JP7110232B2 - フェニル－２－ヒドロキシ－アセチルアミノ－２－メチル－フェニル化合物 - Google Patents

フェニル－２－ヒドロキシ－アセチルアミノ－２－メチル－フェニル化合物 Download PDF

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JP7110232B2
JP7110232B2 JP2019556703A JP2019556703A JP7110232B2 JP 7110232 B2 JP7110232 B2 JP 7110232B2 JP 2019556703 A JP2019556703 A JP 2019556703A JP 2019556703 A JP2019556703 A JP 2019556703A JP 7110232 B2 JP7110232 B2 JP 7110232B2
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methyl
amino
compound
pharmaceutically acceptable
acceptable salt
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JP2021517555A (ja
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マルタ マリア シフエンテス－ガルシア，
マリア クリスティナ ガルシア－パレデス，
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イーライ リリー アンド カンパニー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2019556703A 2017-04-18 2018-04-11 フェニル－２－ヒドロキシ－アセチルアミノ－２－メチル－フェニル化合物 Active JP7110232B2 (ja)

Priority Applications (1)

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JP2022115300A JP7331212B2 (ja) 2017-04-18 2022-07-20 フェニル－２－ヒドロキシ－アセチルアミノ－２－メチル－フェニル化合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17382207 2017-04-18
EP17382207.3 2017-04-18
PCT/US2018/027005 WO2018194885A1 (en) 2017-04-18 2018-04-11 Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl compounds

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JP2021517555A JP2021517555A (ja) 2021-07-26
JP7110232B2 true JP7110232B2 (ja) 2022-08-01

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JP2022115300A Active JP7331212B2 (ja) 2017-04-18 2022-07-20 フェニル－２－ヒドロキシ－アセチルアミノ－２－メチル－フェニル化合物

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US (2) US11655214B2 (https=)
EP (2) EP4039675B1 (https=)
JP (2) JP7110232B2 (https=)
KR (2) KR102575246B1 (https=)
CN (2) CN117510405A (https=)
AU (2) AU2018255191B2 (https=)
BR (1) BR112019021867A2 (https=)
CO (1) CO2019012767A2 (https=)
CR (1) CR20190519A (https=)
CY (1) CY1125150T1 (https=)
DK (2) DK4039675T3 (https=)
ES (2) ES2988739T3 (https=)
FI (1) FI4039675T3 (https=)
HR (2) HRP20220263T1 (https=)
HU (2) HUE057745T2 (https=)
IL (2) IL270005B (https=)
LT (2) LT3612519T (https=)
MX (2) MX389724B (https=)
MY (1) MY199442A (https=)
NZ (1) NZ758291A (https=)
PH (1) PH12019502363B1 (https=)
PL (2) PL4039675T3 (https=)
PT (2) PT4039675T (https=)
RS (2) RS65914B1 (https=)
SA (1) SA519410320B1 (https=)
SG (1) SG11201909680UA (https=)
SI (2) SI4039675T1 (https=)
SM (2) SMT202400357T1 (https=)
WO (1) WO2018194885A1 (https=)
ZA (1) ZA201906811B (https=)

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PL4039675T3 (pl) 2017-04-18 2025-01-07 Eli Lilly And Company Związki fenylo-2-hydroksyacetyloamino-2-metylo-fenylowe
US20210121527A1 (en) * 2018-03-26 2021-04-29 Icahn School Of Medicine At Mount Sinai Methods of treating minimal residual cancer
EP4021893A1 (en) * 2019-08-29 2022-07-06 Hibercell, Inc. Perk inhibiting compounds
US20220356186A1 (en) * 2019-08-29 2022-11-10 Hibercell, Inc. Perk inhibiting pyrrolopyrimidine compounds
WO2021041976A1 (en) 2019-08-29 2021-03-04 Hibercell, Inc. Perk inhibiting indolinyl compounds
US12331054B2 (en) 2019-08-29 2025-06-17 Hibercell, Inc. Perk inhibiting imidazolopyrazine compounds
WO2021231788A1 (en) * 2020-05-13 2021-11-18 Hibercell, Inc. Perk inhibiting pyrrolopyrimidine compounds to treat viral infections
WO2021231782A1 (en) * 2020-05-13 2021-11-18 Hibercell, Inc. Perk inhibitors for treating viral infections
CN113234029B (zh) * 2021-05-25 2022-03-22 白银康寓信生物科技有限公司 一种2-氨基-3,5-二卤代吡嗪的合成方法
AU2024242199A1 (en) * 2023-03-30 2025-10-30 Hibercell, Inc. Crystalline forms of (r)-2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)-n-isopropylnicotinamide and methods for using the same
GB202407386D0 (en) 2024-05-24 2024-07-10 Apollo Ap45 Ltd 1H-pyrazolo(4,3-D)pyrimidine derivatives

