JP7133544B2 - 親和性を操作した血清タンパク質担体結合ドメイン - Google Patents

親和性を操作した血清タンパク質担体結合ドメイン Download PDF

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JP7133544B2
JP7133544B2 JP2019508294A JP2019508294A JP7133544B2 JP 7133544 B2 JP7133544 B2 JP 7133544B2 JP 2019508294 A JP2019508294 A JP 2019508294A JP 2019508294 A JP2019508294 A JP 2019508294A JP 7133544 B2 JP7133544 B2 JP 7133544B2
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disease
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binding
hsa
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JP2019516785A5 (enExample
JP2019516785A (ja
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アダムズ、ラルフ
フィリップ ヘイウッド、サム
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ユーシービー バイオファルマ エスアールエル
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JP2019508294A 2016-05-01 2017-04-28 親和性を操作した血清タンパク質担体結合ドメイン Active JP7133544B2 (ja)

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GBGB1607636.6A GB201607636D0 (en) 2016-05-01 2016-05-01 Molecules & method
GB1607636.6 2016-05-01
GBGB1607828.9A GB201607828D0 (en) 2016-05-04 2016-05-04 Method
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PCT/EP2017/060266 WO2017191062A1 (en) 2016-05-01 2017-04-28 Affinity engineered serum protein carrier binding domain

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EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
GB201811368D0 (en) * 2018-07-11 2018-08-29 Ucb Biopharma Sprl Antibody
EP3930687A4 (en) 2019-02-25 2023-06-07 The University of Chicago METHODS AND COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS USING ECM AFFINITY PEPTIDES LINKED TO ANTI-INFLAMMATORY AGENTS
EP3904378A1 (en) * 2020-04-29 2021-11-03 Hober Biotech AB Bispecific protein
CA3198049A1 (en) 2020-10-15 2022-04-21 UCB Biopharma SRL Binding molecules that multimerise cd45
GB202318820D0 (en) 2023-12-08 2024-01-24 UCB Biopharma SRL Antibodies

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JP2012503638A (ja) 2008-09-26 2012-02-09 ユセベ ファルマ ソシエテ アノニム 生物学的産物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
GB9113120D0 (en) 1991-06-18 1991-08-07 Kodak Ltd Photographic processing apparatus
PT1644412E (pt) 2003-07-01 2015-12-23 Ucb Biopharma Sprl Fragmentos de anticorpos fab modificados
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0411186D0 (en) 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
EP2535350B1 (en) * 2007-09-26 2018-01-24 UCB Biopharma SPRL Dual specificity antibody fusions
JP6411214B2 (ja) * 2011-11-11 2018-10-24 ユーシービー バイオファルマ エスピーアールエル アルブミン結合抗体及びその結合断片
GB201223276D0 (en) * 2012-12-21 2013-02-06 Ucb Pharma Sa Antibodies and methods of producing same
WO2015006337A2 (en) * 2013-07-08 2015-01-15 Nanjingjinsirui Science & Technology Biology Corporation Compositions and methods for increasing protein half-life in a serum
GB201411320D0 (en) 2014-06-25 2014-08-06 Ucb Biopharma Sprl Antibody construct

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012503638A (ja) 2008-09-26 2012-02-09 ユセベ ファルマ ソシエテ アノニム 生物学的産物

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