JP7091255B2 - Ｇｌｐ－１受容体リガンド部分コンジュゲート化オリゴヌクレオチドおよびその使用 - Google Patents

Ｇｌｐ－１受容体リガンド部分コンジュゲート化オリゴヌクレオチドおよびその使用 Download PDF

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JP7091255B2
JP7091255B2 JP2018557878A JP2018557878A JP7091255B2 JP 7091255 B2 JP7091255 B2 JP 7091255B2 JP 2018557878 A JP2018557878 A JP 2018557878A JP 2018557878 A JP2018557878 A JP 2018557878A JP 7091255 B2 JP7091255 B2 JP 7091255B2
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certain embodiments
glp
oligonucleotide
ser
glu
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JP2019516686A (ja
JP2019516686A5 (enExample
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ブレット・ピー・モニア
タザ・ピー・プラカシュ
ガース・エイ・キンバーガー
リチャード・リー
プニト・ピー・セス
シャリニ・アンデション
エヴァ・カリーナ・アンマラ
ダニエル・ローラン・クネール
アストリッド・マリア・エルヴェゴード－ハルヴァーション
ウィリアム・ドゥルーリー
エリック・ヴァルール
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AstraZeneca AB
Ionis Pharmaceuticals Inc
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AstraZeneca AB
Ionis Pharmaceuticals Inc
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JP2018557878A 2016-05-06 2017-05-04 Ｇｌｐ－１受容体リガンド部分コンジュゲート化オリゴヌクレオチドおよびその使用 Active JP7091255B2 (ja)

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JP2022062810A JP7498740B2 (ja) 2016-05-06 2022-04-05 Ｇｌｐ－１受容体リガンド部分コンジュゲート化オリゴヌクレオチドおよびその使用

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US201662333080P 2016-05-06 2016-05-06
US62/333,080 2016-05-06
PCT/US2017/031010 WO2017192820A1 (en) 2016-05-06 2017-05-04 Glp-1 receptor ligand moiety conjugated oligonucleotides and uses thereof

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KR102608220B1 (ko) 2016-05-06 2023-11-29 아이오니스 파마수티컬즈, 인코포레이티드 Glp-1 수용체 리간드 모이어티 컨쥬게이트된 올리고뉴클레오티드 및 이의 용도
US11359200B2 (en) * 2017-04-09 2022-06-14 The Cleveland Clinic Foundation Cancer treatment by MALAT1 inhibition
WO2018202870A1 (en) 2017-05-04 2018-11-08 Follicum Ab Peptides for treatment of diabetes
CN119876131A (zh) * 2017-11-08 2025-04-25 Ionis制药公司 Glp-1受体配体部分缀合的寡核苷酸及其用途
CN107881187A (zh) * 2017-11-20 2018-04-06 珠海联邦制药股份有限公司 将大肠杆菌表达的融合蛋白转化为利拉鲁肽的制备方法及应用
KR20210134686A (ko) * 2019-02-27 2021-11-10 아이오니스 파마수티컬즈, 인코포레이티드 Malat1 발현의 조절인자
KR102193211B1 (ko) * 2019-11-27 2020-12-18 (주)디앤디파마텍 비오틴 모이어티가 결합된 폴리펩티드 및 이를 포함하는 경구 투여용 약학적 조성물
US12122817B2 (en) * 2020-09-22 2024-10-22 Serpentide Inc. Long-lasting GLP1 analogue drug for type-2 diabetes

Citations (3)

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JP2014524908A (ja) 2011-06-22 2014-09-25 インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション グルカゴン／ｇｌｐ−１レセプターコアゴニスト
JP2014525901A (ja) 2011-06-22 2014-10-02 インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション グルカゴン／ｇｌｐ−１レセプタコ−アゴニスト
WO2014203518A1 (en) 2013-06-16 2014-12-24 National University Corporation Tokyo Medical And Dental University Double-stranded antisense nucleic acid with exon-skipping effect

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