JP7084389B2 - Ｄｈｏｄｈの阻害剤として有用な２，４，５－三置換１，２，４－トリアゾロン - Google Patents

Ｄｈｏｄｈの阻害剤として有用な２，４，５－三置換１，２，４－トリアゾロン Download PDF

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JP7084389B2
JP7084389B2 JP2019522859A JP2019522859A JP7084389B2 JP 7084389 B2 JP7084389 B2 JP 7084389B2 JP 2019522859 A JP2019522859 A JP 2019522859A JP 2019522859 A JP2019522859 A JP 2019522859A JP 7084389 B2 JP7084389 B2 JP 7084389B2
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JP2019533694A (ja
JP2019533694A5 (enExample
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シュテファン・ニコラウス・グラートル
デュイ・グエン
クヌート・アイス
ユディット・ギュンター
ティモ・シュテルフェルト
アンドレアス・ヤンツァー
ズヴェン・クリスティアン
トーマス・ミュラー
シェリフ・エル・シェイク
ハン・ジエ・ジョウ
チャンジア・ジャオ
デイヴィッド・ブライアン・サイクス
スティーヴン・ジェームズ・フェラーラ
ケリー・リュウ
ミヒャエル・クレーバー
クラウディア・メルツ
ミヒャエル・ニーフス
マルティーナ・シェーファー
カチャ・ツィマーマン
カール・フリードリッヒ・ニジング
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2019522859A 2016-10-27 2017-10-25 Ｄｈｏｄｈの阻害剤として有用な２，４，５－三置換１，２，４－トリアゾロン Active JP7084389B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2016/103643 2016-10-27
CNPCT/CN2016/103643 2016-10-27
US201762569296P 2017-10-06 2017-10-06
US62/569,296 2017-10-06
PCT/EP2017/077252 WO2018077923A1 (en) 2016-10-27 2017-10-25 2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of dhodh

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JP2019533694A JP2019533694A (ja) 2019-11-21
JP2019533694A5 JP2019533694A5 (enExample) 2020-12-03
JP7084389B2 true JP7084389B2 (ja) 2022-06-14

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US (4) US10815215B2 (enExample)
EP (1) EP3532468B1 (enExample)
JP (1) JP7084389B2 (enExample)
KR (1) KR20190084954A (enExample)
CN (2) CN110023302B (enExample)
AU (1) AU2017351688B2 (enExample)
BR (1) BR112019008458A2 (enExample)
CA (1) CA3041643A1 (enExample)
CL (1) CL2019001160A1 (enExample)
CO (1) CO2019004137A2 (enExample)
CR (1) CR20190212A (enExample)
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DO (1) DOP2019000110A (enExample)
EC (1) ECSP19030002A (enExample)
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JO (1) JOP20190094A1 (enExample)
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NI (1) NI201900041A (enExample)
PE (1) PE20191005A1 (enExample)
PH (1) PH12019500932A1 (enExample)
TN (1) TN2019000136A1 (enExample)
TW (1) TW201827414A (enExample)
UA (1) UA123688C2 (enExample)
UY (1) UY37461A (enExample)
WO (1) WO2018077923A1 (enExample)

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US10968216B2 (en) 2016-10-27 2021-04-06 Bayer Aktiengesellschaft 4,5-annulated 1,2,4-triazolones
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JP2023535346A (ja) * 2020-07-14 2023-08-17 ナンジン ゼンシャイン ファーマシューティカルズ カンパニー リミテッド Ｄｈｏｄｈ阻害剤としての化合物
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WO2022167402A1 (en) 2021-02-02 2022-08-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of therapy comprising administering a therapeutically effective combination comprising a dhodh inhibitor and an idh inhibitor
WO2023280181A1 (zh) * 2021-07-05 2023-01-12 微境生物医药科技(上海)有限公司 用作dhodh抑制剂的1,2,4-三唑酮衍生物及其制备方法和用途
WO2023093812A1 (zh) * 2021-11-26 2023-06-01 南京明德新药研发有限公司 三氮唑酮类化合物的晶型及其应用
KR102686544B1 (ko) * 2023-12-04 2024-07-19 대한민국 Bay-2402234을 유효성분으로 포함하는 중증열성혈소판감소증후군 예방 또는 치료용 약학 조성물
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NI201900041A (es) 2019-06-11
MX2019005009A (es) 2019-08-12
TN2019000136A1 (en) 2020-10-05
CN115557907B (zh) 2024-12-06
PE20191005A1 (es) 2019-07-15
PH12019500932A1 (en) 2020-01-20
EP3532468B1 (en) 2022-03-23
US11130745B2 (en) 2021-09-28
TW201827414A (zh) 2018-08-01
US20230365524A1 (en) 2023-11-16
WO2018077923A1 (en) 2018-05-03
US12486248B2 (en) 2025-12-02
CN110023302A (zh) 2019-07-16
IL266214A (en) 2019-06-30
CU24572B1 (es) 2022-01-13
DOP2019000110A (es) 2019-05-31
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US20200377472A1 (en) 2020-12-03
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JP2019533694A (ja) 2019-11-21
CN115557907A (zh) 2023-01-03
GEP20217248B (en) 2021-04-26
JOP20190094A1 (ar) 2019-04-25
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US20210188805A9 (en) 2021-06-24
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US20220135536A1 (en) 2022-05-05
IL266214B (en) 2021-10-31
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US11713304B2 (en) 2023-08-01
UA123688C2 (uk) 2021-05-12
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CO2019004137A2 (es) 2019-05-10
MX382665B (es) 2025-03-13
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