AU2017364901A1 - Compounds and their methods of use - Google Patents

Info

Publication number

AU2017364901A1

AU2017364901A1 AU2017364901A AU2017364901A AU2017364901A1 AU 2017364901 A1 AU2017364901 A1 AU 2017364901A1 AU 2017364901 A AU2017364901 A AU 2017364901A AU 2017364901 A AU2017364901 A AU 2017364901A AU 2017364901 A1 AU2017364901 A1 AU 2017364901A1

Authority

AU

Australia

Prior art keywords

alkyl

optionally substituted

carbocyclyl

mixture

compound

Prior art date

2016-11-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

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• 238000000034 method Methods 0.000 title claims abstract description 128
• 150000001875 compounds Chemical class 0.000 title claims description 155
• 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 118
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• 208000036572 Myoclonic epilepsy Diseases 0.000 claims abstract description 10
• 206010073677 Severe myoclonic epilepsy of infancy Diseases 0.000 claims abstract description 10
• 125000000217 alkyl group Chemical group 0.000 claims description 325
• 125000000623 heterocyclic group Chemical group 0.000 claims description 231
• 125000005843 halogen group Chemical group 0.000 claims description 198
• 125000004452 carbocyclyl group Chemical group 0.000 claims description 177
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 175
• 229910052739 hydrogen Inorganic materials 0.000 claims description 148
• 239000001257 hydrogen Substances 0.000 claims description 148
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 146
• 125000003118 aryl group Chemical group 0.000 claims description 126
• 229910052736 halogen Inorganic materials 0.000 claims description 122
• 150000002367 halogens Chemical class 0.000 claims description 90
• -1 -ORb Chemical group 0.000 claims description 76
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 75
• 150000003839 salts Chemical class 0.000 claims description 68
• 125000003342 alkenyl group Chemical group 0.000 claims description 44
• 125000000304 alkynyl group Chemical group 0.000 claims description 40
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 37
• 229910052757 nitrogen Inorganic materials 0.000 claims description 26
• 208000014644 Brain disease Diseases 0.000 claims description 25
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• 229910052799 carbon Inorganic materials 0.000 claims description 25
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• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 17
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• 125000000547 substituted alkyl group Chemical group 0.000 claims description 9
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