JP7105797B2 - 化合物及びその使用方法 - Google Patents

化合物及びその使用方法 Download PDF

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Publication number
JP7105797B2
JP7105797B2 JP2019548536A JP2019548536A JP7105797B2 JP 7105797 B2 JP7105797 B2 JP 7105797B2 JP 2019548536 A JP2019548536 A JP 2019548536A JP 2019548536 A JP2019548536 A JP 2019548536A JP 7105797 B2 JP7105797 B2 JP 7105797B2
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alkyl
carbocyclyl
optionally substituted
cyano
halo
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JP2019535838A5 (enExample
JP2019535838A (ja
Inventor
キラン レディ，
ボテッラ， ガブリエル マルティネス
アンドリュー マーク グリフィン，
ブライアン エドワード マロン，
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プラクシス プレシジョン メディシンズ， インコーポレイテッド
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Publication of JP2019535838A publication Critical patent/JP2019535838A/ja
Publication of JP2019535838A5 publication Critical patent/JP2019535838A5/ja
Priority to JP2022111844A priority Critical patent/JP7495962B2/ja
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Priority to JP2024084718A priority patent/JP7801794B2/ja
Priority to JP2025279047A priority patent/JP2026062794A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2019548536A 2016-11-28 2017-11-28 化合物及びその使用方法 Active JP7105797B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2022111844A JP7495962B2 (ja) 2016-11-28 2022-07-12 化合物及びその使用方法
JP2024084718A JP7801794B2 (ja) 2016-11-28 2024-05-24 化合物及びその使用方法
JP2025279047A JP2026062794A (ja) 2016-11-28 2025-12-23 化合物及びその使用方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662427044P 2016-11-28 2016-11-28
US62/427,044 2016-11-28
US201762458306P 2017-02-13 2017-02-13
US62/458,306 2017-02-13
US201762552073P 2017-08-30 2017-08-30
US62/552,073 2017-08-30
PCT/US2017/063533 WO2018098499A1 (en) 2016-11-28 2017-11-28 Compounds and their methods of use

Related Child Applications (1)

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JP2022111844A Division JP7495962B2 (ja) 2016-11-28 2022-07-12 化合物及びその使用方法

Publications (3)

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JP2019535838A JP2019535838A (ja) 2019-12-12
JP2019535838A5 JP2019535838A5 (enExample) 2021-01-07
JP7105797B2 true JP7105797B2 (ja) 2022-07-25

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JP2019548536A Active JP7105797B2 (ja) 2016-11-28 2017-11-28 化合物及びその使用方法
JP2022111844A Active JP7495962B2 (ja) 2016-11-28 2022-07-12 化合物及びその使用方法
JP2024084718A Active JP7801794B2 (ja) 2016-11-28 2024-05-24 化合物及びその使用方法
JP2025279047A Pending JP2026062794A (ja) 2016-11-28 2025-12-23 化合物及びその使用方法

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JP2024084718A Active JP7801794B2 (ja) 2016-11-28 2024-05-24 化合物及びその使用方法
JP2025279047A Pending JP2026062794A (ja) 2016-11-28 2025-12-23 化合物及びその使用方法

Country Status (14)

Country Link
US (3) US11629146B2 (enExample)
EP (2) EP4397308A3 (enExample)
JP (4) JP7105797B2 (enExample)
CN (2) CN110337295B (enExample)
AU (3) AU2017364901A1 (enExample)
BR (1) BR112019010880A2 (enExample)
CA (2) CA3281817A1 (enExample)
DK (1) DK3548033T3 (enExample)
ES (1) ES2992063T3 (enExample)
FI (1) FI3548033T3 (enExample)
HU (1) HUE068842T2 (enExample)
PL (1) PL3548033T3 (enExample)
PT (1) PT3548033T (enExample)
WO (1) WO2018098499A1 (enExample)

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US11773099B2 (en) 2019-05-28 2023-10-03 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11279700B2 (en) 2019-05-31 2022-03-22 Praxis Precision Medicines, Inc. Ion channel modulators
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WO2021039961A1 (ja) * 2019-08-30 2021-03-04 大日本住友製薬株式会社 縮環ピラゾール誘導体
JP2023503343A (ja) 2019-11-26 2023-01-27 プラクシス プレシジョン メディシンズ， インコーポレイテッド イオンチャネルモジュレーター
US11767325B2 (en) 2019-11-26 2023-09-26 Praxis Precision Medicines, Inc. Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators
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KR20250005348A (ko) 2022-04-26 2025-01-09 프락시스 프리시젼 메디신즈, 인크. 신경 장애의 치료
WO2024077273A2 (en) * 2022-10-07 2024-04-11 Denali Therapeutics Inc. Compounds, compositions, and methods
WO2026082004A1 (zh) * 2024-10-14 2026-04-23 上海京新生物医药有限公司 稠合杂芳基衍生物及其制备方法与应用
CN119613413B (zh) * 2024-12-26 2026-02-06 上海皓元医药股份有限公司 一种非唑奈坦的制备方法

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JP2023144130A (ja) * 2018-05-30 2023-10-06 プラクシス プレシジョン メディシンズ， インコーポレイテッド イオンチャネルモジュレーター
JP7359847B2 (ja) 2018-05-30 2023-10-11 プラクシス プレシジョン メディシンズ， インコーポレイテッド イオンチャネルモジュレーター
JP7603118B2 (ja) 2018-05-30 2024-12-19 プラクシス プレシジョン メディシンズ， インコーポレイテッド イオンチャネルモジュレーター

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