤および比較例2で得られた抗菌剤を用い、各抗菌剤をそれぞれイオン交換水に溶解させ、抗菌剤の含有率が1質量%である水性抗菌剤を調製した。
実施例2で得られた抗菌剤および実施例4で得られた抗菌剤を用い、各抗菌剤をそれぞれイオン交換水に溶解させ、抗菌剤の含有率が0.5質量%、1.0質量%、2.0質量%または3.0質量%である水性抗菌剤を調製した。
A:菌の生育がほとんど認められないことから菌の生育阻害効果に優れている。
B:菌の生育の阻害効果が僅かに認められる。
C:菌の生育の阻害効果がやや認められる
D:菌の生育の阻害効果が認められない。
各実施例で得られた抗菌剤を用い、前記と同様にしてプロピオニバクテリウム(ニキビ菌)、コリネバクテリウム(加齢臭原因菌)、ミュータンス菌(虫歯菌)に対する抗菌性として菌の生育度および菌の育成阻害性を前記と同様にして調べた。その結果、各実施例で得られた抗菌剤は、いずれも、抗菌スペクトルが異なるが、プロピオニバクテリウム(ニキビ菌)、コリネバクテリウム(加齢臭原因菌)、トリコフィトン(水虫菌)、ミュータンス菌(虫歯菌)などの菌体に対し、強力な生育阻害作用を有するという、他の抗菌剤では見られない特異的効果が奏されることが確認された。この効果は、ソルボースではまったく発現されなかったことから、当該ソルボースから予期することができない顕著に優れた斬新な効果であることが確認された。
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