JP7085994B2 - 線維症疾患の治療及び/又は予防用アミノナフトキノン化合物 - Google Patents
線維症疾患の治療及び/又は予防用アミノナフトキノン化合物 Download PDFInfo
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- JP7085994B2 JP7085994B2 JP2018525670A JP2018525670A JP7085994B2 JP 7085994 B2 JP7085994 B2 JP 7085994B2 JP 2018525670 A JP2018525670 A JP 2018525670A JP 2018525670 A JP2018525670 A JP 2018525670A JP 7085994 B2 JP7085994 B2 JP 7085994B2
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022092059A JP7667764B2 (ja) | 2015-11-17 | 2022-06-07 | 線維症疾患の治療及び/又は予防用アミノナフトキノン化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562256516P | 2015-11-17 | 2015-11-17 | |
| US62/256,516 | 2015-11-17 | ||
| PCT/US2016/062568 WO2017087695A1 (en) | 2015-11-17 | 2016-11-17 | Aminonaphthoquinone compounds for treatment and/or prevention of fibrosis diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022092059A Division JP7667764B2 (ja) | 2015-11-17 | 2022-06-07 | 線維症疾患の治療及び/又は予防用アミノナフトキノン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501126A JP2019501126A (ja) | 2019-01-17 |
| JP2019501126A5 JP2019501126A5 (enExample) | 2019-12-26 |
| JP7085994B2 true JP7085994B2 (ja) | 2022-06-17 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018525670A Active JP7085994B2 (ja) | 2015-11-17 | 2016-11-17 | 線維症疾患の治療及び/又は予防用アミノナフトキノン化合物 |
| JP2022092059A Active JP7667764B2 (ja) | 2015-11-17 | 2022-06-07 | 線維症疾患の治療及び/又は予防用アミノナフトキノン化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022092059A Active JP7667764B2 (ja) | 2015-11-17 | 2022-06-07 | 線維症疾患の治療及び/又は予防用アミノナフトキノン化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11833122B2 (enExample) |
| EP (1) | EP3377062B1 (enExample) |
| JP (2) | JP7085994B2 (enExample) |
| KR (1) | KR20180096609A (enExample) |
| CN (2) | CN120204220A (enExample) |
| ES (1) | ES2955665T3 (enExample) |
| TW (1) | TWI673049B (enExample) |
| WO (1) | WO2017087695A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019226213A2 (en) | 2018-03-08 | 2019-11-28 | Incyte Corporation | AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| KR20240159339A (ko) * | 2023-04-28 | 2024-11-05 | 한국원자력의학원 | 폐섬유화 예방 또는 치료를 위한 다코미티닙 및 닌테다닙의 병용 요법 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006502998A (ja) | 2002-07-25 | 2006-01-26 | ヒャリテ−ウニヴェルズィテーツメディジン ベルリン | 線維性疾患治療のためのプロテアソーム阻害剤の使用 |
| JP2008522981A (ja) | 2004-12-07 | 2008-07-03 | プロテオリックス, インコーポレイテッド | プロテアソームを阻害するための組成物 |
| US20110201609A1 (en) | 2008-06-30 | 2011-08-18 | H. Lee Moffitt Cancer Center & Research Institute | Proteasome inhibitors for selectively inducing apoptosis in cancer cells |
| JP2018529639A (ja) | 2015-07-23 | 2018-10-11 | タイペイ・メディカル・ユニバーシティTaipei Medical University | アミノナフトキノン化合物、および疾患におけるユビキチン化−プロテアソーム系をブロックするための薬学的組成物 |
| JP2018529643A (ja) | 2015-07-30 | 2018-10-11 | タイペイ・メディカル・ユニバーシティTaipei Medical University | ユビキチン化−プロテアソーム系に関連する化合物および薬学的組成物 |
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| EP2030981B1 (en) | 2004-05-10 | 2014-07-09 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
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| JP2018529643A (ja) | 2015-07-30 | 2018-10-11 | タイペイ・メディカル・ユニバーシティTaipei Medical University | ユビキチン化−プロテアソーム系に関連する化合物および薬学的組成物 |
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| TW201720433A (zh) | 2017-06-16 |
| JP7667764B2 (ja) | 2025-04-23 |
| US20180325845A1 (en) | 2018-11-15 |
| CA3005614A1 (en) | 2017-05-26 |
| CN120204220A (zh) | 2025-06-27 |
| EP3377062C0 (en) | 2023-09-06 |
| WO2017087695A1 (en) | 2017-05-26 |
| US11833122B2 (en) | 2023-12-05 |
| US20240130984A1 (en) | 2024-04-25 |
| EP3377062A1 (en) | 2018-09-26 |
| ES2955665T3 (es) | 2023-12-05 |
| EP3377062B1 (en) | 2023-09-06 |
| US12453708B2 (en) | 2025-10-28 |
| JP2022116328A (ja) | 2022-08-09 |
| TWI673049B (zh) | 2019-10-01 |
| EP3377062A4 (en) | 2019-07-03 |
| JP2019501126A (ja) | 2019-01-17 |
| CN108697697A (zh) | 2018-10-23 |
| KR20180096609A (ko) | 2018-08-29 |
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