CN109071643B - 亲和力改造的血清蛋白载体结合结构域 - Google Patents

亲和力改造的血清蛋白载体结合结构域 Download PDF

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CN109071643B
CN109071643B CN201780027100.5A CN201780027100A CN109071643B CN 109071643 B CN109071643 B CN 109071643B CN 201780027100 A CN201780027100 A CN 201780027100A CN 109071643 B CN109071643 B CN 109071643B
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disease
binding
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binding domain
fab
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CN109071643A (zh
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R·亚当斯
S·P·海伍德
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UCB Biopharma SRL
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CN201780027100.5A 2016-05-01 2017-04-28 亲和力改造的血清蛋白载体结合结构域 Active CN109071643B (zh)

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GB1607636.6 2016-05-01
GBGB1607636.6A GB201607636D0 (en) 2016-05-01 2016-05-01 Molecules & method
GB1607828.9 2016-05-04
GBGB1607828.9A GB201607828D0 (en) 2016-05-04 2016-05-04 Method
PCT/EP2017/060266 WO2017191062A1 (en) 2016-05-01 2017-04-28 Affinity engineered serum protein carrier binding domain

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EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
GB201811368D0 (en) * 2018-07-11 2018-08-29 Ucb Biopharma Sprl Antibody
WO2020176478A1 (en) 2019-02-25 2020-09-03 The University Of Chicago Methods and compositions for treating inflammatory and autoimmune conditions with ecm-affinity peptides linked to anti-inflammatory agents
CA3198049A1 (en) 2020-10-15 2022-04-21 UCB Biopharma SRL Binding molecules that multimerise cd45
GB202318820D0 (en) 2023-12-08 2024-01-24 UCB Biopharma SRL Antibodies

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101842387A (zh) * 2007-09-26 2010-09-22 Ucb医药有限公司 双特异性抗体融合物
CN103946237A (zh) * 2011-11-11 2014-07-23 Ucb医药有限公司 白蛋白结合抗体及其结合片段
WO2015006337A2 (en) * 2013-07-08 2015-01-15 Nanjingjinsirui Science & Technology Biology Corporation Compositions and methods for increasing protein half-life in a serum
CN105026431A (zh) * 2012-12-21 2015-11-04 Ucb生物制药私人有限公司 单接头FabFv抗体和制备其的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
GB9113120D0 (en) 1991-06-18 1991-08-07 Kodak Ltd Photographic processing apparatus
DK1644412T4 (en) 2003-07-01 2018-11-12 Ucb Biopharma Sprl MODIFIED ANTIBODY-FAB FRAGMENTS
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0411186D0 (en) 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
SI2334705T1 (sl) 2008-09-26 2017-05-31 Ucb Biopharma Sprl Biološki produkti
GB201411320D0 (en) 2014-06-25 2014-08-06 Ucb Biopharma Sprl Antibody construct

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101842387A (zh) * 2007-09-26 2010-09-22 Ucb医药有限公司 双特异性抗体融合物
CN104004088A (zh) * 2007-09-26 2014-08-27 Ucb医药有限公司 双特异性抗体融合物
CN103946237A (zh) * 2011-11-11 2014-07-23 Ucb医药有限公司 白蛋白结合抗体及其结合片段
CN105026431A (zh) * 2012-12-21 2015-11-04 Ucb生物制药私人有限公司 单接头FabFv抗体和制备其的方法
WO2015006337A2 (en) * 2013-07-08 2015-01-15 Nanjingjinsirui Science & Technology Biology Corporation Compositions and methods for increasing protein half-life in a serum

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Albumin as a versatile platform for drug half-life extension;Darrell Sleep等;《Biochimica et Biophysica Acta》;20130429;第1830卷;第5526-5534页 *
Albumin Binding as a General Strategy for Improving the Pharmacokinetics of Proteins;Mark S. Dennis等;《THE JOURNAL OF BIOLOGICAL CHEMISTRY》;20020920;第277卷(第38期);第35035-35043页 *
Anti-serum albumin domain antibodies for extending the half-lives of short lived drugs;Lucy J. Holt等;《Protein Engineering, Design & Selection》;20080402;第21卷(第5期);第283-288页 *
New Strategy for the Extension of the Serum Half-Life of Antibody Fragments;Sabrina Trussel等;《Bioconjugate Chem.》;20091116;第20卷;第2286-2292页 *
The effects of affinity and valency of an albumin-binding domain (ABD) on the half-life of a single-chain diabody-ABD fusion protein;Jonas Hopp等;《Protein Engineering, Design & Selection》;20100903;第23卷(第11期);第827-834页 *
The pharmacokinetics of an albumin-binding Fab (AB.Fab) can be modulated as a function of affinity for albumin;Allen Nguyen等;《Protein Engineering, Design & Selection》;20060418;第19卷(第7期);第291-297页 *

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