JP7082626B2 - 貼付剤 - Google Patents
貼付剤 Download PDFInfo
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- JP7082626B2 JP7082626B2 JP2019567098A JP2019567098A JP7082626B2 JP 7082626 B2 JP7082626 B2 JP 7082626B2 JP 2019567098 A JP2019567098 A JP 2019567098A JP 2019567098 A JP2019567098 A JP 2019567098A JP 7082626 B2 JP7082626 B2 JP 7082626B2
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- Prior art keywords
- adhesive layer
- pressure
- sensitive adhesive
- content
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- Prior art date
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- 229940079827 sodium hydrogen sulfite Drugs 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003784 tall oil Substances 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229960004380 tramadol Drugs 0.000 description 1
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- ZENOXNGFMSCLLL-UHFFFAOYSA-N vanillyl alcohol Natural products COC1=CC(CO)=CC=C1O ZENOXNGFMSCLLL-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000002759 woven fabric Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
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Description
前記粘着剤層が非水性であり、
前記粘着剤層がノニル酸ワニリルアミド、テルペン系樹脂、ロジン系樹脂、スチレン-イソプレン-スチレンブロック共重合体、流動パラフィン、ポリイソブチレン、並びに、サリチル酸メチル、サリチル酸グリコール、l-メントール、dl-カンフル、ハッカ油、及びチモールからなる群から選択される少なくとも1種の消炎鎮痛剤を含有しており、
前記粘着剤層におけるノニル酸ワニリルアミドの含有量が前記粘着剤層の全質量に対して0.005~0.1質量%であり、
前記粘着剤層における前記テルペン系樹脂の含有量と前記ロジン系樹脂の含有量との質量比(テルペン系樹脂の含有量/ロジン系樹脂の含有量)が0.45~1.3であり、
前記粘着剤層における前記スチレン-イソプレン-スチレンブロック共重合体の含有量と前記流動パラフィンの含有量との質量比(スチレン-イソプレン-スチレンブロック共重合体の含有量/流動パラフィンの含有量)が0.45~1.2であり、
前記粘着剤層における前記スチレン-イソプレン-スチレンブロック共重合体の含有量と前記ポリイソブチレンの含有量との質量比(スチレン-イソプレン-スチレンブロック共重合体の含有量:ポリイソブチレンの含有量)が1:0.28~1:0.58であり、 前記粘着剤層の厚さが250~400μmである、
ものである。
前記粘着剤層が非水性であり、
前記粘着剤層がノニル酸ワニリルアミド、テルペン系樹脂、ロジン系樹脂、スチレン-イソプレン-スチレンブロック共重合体、及び流動パラフィンを含有しており、
前記粘着剤層における前記テルペン系樹脂の含有量と前記ロジン系樹脂の含有量との質量比(テルペン系樹脂の含有量/ロジン系樹脂の含有量)が0.45~1.3であり、
前記粘着剤層における前記スチレン-イソプレン-スチレンブロック共重合体の含有量と前記流動パラフィンの含有量との質量比(スチレン-イソプレン-スチレンブロック共重合体の含有量/流動パラフィンの含有量)が0.45~1.2である。
各貼付剤を直径25mmの円形に切断して剥離ライナーを剥離し、それぞれ、6~7名の被験者に粘着剤層の表面(粘着面)を手指で触ってもらい、粘着剤層の皮膚に対する粘着性を、それぞれ、次の粘着性評価の基準:
〔粘着性評価〕
0 :粘着性が極めて低い
25 :粘着性が低い
50 :粘着性がやや低い
