JP7125828B2 - フタロシアニン色素化合物、コンジュゲート及びその使用方法 - Google Patents

フタロシアニン色素化合物、コンジュゲート及びその使用方法 Download PDF

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JP7125828B2
JP7125828B2 JP2021571480A JP2021571480A JP7125828B2 JP 7125828 B2 JP7125828 B2 JP 7125828B2 JP 2021571480 A JP2021571480 A JP 2021571480A JP 2021571480 A JP2021571480 A JP 2021571480A JP 7125828 B2 JP7125828 B2 JP 7125828B2
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JP2022527672A (ja
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ベタンコルト、フアン
メイキングス、ルー
ウィーマン、トルステン
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Rakuten Medical Inc
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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B47/00—Porphines; Azaporphines
    • C09B47/04—Phthalocyanines abbreviation: Pc
    • C09B47/30—Metal-free phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B47/00—Porphines; Azaporphines
    • C09B47/04—Phthalocyanines abbreviation: Pc
    • C09B47/08—Preparation from other phthalocyanine compounds, e.g. cobaltphthalocyanineamine complex
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B47/00—Porphines; Azaporphines
    • C09B47/04—Phthalocyanines abbreviation: Pc
    • C09B47/32—Cationic phthalocyanine dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/008—Dyes containing a substituent, which contains a silicium atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E10/00—Energy generation through renewable energy sources
    • Y02E10/50—Photovoltaic [PV] energy
    • Y02E10/542—Dye sensitized solar cells

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Radiation-Therapy Devices (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2021571480A 2020-04-10 2021-04-09 フタロシアニン色素化合物、コンジュゲート及びその使用方法 Active JP7125828B2 (ja)

Priority Applications (2)

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JP2022126602A JP2022191209A (ja) 2020-04-10 2022-08-08 フタロシアニン色素化合物、コンジュゲート及びその使用方法
JP2022128871A JP7900220B2 (ja) 2020-04-10 2022-08-12 フタロシアニン色素化合物、コンジュゲート及びその使用方法

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US202063008476P 2020-04-10 2020-04-10
US202063008502P 2020-04-10 2020-04-10
US63/008,502 2020-04-10
US63/008,476 2020-04-10
PCT/US2021/026705 WO2021207691A1 (en) 2020-04-10 2021-04-09 Phthalocyanine dye compounds, conjugates and methods of use thereof

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JP2022126602A Division JP2022191209A (ja) 2020-04-10 2022-08-08 フタロシアニン色素化合物、コンジュゲート及びその使用方法
JP2022128871A Division JP7900220B2 (ja) 2020-04-10 2022-08-12 フタロシアニン色素化合物、コンジュゲート及びその使用方法

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JP7125828B2 true JP7125828B2 (ja) 2022-08-25

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JP2022126602A Pending JP2022191209A (ja) 2020-04-10 2022-08-08 フタロシアニン色素化合物、コンジュゲート及びその使用方法
JP2022128871A Active JP7900220B2 (ja) 2020-04-10 2022-08-12 フタロシアニン色素化合物、コンジュゲート及びその使用方法

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JP2022128871A Active JP7900220B2 (ja) 2020-04-10 2022-08-12 フタロシアニン色素化合物、コンジュゲート及びその使用方法

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US (2) US11466158B2 (enExample)
EP (1) EP4132583A4 (enExample)
JP (3) JP7125828B2 (enExample)
KR (1) KR20230009890A (enExample)
CN (1) CN115942958A (enExample)
AU (1) AU2021251873A1 (enExample)
BR (1) BR112022020521A2 (enExample)
CA (1) CA3179937A1 (enExample)
MX (1) MX2022012721A (enExample)
WO (1) WO2021207691A1 (enExample)

Cited By (1)

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JP2022191210A (ja) * 2020-04-10 2022-12-27 ラクテン・メディカル，インコーポレイテッド フタロシアニン色素化合物、コンジュゲート及びその使用方法

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CN115003679A (zh) * 2020-02-05 2022-09-02 国立大学法人东京大学 酞菁染料与抗体或肽的缀合物
WO2022182483A1 (en) 2021-02-02 2022-09-01 Rakuten Medical, Inc. Methods for local and systemic treatment of cancers, tumors and tumor cells
EP4319817A4 (en) * 2021-04-09 2026-05-27 Rakuten Medical Inc PHTHALOCYANINE-BASED COLOUR COMPOUNDS, CONJUGATES AND ASSOCIATED PROCESSES OF USE
US12115223B2 (en) 2021-04-22 2024-10-15 The University Of Tokyo Conjugate of biotin-modified dimer and phthalocyanine dye
CN113943305B (zh) * 2021-11-15 2022-12-30 中国科学技术大学 酞菁荧光分子化合物、制备方法、酞菁荧光纳米材料
CA3252736A1 (en) 2022-02-18 2023-08-24 Rakuten Medical, Inc. Anti-PD-L1 (Programmed Death-Ligand 1) Antibody Molecules, Coding Polynucleotides, and Methods of Use
US20260176317A1 (en) 2022-11-11 2026-06-25 Rakuten Medical, Inc. Engineered interleukin-15 polypeptides, complexes and uses thereof
EP4435060A1 (en) 2023-03-23 2024-09-25 Albert-Ludwigs-Universität Freiburg Silicon phthalocyanine and tribenzophthalocyanine dyes and their use in diagnosis and therapy
WO2025035196A1 (pt) * 2023-08-11 2025-02-20 Use Phitta Cream Ltda - Epp Creme hidratante com proteção antisséptica de ação prolongada para as mãos

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CN1583762A (zh) 2004-06-11 2005-02-23 福州大学 新的轴向取代酞菁配合物、它的制备及其在光动力治疗中的应用
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US20040171827A1 (en) 2002-10-25 2004-09-02 Li-Cor, Inc. Phthalocyanine dyes
CN1583762A (zh) 2004-06-11 2005-02-23 福州大学 新的轴向取代酞菁配合物、它的制备及其在光动力治疗中的应用
CN103539799A (zh) 2013-08-29 2014-01-29 中国医学科学院生物医学工程研究所 一种水溶性氨基多羧酸修饰酞菁化合物的制备方法和用途
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022191210A (ja) * 2020-04-10 2022-12-27 ラクテン・メディカル，インコーポレイテッド フタロシアニン色素化合物、コンジュゲート及びその使用方法
JP7900220B2 (ja) 2020-04-10 2026-08-04 ラクテン・メディカル，インコーポレイテッド フタロシアニン色素化合物、コンジュゲート及びその使用方法

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CA3179937A1 (en) 2021-10-14
US20220010140A1 (en) 2022-01-13
WO2021207691A1 (en) 2021-10-14
AU2021251873A1 (en) 2022-11-10
US11466158B2 (en) 2022-10-11
EP4132583A4 (en) 2024-11-13
EP4132583A1 (en) 2023-02-15
JP7900220B2 (ja) 2026-08-04
CN115942958A (zh) 2023-04-07
JP2022191210A (ja) 2022-12-27
MX2022012721A (es) 2023-01-16
JP2022191209A (ja) 2022-12-27
BR112022020521A2 (pt) 2023-03-07
KR20230009890A (ko) 2023-01-17
US12448518B2 (en) 2025-10-21
US20230399515A1 (en) 2023-12-14
JP2022527672A (ja) 2022-06-02

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