JP7101354B2 - 上部消化管内菌叢改善剤 - Google Patents
上部消化管内菌叢改善剤 Download PDFInfo
- Publication number
- JP7101354B2 JP7101354B2 JP2018523986A JP2018523986A JP7101354B2 JP 7101354 B2 JP7101354 B2 JP 7101354B2 JP 2018523986 A JP2018523986 A JP 2018523986A JP 2018523986 A JP2018523986 A JP 2018523986A JP 7101354 B2 JP7101354 B2 JP 7101354B2
- Authority
- JP
- Japan
- Prior art keywords
- upper gastrointestinal
- lactic acid
- improving agent
- present
- flora
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000002496 gastric effect Effects 0.000 title claims description 74
- 210000002438 upper gastrointestinal tract Anatomy 0.000 claims description 32
- 241000186606 Lactobacillus gasseri Species 0.000 claims description 24
- 241000186000 Bifidobacterium Species 0.000 claims description 22
- 230000000694 effects Effects 0.000 claims description 22
- 241000590002 Helicobacter pylori Species 0.000 claims description 21
- 229940037467 helicobacter pylori Drugs 0.000 claims description 21
- 230000037406 food intake Effects 0.000 claims description 16
- 239000004480 active ingredient Substances 0.000 claims description 11
- 230000001580 bacterial effect Effects 0.000 claims description 7
- 230000006872 improvement Effects 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 114
- 241000894006 Bacteria Species 0.000 description 71
- 235000014655 lactic acid Nutrition 0.000 description 57
- 239000004310 lactic acid Substances 0.000 description 57
- 239000003795 chemical substances by application Substances 0.000 description 50
- 208000018522 Gastrointestinal disease Diseases 0.000 description 32
- 210000002784 stomach Anatomy 0.000 description 17
- 241000605861 Prevotella Species 0.000 description 16
- 239000012530 fluid Substances 0.000 description 14
- 238000000034 method Methods 0.000 description 14
- 201000010099 disease Diseases 0.000 description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 13
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- 239000000306 component Substances 0.000 description 9
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- 210000004080 milk Anatomy 0.000 description 8
- 235000013618 yogurt Nutrition 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- 241000186660 Lactobacillus Species 0.000 description 6
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- 230000036541 health Effects 0.000 description 5
- 206010000060 Abdominal distension Diseases 0.000 description 4
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- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
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- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
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- 239000013589 supplement Substances 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 108020000946 Bacterial DNA Proteins 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 241000186016 Bifidobacterium bifidum Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 238000007399 DNA isolation Methods 0.000 description 1
- 238000012327 Endoscopic diagnosis Methods 0.000 description 1
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- 241000589989 Helicobacter Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
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- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241001430183 Veillonellaceae Species 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 230000009471 action Effects 0.000 description 1
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- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
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- 229940002008 bifidobacterium bifidum Drugs 0.000 description 1
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- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 235000019543 dairy drink Nutrition 0.000 description 1
- 235000021185 dessert Nutrition 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
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- 235000006694 eating habits Nutrition 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 235000013861 fat-free Nutrition 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000021107 fermented food Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000001630 jejunum Anatomy 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012533 medium component Substances 0.000 description 1