75 :粘着性がやや高い
100:粘着性が極めて高い
に従って評価してもらった。また、前記粘着性評価時における手指表面への粘着剤層(膏体)の残りを、それぞれ、次の粘着剤層残り評価の基準:
〔粘着剤層残り評価〕
0 :粘着剤層が手指表面に気になる程度残った(手指表面の全面に残った)
25 :粘着剤層が手指表面の一部に残った
50 :粘着剤層の手指表面への残りは少なかったが、粘着剤層の表面から手指を剥離する際にかなり糸引きがみられた
75 :粘着剤層の表面から手指を剥離する際にわずかに糸引きがみられた
100:粘着剤層が手指表面に残らず、糸引きもみられなかった
に従って評価してもらった。ここで「糸引き」とは、粘着剤層の凝集力が低い程多くみられる現象であり、粘着剤層の一部が糸を引くように剥がれて粘着剤層が変形することを意味する。
各実施例及び比較例で得られた貼付剤から、室温において粘着剤層を一定量掻き採り、これを115℃に加温して、温度を115℃に保ったままB型粘度計(装置:ビスコテスタVT-04F、製造社:リオン株式会社)のローターを浸して回転させ、このローターに働く粘性抵抗(トルク)を測定し、前記粘着剤層の115℃における粘度(dPa・s)とした。
先ず、ノニル酸ワニリルアミド0.012質量部、オウバク粉末1.70質量部、サリチル酸グリコール2.55質量部、l-メントール5.11質量部、テルペン系樹脂(TP)(YSレジンPX1150N、ヤスハラケミカル株式会社製)5.00質量部、ロジン系樹脂(RS)(パインクリスタルKE-311、荒川化学工業株式会社製)10.00質量部、スチレン-イソプレン-スチレンブロック共重合体(SIS)21.79質量部、ポリイソブチレン9.40質量部、流動パラフィン(LP)40.828質量部、及びその他成分(酸化防止剤、充填剤)3.61質量部を混合し、粘着剤層組成物を得た。次いで、得られた粘着剤層組成物を剥離ライナー(離型処理が施されたポリエチレンテレフタレート製フィルム)上に塗布して、粘着剤層の厚さが320μmとなるように粘着剤層を形成した。得られた粘着剤層の前記剥離ライナーと反対の面上に支持体層(ポリエステル製不織布)を積層し、支持体層/粘着剤層/剥離ライナーの順に積層された貼付剤を得た。
粘着剤層組成物の組成を下記の表1~2に示す組成となるようにしたこと以外は実施例1と同様にして、各貼付剤を得た。
粘着剤層組成物の組成を下記の表3に示す組成となるようにし、かつ、粘着剤層の厚さを260μm(比較例7)又は400μm(比較例8)としたこと以外は実施例1と同様にして、各貼付剤を得た。
粘着剤層組成物の組成を下記の表4に示す組成となるようにし、かつ、粘着剤層の厚さを250μm(実施例6)又は400μm(実施例7)としたこと以外は実施例1と同様にして、各貼付剤を得た。
粘着剤層組成物の組成を下記の表4に示す組成となるようにしたこと以外は実施例1と同様にして、各貼付剤を得た。
Claims (4)
- 支持体層及び粘着剤層を備える貼付剤であり、
前記粘着剤層が非水性であり、
前記粘着剤層がノニル酸ワニリルアミド、テルペン系樹脂、ロジン系樹脂、スチレン-イソプレン-スチレンブロック共重合体、流動パラフィン、ポリイソブチレン、並びに、サリチル酸メチル、サリチル酸グリコール、l-メントール、dl-カンフル、ハッカ油、及びチモールからなる群から選択される少なくとも1種の消炎鎮痛剤を含有しており、
前記粘着剤層におけるノニル酸ワニリルアミドの含有量が前記粘着剤層の全質量に対して0.005~0.1質量%であり、
前記粘着剤層における前記テルペン系樹脂の含有量と前記ロジン系樹脂の含有量との質量比(テルペン系樹脂の含有量/ロジン系樹脂の含有量)が0.45~1.3であり、
前記粘着剤層における前記スチレン-イソプレン-スチレンブロック共重合体の含有量と前記流動パラフィンの含有量との質量比(スチレン-イソプレン-スチレンブロック共重合体の含有量/流動パラフィンの含有量)が0.45~1.2であり、
前記粘着剤層における前記スチレン-イソプレン-スチレンブロック共重合体の含有量と前記ポリイソブチレンの含有量との質量比(スチレン-イソプレン-スチレンブロック共重合体の含有量:ポリイソブチレンの含有量)が1:0.28~1:0.58であり、 前記粘着剤層の厚さが250~400μmである、
貼付剤。 - 前記粘着剤層が実質的に水を含有していない、請求項1に記載の貼付剤。
- 前記粘着剤層における前記消炎鎮痛剤の含有量が、前記粘着剤層の全質量に対して1~10質量%である、請求項1又は2に記載の貼付剤。
- B型粘度計により115℃において測定される前記粘着剤層の粘度が100~2500dPa・sである、請求項1~3のうちのいずれか一項に記載の貼付剤。
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JP2007269753A (ja) | 2006-03-31 | 2007-10-18 | Nichiban Co Ltd | 局所適用型経皮吸収テープ剤 |
