JP7083214B2 - 膵がんを治療する方法 - Google Patents
膵がんを治療する方法 Download PDFInfo
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- JP7083214B2 JP7083214B2 JP2018565305A JP2018565305A JP7083214B2 JP 7083214 B2 JP7083214 B2 JP 7083214B2 JP 2018565305 A JP2018565305 A JP 2018565305A JP 2018565305 A JP2018565305 A JP 2018565305A JP 7083214 B2 JP7083214 B2 JP 7083214B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662349217P | 2016-06-13 | 2016-06-13 | |
US62/349,217 | 2016-06-13 | ||
US201662382689P | 2016-09-01 | 2016-09-01 | |
US62/382,689 | 2016-09-01 | ||
PCT/US2017/037264 WO2017218544A1 (en) | 2016-06-13 | 2017-06-13 | Methods of treating pancreatic cancer |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020103107A Division JP2020147602A (ja) | 2016-06-13 | 2020-06-15 | 膵がんを治療する方法 |
JP2020103105A Division JP2020147601A (ja) | 2016-06-13 | 2020-06-15 | 膵がんを治療する方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2019518038A JP2019518038A (ja) | 2019-06-27 |
JP2019518038A5 JP2019518038A5 (zh) | 2020-07-27 |
JP7083214B2 true JP7083214B2 (ja) | 2022-06-10 |
Family
ID=60663739
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018565305A Active JP7083214B2 (ja) | 2016-06-13 | 2017-06-13 | 膵がんを治療する方法 |
JP2020103105A Withdrawn JP2020147601A (ja) | 2016-06-13 | 2020-06-15 | 膵がんを治療する方法 |
JP2020103107A Withdrawn JP2020147602A (ja) | 2016-06-13 | 2020-06-15 | 膵がんを治療する方法 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020103105A Withdrawn JP2020147601A (ja) | 2016-06-13 | 2020-06-15 | 膵がんを治療する方法 |
JP2020103107A Withdrawn JP2020147602A (ja) | 2016-06-13 | 2020-06-15 | 膵がんを治療する方法 |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP3468548B1 (zh) |
JP (3) | JP7083214B2 (zh) |
KR (2) | KR20190017913A (zh) |
CN (1) | CN109562086A (zh) |
AU (1) | AU2017283491B2 (zh) |
BR (1) | BR112018075660A2 (zh) |
CA (1) | CA3026515A1 (zh) |
ES (1) | ES2895749T3 (zh) |
IL (1) | IL263508B2 (zh) |
MX (1) | MX2018015172A (zh) |
RU (1) | RU2768479C2 (zh) |
SG (2) | SG11201810940XA (zh) |
WO (1) | WO2017218544A1 (zh) |
ZA (1) | ZA201808258B (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10195188B2 (en) | 2016-06-13 | 2019-02-05 | Chemocentryx, Inc. | Method of treating pancreatic cancer |
BR112018075660A2 (pt) * | 2016-06-13 | 2019-04-09 | Chemocentryx, Inc. | métodos de tratamento de câncer de pâncreas |
CN112714648B (zh) * | 2018-09-19 | 2024-05-14 | 奥托泰利克生物公司 | 抗癌用组合物 |
WO2022042537A1 (zh) * | 2020-08-24 | 2022-03-03 | 江苏恒瑞医药股份有限公司 | TGF-β受体的融合蛋白与多靶点酪氨酸激酶抑制剂联合在制备抗肿瘤药物中的用途 |
WO2023040804A1 (zh) * | 2021-09-14 | 2023-03-23 | 信达生物制药(苏州)有限公司 | 抗pd-1抗体和化疗药的药物组合及其使用方法 |
CN115521913B (zh) * | 2022-02-22 | 2023-07-25 | 北京景达生物科技有限公司 | NK细胞与CD20、CD38、Her2抗体联合应用 |
CN116804221B (zh) * | 2023-08-23 | 2023-11-03 | 汲迈生命科技(苏州)有限公司 | Lmo7表达水平在预测胰腺癌吉西他滨耐药中的应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010533203A (ja) | 2007-07-12 | 2010-10-21 | ケモセントリックス, インコーポレイテッド | 炎症の治療のためのccr2モジュレーターとしての縮合ヘテロアリールピリジルおよびフェニルベンゼンスルホンアミド |
US20140031348A1 (en) | 2006-07-14 | 2014-01-30 | Chemocentryx, Inc. | Heteroaryl sulfonamides and ccr2/ccr9 |
JP2020147601A (ja) | 2016-06-13 | 2020-09-17 | ケモセントリックス, インコーポレイテッド | 膵がんを治療する方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS52010B (en) * | 2005-06-22 | 2012-04-30 | Plexxikon Inc. | DERIVATI PIROLO [2, 3-B] PIRIDINA KAO INHIBITORI PROTEIN KINAZE |
CA2669917A1 (en) * | 2006-11-17 | 2008-05-22 | Dawn M. George | Aminopyrrolidines as chemokine receptor antagonists |
