JP7096817B2 - 三環式複素環式誘導体及びその使用 - Google Patents
三環式複素環式誘導体及びその使用 Download PDFInfo
- Publication number
- JP7096817B2 JP7096817B2 JP2019523810A JP2019523810A JP7096817B2 JP 7096817 B2 JP7096817 B2 JP 7096817B2 JP 2019523810 A JP2019523810 A JP 2019523810A JP 2019523810 A JP2019523810 A JP 2019523810A JP 7096817 B2 JP7096817 B2 JP 7096817B2
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- Japan
- Prior art keywords
- xanthene
- methyl
- oxy
- alkylene
- ethoxy
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
- C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
- C07D311/86—Oxygen atoms, e.g. xanthones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
- C07D335/12—Thioxanthenes
- C07D335/14—Thioxanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
- C07D335/16—Oxygen atoms, e.g. thioxanthones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
- C07D335/12—Thioxanthenes
- C07D335/14—Thioxanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
- C07D335/18—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ72576716 | 2016-11-04 | ||
| NZ725767 | 2016-11-04 | ||
| PCT/IB2017/056848 WO2018083635A2 (en) | 2016-11-04 | 2017-11-03 | Tricyclic heterocyclic derivatives and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019537602A JP2019537602A (ja) | 2019-12-26 |
| JP2019537602A5 JP2019537602A5 (enExample) | 2020-12-10 |
| JP7096817B2 true JP7096817B2 (ja) | 2022-07-06 |
Family
ID=62075593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523810A Active JP7096817B2 (ja) | 2016-11-04 | 2017-11-03 | 三環式複素環式誘導体及びその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11028064B2 (enExample) |
| EP (1) | EP3535243B1 (enExample) |
| JP (1) | JP7096817B2 (enExample) |
| CN (1) | CN110139852A (enExample) |
| AU (1) | AU2017355603A1 (enExample) |
| WO (1) | WO2018083635A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102240821B1 (ko) * | 2017-03-13 | 2021-04-15 | 광주과학기술원 | P2x1 및 p2x3 수용체 길항제로 사용되는 신규한 5-히드록시 피리딘계 화합물 및 이를 포함하는 약학적 조성물 |
| CN108976164A (zh) * | 2018-06-20 | 2018-12-11 | 南通常佑药业科技有限公司 | 手性哌啶胺化合物的制备方法及手性拆分剂的回收套用方法 |
| WO2021101521A1 (en) * | 2019-11-19 | 2021-05-27 | Provecetus Pharmatech, Inc. | Composition and method for treating hematologic cancers |
| BR112023004719A2 (pt) * | 2020-09-21 | 2023-04-18 | Hutchison Medipharma Ltd | Compostos heteroaromáticos e usos dos mesmos |
| CN114890899B (zh) * | 2022-04-02 | 2023-10-03 | 南京农业大学 | 一种制备二苯醚酯类化合物的方法 |
| CN115557890B (zh) * | 2022-09-01 | 2024-06-25 | 宁波大学 | 一种多取代吖啶酮烷基衍生物及其制备方法和用途 |
| IT202200024963A1 (it) * | 2022-12-05 | 2024-06-05 | Angelini Pharma S P A | Composti attivatori dei canali potassio Kv7.2/Kv7.3 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010506948A (ja) | 2006-10-20 | 2010-03-04 | アイアールエム・リミテッド・ライアビリティ・カンパニー | C−kitおよびpdgfr受容体を調節するための組成物および方法 |
| WO2013161816A1 (ja) | 2012-04-23 | 2013-10-31 | 田辺三菱製薬株式会社 | アミン化合物及びその医薬用途 |
| WO2016040858A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1192651A (en) * | 1968-01-09 | 1970-05-20 | Sterling Drug Inc | Xanthene Derivatives |
| BE759292A (fr) | 1969-11-27 | 1971-05-24 | Allen & Hanburys Ltd | Derives de xanthone, leur preparation et leur emploi |
| US3859286A (en) * | 1970-12-11 | 1975-01-07 | Richardson Merrell Inc | Bis-basic ketones of xanthene and xanthen-9-one |
| EP0278176B1 (en) | 1986-12-23 | 1994-03-09 | Warner-Lambert Company | Compounds having antitumour and antibacterial properties |
| AU2002367773A1 (en) | 2001-04-06 | 2003-11-03 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
| JP4654035B2 (ja) | 2002-11-05 | 2011-03-16 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 抗菌剤 |