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JP2005530760A (ja) 2002-05-03 2005-10-13 エクセリクシス， インク． プロテインキナーゼモジュレーターおよびその使用方法
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WO2017019442A1 (en) 2015-07-24 2017-02-02 Blueprint Medicines Corporation Compounds useful for treating disorders related to kit and pdgfr

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SMT202400357T1 (it) 2024-11-15
JP2021517555A (ja) 2021-07-26
US20230373922A1 (en) 2023-11-23
HRP20220263T1 (hr) 2022-04-29
KR20190140966A (ko) 2019-12-20
RS62933B1 (sr) 2022-03-31
CN110831927A (zh) 2020-02-21
EP3612519A1 (en) 2020-02-26
US11655214B2 (en) 2023-05-23
SA519410320B1 (ar) 2022-05-08
KR20230129627A (ko) 2023-09-08
EP3612519B1 (en) 2021-12-01
PL4039675T3 (pl) 2025-01-07
CY1125150T1 (el) 2023-06-09
MX2022001310A (es) 2022-03-02
CN110831927B (zh) 2023-07-14
LT3612519T (lt) 2022-03-25
SMT202200100T1 (it) 2022-03-21
EP4039675B1 (en) 2024-06-12
MY199442A (en) 2023-10-28
ES2906847T3 (es) 2022-04-20
RU2019136694A (ru) 2021-05-18
AU2022206702A1 (en) 2022-08-11
SG11201909680UA (en) 2019-11-28
US12590064B2 (en) 2026-03-31
HRP20241188T1 (hr) 2024-12-06
CO2019012767A2 (es) 2020-04-01
PT3612519T (pt) 2022-02-22
AU2022206702B2 (en) 2024-04-11
WO2018194885A1 (en) 2018-10-25
MX389724B (es) 2025-03-20
AU2018255191B2 (en) 2022-04-21
AU2018255191A1 (en) 2019-11-07
PH12019502363A1 (en) 2020-12-07
JP7331212B2 (ja) 2023-08-22
RS65914B1 (sr) 2024-10-31
PT4039675T (pt) 2024-09-16
NZ758291A (en) 2025-11-28
DK3612519T3 (da) 2022-03-07
SI3612519T1 (sl) 2022-04-29
FI4039675T3 (fi) 2024-09-10
DK4039675T3 (da) 2024-09-02
EP4039675A1 (en) 2022-08-10
CA3060564A1 (en) 2018-10-25
MX2019012428A (es) 2022-01-28
CR20190519A (es) 2020-03-06
BR112019021867A2 (pt) 2020-05-26
HUE068023T2 (hu) 2024-12-28
IL288822B2 (en) 2023-06-01
IL288822A (en) 2022-02-01
ES2988739T3 (es) 2024-11-21
HUE057745T2 (hu) 2022-06-28
US20210114985A1 (en) 2021-04-22
CN117510405A (zh) 2024-02-06
PL3612519T3 (pl) 2022-05-02
RU2019136694A3 (https=) 2021-05-19
ZA201906811B (en) 2021-01-27
LT4039675T (lt) 2024-10-10
JP2022141835A (ja) 2022-09-29
KR102575246B1 (ko) 2023-09-06
PH12019502363B1 (en) 2023-11-15
IL270005B (en) 2022-01-01
SI4039675T1 (sl) 2024-10-30

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