JP7146739B2 - 癌を処置するためのアデノウイルスとチェックポイント阻害剤の組合せ - Google Patents

癌を処置するためのアデノウイルスとチェックポイント阻害剤の組合せ Download PDF

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JP7146739B2
JP7146739B2 JP2019513967A JP2019513967A JP7146739B2 JP 7146739 B2 JP7146739 B2 JP 7146739B2 JP 2019513967 A JP2019513967 A JP 2019513967A JP 2019513967 A JP2019513967 A JP 2019513967A JP 7146739 B2 JP7146739 B2 JP 7146739B2
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cancer
oncos
virus
tumor
adenovirus
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JP2019532047A (ja
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トゥーリ ランキ
サリ ペソネン
マグヌス イェーデルベルク
エリナ ハーヴィスト
ウカシュ クリュク
アンッティ ヴオラント
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タルゴヴァックス オサケ ユキチュア
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

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  • Immunology (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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JP2019513967A 2016-09-12 2017-09-11 癌を処置するためのアデノウイルスとチェックポイント阻害剤の組合せ Expired - Fee Related JP7146739B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022150036A JP2022183170A (ja) 2016-09-12 2022-09-21 癌を処置するためのアデノウイルスとチェックポイント阻害剤の組合せ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16188301.2A EP3293201B1 (en) 2016-09-12 2016-09-12 Combining adenovirus and checkpoint inhibitors for treating cancer
EP16188301.2 2016-09-12
PCT/FI2017/050645 WO2018046803A1 (en) 2016-09-12 2017-09-11 Combining adenovirus and checkpoint inhibitors for treating cancer

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JP2022150036A Division JP2022183170A (ja) 2016-09-12 2022-09-21 癌を処置するためのアデノウイルスとチェックポイント阻害剤の組合せ

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JP2019532047A JP2019532047A (ja) 2019-11-07
JP2019532047A5 JP2019532047A5 (enExample) 2020-10-22
JP7146739B2 true JP7146739B2 (ja) 2022-10-04

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JP2019513967A Expired - Fee Related JP7146739B2 (ja) 2016-09-12 2017-09-11 癌を処置するためのアデノウイルスとチェックポイント阻害剤の組合せ
JP2022150036A Pending JP2022183170A (ja) 2016-09-12 2022-09-21 癌を処置するためのアデノウイルスとチェックポイント阻害剤の組合せ

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US (2) US10940203B2 (enExample)
EP (2) EP3783032A1 (enExample)
JP (2) JP7146739B2 (enExample)
CN (1) CN109715664A (enExample)
AU (1) AU2017324482A1 (enExample)
DK (1) DK3293201T3 (enExample)
ES (1) ES2845690T3 (enExample)
HR (1) HRP20210133T1 (enExample)
HU (1) HUE053236T2 (enExample)
LT (1) LT3293201T (enExample)
PL (1) PL3293201T3 (enExample)
PT (1) PT3293201T (enExample)
SI (1) SI3293201T1 (enExample)
WO (1) WO2018046803A1 (enExample)

Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
US10350275B2 (en) * 2013-09-21 2019-07-16 Advantagene, Inc. Methods of cytotoxic gene therapy to treat tumors
US11090344B2 (en) 2016-05-27 2021-08-17 Dnatrix, Inc. Adenovirus and immunomodulator combination therapy
EP3534923A4 (en) * 2016-11-01 2020-05-27 DNAtrix, Inc. COMBINATION THERAPY FOR THE TREATMENT OF BRAIN CARCINOMAS
GB201804473D0 (en) * 2018-03-21 2018-05-02 Valo Therapeutics Oy Modified oncolytic adenoviruses
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
EP4061405A1 (en) 2019-11-18 2022-09-28 Janssen Biotech, Inc. Vaccines based on mutant calr and jak2 and their uses
EP4175664A2 (en) 2020-07-06 2023-05-10 Janssen Biotech, Inc. Prostate neoantigens and their uses
WO2022009049A1 (en) 2020-07-06 2022-01-13 Janssen Biotech, Inc. Prostate neoantigens and their uses
CN114426945B (zh) * 2021-11-10 2024-08-23 西安交通大学医学院第一附属医院 胶质瘤类器官原代促活液、培养液及制备、培养方法
CN121335710A (zh) * 2023-04-07 2026-01-13 上海复诺健生物科技有限公司 重组溶瘤病毒与检查点抑制剂的组合用于治疗癌症

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
ES2304281B1 (es) * 2006-02-01 2009-08-12 Dnatrix Inc. Adenovirus oncoliticos para el tratamiento del cancer.
BRPI0924123B8 (pt) 2008-12-22 2021-05-25 Oncos Therapeutics Oy vetores adenovirais oncolíticos, usos dos mesmos, composição farmacêutica e método para produzir gmcsf em uma célula in vitro
FI20090030A0 (fi) * 2009-02-02 2009-02-02 Akseli Eetu Hemminki Onkolyyttiset virukset
EA201590451A1 (ru) 2012-08-30 2016-05-31 Эмджен Инк. Способ лечения меланомы с применением вируса простого герпеса и ингибитора иммунной контрольной точки
US20150250837A1 (en) 2012-09-20 2015-09-10 Morningside Technology Ventures Ltd. Oncolytic virus encoding pd-1 binding agents and uses of the same
US10350275B2 (en) 2013-09-21 2019-07-16 Advantagene, Inc. Methods of cytotoxic gene therapy to treat tumors
CN114317461A (zh) * 2013-11-22 2022-04-12 德那翠丝有限公司 表达免疫细胞刺激受体激动剂的腺病毒

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Clinical Advances in Hematology and Oncology，2016年08月，Vol.4, No.8，pp.576-579
Journal for ImmunoTherapy of Cancer，2016年03月15日，Vol.4, No.17，pp.1-18

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Publication number Publication date
LT3293201T (lt) 2021-03-25
DK3293201T3 (da) 2020-12-07
EP3293201A1 (en) 2018-03-14
WO2018046803A1 (en) 2018-03-15
CN109715664A (zh) 2019-05-03
US20210121564A1 (en) 2021-04-29
HUE053236T2 (hu) 2021-06-28
JP2019532047A (ja) 2019-11-07
EP3783032A1 (en) 2021-02-24
US20190201525A1 (en) 2019-07-04
JP2022183170A (ja) 2022-12-08
US10940203B2 (en) 2021-03-09
AU2017324482A1 (en) 2019-04-11
PL3293201T3 (pl) 2021-06-14
US11690913B2 (en) 2023-07-04
SI3293201T1 (sl) 2021-03-31
PT3293201T (pt) 2020-12-07
HRP20210133T1 (hr) 2021-03-19
EP3293201B1 (en) 2020-11-04
ES2845690T3 (es) 2021-07-27

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