JP7068825B2 - Ｃｄ３８に結合する抗体治療剤 - Google Patents

Ｃｄ３８に結合する抗体治療剤 Download PDF

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Publication number
JP7068825B2
JP7068825B2 JP2017552973A JP2017552973A JP7068825B2 JP 7068825 B2 JP7068825 B2 JP 7068825B2 JP 2017552973 A JP2017552973 A JP 2017552973A JP 2017552973 A JP2017552973 A JP 2017552973A JP 7068825 B2 JP7068825 B2 JP 7068825B2
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seq
antibody
chain variable
variable domain
antigen
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JP2018513149A (ja
JP2018513149A5 (enExample
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ヘユー・ジョウ
ジョン・ディクソン・グレイ
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Sorrento Therapeutics Inc
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Priority to JP2021086783A priority Critical patent/JP7273101B2/ja
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Priority to JP2022101169A priority patent/JP2022118222A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cell Biology (AREA)
JP2017552973A 2015-04-08 2016-04-08 Ｃｄ３８に結合する抗体治療剤 Expired - Fee Related JP7068825B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021086783A JP7273101B2 (ja) 2015-04-08 2021-05-24 Ｃｄ３８に結合する抗体治療剤
JP2022101169A JP2022118222A (ja) 2015-04-08 2022-06-23 Ｃｄ３８に結合する抗体治療剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562144901P 2015-04-08 2015-04-08
US62/144,901 2015-04-08
PCT/US2016/026567 WO2016164669A2 (en) 2015-04-08 2016-04-08 Antibody therapeutics that bind cd38

Related Child Applications (1)

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JP2021086783A Division JP7273101B2 (ja) 2015-04-08 2021-05-24 Ｃｄ３８に結合する抗体治療剤

Publications (3)

Publication Number Publication Date
JP2018513149A JP2018513149A (ja) 2018-05-24
JP2018513149A5 JP2018513149A5 (enExample) 2019-05-16
JP7068825B2 true JP7068825B2 (ja) 2022-05-17

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JP2017552973A Expired - Fee Related JP7068825B2 (ja) 2015-04-08 2016-04-08 Ｃｄ３８に結合する抗体治療剤
JP2021086783A Active JP7273101B2 (ja) 2015-04-08 2021-05-24 Ｃｄ３８に結合する抗体治療剤
JP2022101169A Pending JP2022118222A (ja) 2015-04-08 2022-06-23 Ｃｄ３８に結合する抗体治療剤

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JP2021086783A Active JP7273101B2 (ja) 2015-04-08 2021-05-24 Ｃｄ３８に結合する抗体治療剤
JP2022101169A Pending JP2022118222A (ja) 2015-04-08 2022-06-23 Ｃｄ３８に結合する抗体治療剤

Country Status (8)

Country Link
US (4) US10059774B2 (enExample)
EP (2) EP4180058A1 (enExample)
JP (3) JP7068825B2 (enExample)
CN (2) CN107921122B (enExample)
AR (1) AR104213A1 (enExample)
ES (1) ES2927119T3 (enExample)
TW (1) TW201702264A (enExample)
WO (2) WO2016164656A1 (enExample)