- 235000021243 milk fat Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000007659 motor function Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
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- 239000002773 nucleotide Substances 0.000 description 1
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- 229920001778 nylon Polymers 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
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- 239000000123 paper Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 235000021110 pickles Nutrition 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000008476 powdered milk Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
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- 208000011580 syndromic disease Diseases 0.000 description 1
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- 231100000397 ulcer Toxicity 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
- A61K2035/115—Probiotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016122155 | 2016-06-20 | ||
| JP2016122155 | 2016-06-20 | ||
| PCT/JP2017/022065 WO2017221799A1 (fr) | 2016-06-20 | 2017-06-15 | Agent améliorant la flore gastro-intestinale supérieure. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2017221799A1 JPWO2017221799A1 (ja) | 2019-04-11 |
| JP7101354B2 true JP7101354B2 (ja) | 2022-07-15 |
Family
ID=60783487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018523986A Active JP7101354B2 (ja) | 2016-06-20 | 2017-06-15 | 上部消化管内菌叢改善剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20190151381A1 (fr) |
| JP (1) | JP7101354B2 (fr) |
| CN (1) | CN109310718B (fr) |
| SG (1) | SG11201810492QA (fr) |
| WO (1) | WO2017221799A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2018124003A1 (ja) * | 2016-12-27 | 2019-11-21 | 株式会社明治 | 胃内菌叢の占有率測定による機能性消化管障害の検出方法及び胃内菌叢改善剤 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5300772B2 (ja) | 2010-03-26 | 2013-09-25 | 森永乳業株式会社 | 新規乳酸菌、並びに新規乳酸菌を含有する医薬、飲食品、及び飼料 |
| WO2014077365A1 (fr) | 2012-11-16 | 2014-05-22 | カルピス株式会社 | Agent soulageant les troubles intestinaux induits par le stress comprenant une souche spécifique de lactobacillus gasseri ou produit de traitement associé |
| JP2014518897A (ja) | 2011-06-08 | 2014-08-07 | オルガノバランス ゲーエムベーハー | 噴霧乾燥ラクトバチルス株／細胞およびヘリコバクターピロリに対するその使用 |
| WO2015129281A1 (fr) | 2014-02-28 | 2015-09-03 | 株式会社明治 | Agent prophylactique et/ou thérapeutique pour troubles gastro-intestinaux fonctionnels |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3046303B1 (ja) * | 1999-06-24 | 2000-05-29 | 明治乳業株式会社 | Ｈｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉ除菌性飲食品 |
| CN101522887B (zh) * | 2007-02-13 | 2012-07-11 | 森永乳业株式会社 | 新型乳酸菌 |
-
2017
- 2017-06-15 SG SG11201810492QA patent/SG11201810492QA/en unknown
- 2017-06-15 CN CN201780038418.3A patent/CN109310718B/zh active Active
- 2017-06-15 WO PCT/JP2017/022065 patent/WO2017221799A1/fr active Application Filing
- 2017-06-15 JP JP2018523986A patent/JP7101354B2/ja active Active
- 2017-06-15 US US16/308,526 patent/US20190151381A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5300772B2 (ja) | 2010-03-26 | 2013-09-25 | 森永乳業株式会社 | 新規乳酸菌、並びに新規乳酸菌を含有する医薬、飲食品、及び飼料 |
| JP2014518897A (ja) | 2011-06-08 | 2014-08-07 | オルガノバランス ゲーエムベーハー | 噴霧乾燥ラクトバチルス株／細胞およびヘリコバクターピロリに対するその使用 |
| WO2014077365A1 (fr) | 2012-11-16 | 2014-05-22 | カルピス株式会社 | Agent soulageant les troubles intestinaux induits par le stress comprenant une souche spécifique de lactobacillus gasseri ou produit de traitement associé |
| WO2015129281A1 (fr) | 2014-02-28 | 2015-09-03 | 株式会社明治 | Agent prophylactique et/ou thérapeutique pour troubles gastro-intestinaux fonctionnels |
Non-Patent Citations (5)
| Title |
|---|
| Helicobacter Res., 2002, Vol.6 No.2, p.101-105 |
| J Dairy Sci., 2015, Vol.98, p.8107-8120 |
| Nature, 2012, Vol.486, p.207-214 |
| 日本小児栄養消化器肝臓学会雑誌, 2008, Vol.22 No.1, p.44(II-1) |
| 日本臨床内科医会会誌, 2003, Vol.18 No.1, p.36-39 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2017221799A1 (ja) | 2019-04-11 |
| CN109310718A (zh) | 2019-02-05 |
| WO2017221799A1 (fr) | 2017-12-28 |
| US20190151381A1 (en) | 2019-05-23 |
| SG11201810492QA (en) | 2019-01-30 |
| CN109310718B (zh) | 2022-06-17 |
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