US7776877B2 (en) * | 2007-06-22 | 2010-08-17 | Chemocentryx, Inc. | N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides |
BRPI0907236A2 (pt) * | 2008-01-22 | 2017-06-06 | Merck Patent Ges Mit Berschränkter Haftung | inibidores de proteína quinase e uso dos mesmos |
TW201041888A (en) * | 2009-05-06 | 2010-12-01 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
CN102933579B (zh) * | 2009-12-17 | 2015-07-15 | 贝林格尔.英格海姆国际有限公司 | 新的ccr2受体拮抗剂及其用途 |
DK3263564T3 (da) * | 2012-02-29 | 2020-09-07 | Chemocentryx Inc | Aza-aryl-1h-pyrazol-1-yl-benzen-sulfonamider som ccr(9)- antagonister |
JP6523337B2 (ja) * | 2014-05-05 | 2019-05-29 | リセラ・コーポレイションLycera Corporation | RORγのアゴニストとしての使用及び疾患治療のためのベンゼンスルホンアミド及び関連化合物 |
-
2017
- 2017-06-13 BR BR112018075660-1A patent/BR112018075660A2/pt active Search and Examination
- 2017-06-13 SG SG11201810940XA patent/SG11201810940XA/en unknown
- 2017-06-13 CA CA3026515A patent/CA3026515A1/en active Pending
- 2017-06-13 KR KR1020197000640A patent/KR20190017913A/ko not_active IP Right Cessation
- 2017-06-13 WO PCT/US2017/037264 patent/WO2017218544A1/en unknown
- 2017-06-13 AU AU2017283491A patent/AU2017283491B2/en active Active
- 2017-06-13 KR KR1020237010335A patent/KR20230047210A/ko not_active IP Right Cessation
- 2017-06-13 CN CN201780049675.7A patent/CN109562086A/zh active Pending
- 2017-06-13 RU RU2019100220A patent/RU2768479C2/ru active
- 2017-06-13 SG SG10202012434QA patent/SG10202012434QA/en unknown
- 2017-06-13 MX MX2018015172A patent/MX2018015172A/es unknown
- 2017-06-13 ES ES17813938T patent/ES2895749T3/es active Active
- 2017-06-13 EP EP17813938.2A patent/EP3468548B1/en active Active
- 2017-06-13 JP JP2018565305A patent/JP7083214B2/ja active Active
-
2018
- 2018-12-05 IL IL263508A patent/IL263508B2/en unknown
- 2018-12-06 ZA ZA2018/08258A patent/ZA201808258B/en unknown
-
2020
- 2020-06-15 JP JP2020103105A patent/JP2020147601A/ja not_active Withdrawn
- 2020-06-15 JP JP2020103107A patent/JP2020147602A/ja not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20140031348A1 (en) | 2006-07-14 | 2014-01-30 | Chemocentryx, Inc. | Heteroaryl sulfonamides and ccr2/ccr9 |
JP2010533203A (ja) | 2007-07-12 | 2010-10-21 | ケモセントリックス, インコーポレイテッド | 炎症の治療のためのccr2モジュレーターとしての縮合ヘテロアリールピリジルおよびフェニルベンゼンスルホンアミド |
JP2020147601A (ja) | 2016-06-13 | 2020-09-17 | ケモセントリックス, インコーポレイテッド | 膵がんを治療する方法 |
Non-Patent Citations (1)
Title |
---|
Lancet Oncol.,2016年04月04日,Vol.17,pp.651-662 |
Also Published As
Publication number | Publication date |
---|---|
RU2019100220A3 (zh) | 2020-12-24 |
CA3026515A1 (en) | 2017-12-21 |
IL263508B2 (en) | 2023-06-01 |
AU2017283491A1 (en) | 2018-12-20 |
EP3468548A1 (en) | 2019-04-17 |
KR20230047210A (ko) | 2023-04-06 |
IL263508A (en) | 2019-01-31 |
CN109562086A (zh) | 2019-04-02 |
SG10202012434QA (en) | 2021-01-28 |
SG11201810940XA (en) | 2019-01-30 |
JP2020147602A (ja) | 2020-09-17 |
ES2895749T3 (es) | 2022-02-22 |
JP2020147601A (ja) | 2020-09-17 |
RU2768479C2 (ru) | 2022-03-24 |
RU2019100220A (ru) | 2020-07-15 |
KR20190017913A (ko) | 2019-02-20 |
AU2017283491B2 (en) | 2021-06-03 |
EP3468548B1 (en) | 2021-08-04 |
ZA201808258B (en) | 2022-04-28 |
WO2017218544A1 (en) | 2017-12-21 |
EP3468548A4 (en) | 2020-01-22 |
JP2019518038A (ja) | 2019-06-27 |
BR112018075660A2 (pt) | 2019-04-09 |
MX2018015172A (es) | 2019-07-04 |
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