| WO2005003131A1 (en) | 2003-06-27 | 2005-01-13 | Janssen Pharmaceutica N.V. | Tricyclic delta opioid modulators |
| AU2005335481A1 (en) | 2004-08-05 | 2007-04-19 | Janssen Pharmaceutica N.V. | Tricyclic delta- opioid modulators |
| WO2006044707A1 (en) | 2004-10-13 | 2006-04-27 | Smithkline Beecham Corporation | Chemical compounds |
| PE20080359A1 (es) | 2006-04-19 | 2008-06-06 | Novartis Ag | Compuestos de benzoxazol y benzotiazol 6-0-sustituidos y metodos de inhibicion de la senalizacion de csf-1r |
| WO2008016661A2 (en) * | 2006-08-02 | 2008-02-07 | Xanthus Pharmaceuticals, Inc. | Morpholino compounds for treating inflammatory and demyelinating diseases and cancers |
| WO2008048117A2 (en) | 2006-10-17 | 2008-04-24 | Auckland Uniservices Limited | Synthesis of 5,6-dimethyl-9-oxo-9h-xanthen-4-yl- acetic acid (dmxaa) |
| CN101195609B (zh) | 2007-09-28 | 2011-04-20 | 武汉远大制药集团有限公司 | 5,6-二甲基呫吨酮-4-乙酸的制备方法及由此方法制备的衍生物和药物制剂 |
| DE102007047495B4 (de) | 2007-10-04 | 2009-07-16 | Contitech Kühner Gmbh & Cie. Kg | Wellrohrschlauchleitung sowie Verfahren zu deren Herstellung |
| CA2932121A1 (en) | 2007-11-30 | 2009-06-11 | Newlink Genetics Corporation | Ido inhibitors |
| CN101279967B (zh) | 2008-05-29 | 2010-11-10 | 武汉远大制药集团有限公司 | 一种治疗癌症的三甲基呫吨酮-4-乙酸药物组合物及其用途 |
| AR072295A1 (es) | 2008-06-26 | 2010-08-18 | Novartis Ag | Metodo de preparacion del acio 5,6-dimetil-9-oxo-9h-xanten-4-il-acetico |
| US20110201678A1 (en) | 2008-10-17 | 2011-08-18 | Masse Craig E | Xanthenone-4-Acetic Acid Derivatives |
| AU2010295622A1 (en) * | 2009-09-16 | 2012-05-10 | Cylene Pharmaceuticals, Inc. | Tricyclic compounds and pharmaceutical uses thereof |
| US8722720B2 (en) | 2009-10-28 | 2014-05-13 | Newlink Genetics Corporation | Imidazole derivatives as IDO inhibitors |
| UA108222C2 (xx) | 2009-12-21 | 2015-04-10 | СПОЛУКИ ЗАМІЩЕНОГО N-(1H-ІНДАЗОЛ-4-ІЛ)ІМІДАЗОЛ$1,2-а]ПІРИДИН-3-КАРБОКСАМІДУ ЯК ІНГІБІТОРИ cFMS | |
| TWI414520B (zh) | 2010-10-06 | 2013-11-11 | Nat Defense Medical Ct | 噻噸酮衍生物 |
| PH12013501221A1 (en) | 2010-12-13 | 2022-03-30 | Array Biopharma Inc | SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS |
| NO2694640T3 (enExample) | 2011-04-15 | 2018-03-17 | ||
| EP2791143B1 (en) | 2011-12-15 | 2016-02-24 | Bayer Intellectual Property GmbH | Substituted benzothienyl-pyrrolotriazines and uses thereof in the treatment of cancer |
| GB2498976A (en) | 2012-02-01 | 2013-08-07 | Prosidion Ltd | GPR119 agonists useful in the treatment of type II diabetes |
| AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
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2017
- 2017-11-03 JP JP2019523810A patent/JP7096817B2/ja active Active
- 2017-11-03 WO PCT/IB2017/056848 patent/WO2018083635A2/en not_active Ceased
- 2017-11-03 US US16/347,420 patent/US11028064B2/en active Active
- 2017-11-03 CN CN201780082274.1A patent/CN110139852A/zh active Pending
- 2017-11-03 AU AU2017355603A patent/AU2017355603A1/en not_active Abandoned
- 2017-11-03 EP EP17867398.4A patent/EP3535243B1/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010506948A (ja) | 2006-10-20 | 2010-03-04 | アイアールエム・リミテッド・ライアビリティ・カンパニー | C−kitおよびpdgfr受容体を調節するための組成物および方法 |
| WO2013161816A1 (ja) | 2012-04-23 | 2013-10-31 | 田辺三菱製薬株式会社 | アミン化合物及びその医薬用途 |
| WO2016040858A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3535243A4 (en) | 2020-05-06 |
| JP2019537602A (ja) | 2019-12-26 |
| EP3535243B1 (en) | 2021-12-15 |
| WO2018083635A2 (en) | 2018-05-11 |
| AU2017355603A1 (en) | 2019-06-20 |
| EP3535243A2 (en) | 2019-09-11 |
| US11028064B2 (en) | 2021-06-08 |
| WO2018083635A3 (en) | 2018-07-26 |
| CN110139852A (zh) | 2019-08-16 |
| US20190276423A1 (en) | 2019-09-12 |
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