JP2008179564A (ja) | 2007-01-25 | 2008-08-07 | Nichiban Co Ltd | 消炎鎮痛貼付剤 |
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JP2014177428A (ja) | 2013-03-15 | 2014-09-25 | Yutoku Yakuhin Kogyo Kk | ロジン系樹脂を含有するロチゴチン経皮吸収型貼付製剤 |
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WO2017146096A1 (ja) | 2016-02-25 | 2017-08-31 | 久光製薬株式会社 | 貼付剤 |
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EP1568365B1 (en) | 2002-11-27 | 2018-04-11 | Hisamitsu Pharmaceutical Co. Inc. | Warm poultice |
SG176133A1 (en) * | 2009-07-24 | 2011-12-29 | Teikoku Seiyaku Kk | Fentanyl-containing adhesive preparation for external use |
BR112013028802B1 (pt) | 2011-05-10 | 2021-10-26 | Itochu Chemical Frontier Corporation | Curativo adesivo não-aquoso |
US10022336B2 (en) * | 2012-11-30 | 2018-07-17 | Teikoku Seiyaku Co., Ltd. | Ropinirole-containing adhesive patch |
CN106806893A (zh) | 2015-11-30 | 2017-06-09 | 北京泰德制药股份有限公司 | 含有钙敏感受体激动剂的皮肤外用贴剂 |
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JP2007269753A (ja) | 2006-03-31 | 2007-10-18 | Nichiban Co Ltd | 局所適用型経皮吸収テープ剤 |
JP2008179564A (ja) | 2007-01-25 | 2008-08-07 | Nichiban Co Ltd | 消炎鎮痛貼付剤 |
JP2014076960A (ja) | 2012-10-10 | 2014-05-01 | Nichiban Co Ltd | ホットメルト型粘着剤組成物及び経皮吸収貼付剤 |
JP2014177428A (ja) | 2013-03-15 | 2014-09-25 | Yutoku Yakuhin Kogyo Kk | ロジン系樹脂を含有するロチゴチン経皮吸収型貼付製剤 |
WO2016103999A1 (ja) | 2014-12-26 | 2016-06-30 | ニチバン株式会社 | 貼付剤のための包装体および包装方法 |
WO2017146096A1 (ja) | 2016-02-25 | 2017-08-31 | 久光製薬株式会社 | 貼付剤 |
WO2017170935A1 (ja) | 2016-03-31 | 2017-10-05 | ニチバン株式会社 | 経皮吸収製剤 |
JP2018168125A (ja) | 2017-03-30 | 2018-11-01 | ニチバン株式会社 | 貼付剤 |
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CN111615382A (zh) | 2020-09-01 |
TW201940161A (zh) | 2019-10-16 |
EP3744321B1 (en) | 2023-04-12 |
TWI734952B (zh) | 2021-08-01 |
KR20200106175A (ko) | 2020-09-11 |
US20200352872A1 (en) | 2020-11-12 |
KR102409291B1 (ko) | 2022-06-14 |
JPWO2019146614A1 (ja) | 2020-12-10 |
US11166921B2 (en) | 2021-11-09 |
WO2019146614A1 (ja) | 2019-08-01 |
CN111615382B (zh) | 2023-05-05 |
EP3744321A4 (en) | 2021-10-27 |
SG11202007131UA (en) | 2020-08-28 |
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