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US10100118B2 (en) * 2015-04-08 2018-10-16 Sorrento Therapeutics, Inc. Antibody therapeutics that bind CD123
US10059774B2 (en) 2015-04-08 2018-08-28 Sorrento Therapeutics, Inc. Antibody therapeutics that bind CD38
AU2018273914A1 (en) 2017-05-24 2019-11-14 Pandion Operations, Inc. Targeted immunotolerance
TWI843344B (zh) 2017-06-02 2024-05-21 美商輝瑞大藥廠 對ｆｌｔ３具特異性之抗體及其用途
EP3635001A1 (en) 2017-06-08 2020-04-15 Black Belt Therapeutics Limited Cd38 modulating antibody
EP3635002A1 (en) 2017-06-08 2020-04-15 Black Belt Therapeutics Limited Cd38 modulating antibody
CA3067311A1 (en) * 2017-06-20 2018-12-27 Sorrento Therapeutics, Inc. Cd38 antibody drug conjugate
KR102770107B1 (ko) 2017-08-16 2025-02-20 블랙 벨트 테라퓨틱스 리미티드 Cd38 조정 항체
WO2019035938A1 (en) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
US11542338B2 (en) 2017-08-16 2023-01-03 Black Belt Therapeutics Limited CD38 modulating antibody
KR102770110B1 (ko) 2017-08-16 2025-02-20 블랙 벨트 테라퓨틱스 리미티드 Cd38 항체
EP3704156A1 (en) * 2017-11-03 2020-09-09 Sorrento Therapeutics, Inc. Cd38-directed chimeric antigen receptor constructs
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
CN112105649B (zh) 2018-03-09 2025-09-05 索伦托药业有限公司 二聚体抗原受体(dar)
EP3810655A4 (en) * 2018-06-20 2022-03-16 Sorrento Therapeutics, Inc. CD38-BINDING ANTIBODY VARIANT
CA3111651A1 (en) * 2018-09-11 2020-03-19 Jiangsu Hengrui Medicine Co., Ltd. Anti-cd38 antibody, antigen-binding fragment thereof, and pharmaceutical use
CA3134612A1 (en) * 2019-03-29 2020-10-08 Sorrento Therapeutics, Inc. Engineered variant antibodies that bind cd38
TW202110885A (zh) 2019-05-20 2021-03-16 美商潘迪恩治療公司 靶向ＭＡｄＣＡＭ之免疫耐受性
US20250263440A1 (en) * 2019-07-03 2025-08-21 Peptidream Inc. Cd38-binding agents and uses thereof
CN114728179A (zh) * 2019-08-19 2022-07-08 潘迪恩运营公司 利用pd-1激动剂的靶向免疫耐受
US20210221886A1 (en) 2019-12-05 2021-07-22 Sorrento Therapeutics, Inc. Compositions and Methods Comprising an Anti-CD47 Antibody in Combination with a Tumor Targeting Antibody
WO2021168079A1 (en) 2020-02-21 2021-08-26 Pandion Operations, Inc. Tissue targeted immunotolerance with a cd39 effector
EP4107189A4 (en) * 2020-02-21 2024-07-03 Pandion Operations, Inc. TISSUE-TARGETED IMMUNOTOLERANCE WITH PD-1 AGONISTS OR IL-2 MUTEINS
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CN116368155A (zh) * 2020-08-19 2023-06-30 潘迪恩运营公司 多互补位抗pd-1抗体及其用途
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Non-Patent Citations (1)

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Title
Ｃｌｉｎ．Ｃａｎｃｅｒ Ｒｅｓ．，２０１４年，Ｖｏｌ．２０，Ｎｏ．１７，ｐ．４５７４－４５８３

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JP2021118754A (ja) 2021-08-12
US20190048092A1 (en) 2019-02-14
JP2022118222A (ja) 2022-08-12
WO2016164669A3 (en) 2017-01-12
EP3280443A4 (en) 2018-12-26
EP3280443B1 (en) 2022-08-24
EP4180058A1 (en) 2023-05-17
JP2018513149A (ja) 2018-05-24
US11999792B2 (en) 2024-06-04
TW201702264A (zh) 2017-01-16
US10059774B2 (en) 2018-08-28
HK1253584A1 (zh) 2019-06-21
EP3280443A2 (en) 2018-02-14
US9951144B2 (en) 2018-04-24
JP7273101B2 (ja) 2023-05-12
ES2927119T3 (es) 2022-11-02
AR104213A1 (es) 2017-07-05
CN107921122B (zh) 2021-08-10
WO2016164669A2 (en) 2016-10-13
US20200399395A1 (en) 2020-12-24
WO2016164656A1 (en) 2016-10-13
CN107921122A (zh) 2018-04-17
US10800852B2 (en) 2020-10-13
US20170291959A1 (en) 2017-10-12
CN113527495A (zh) 2021-10-22
US20160297888A1 (en) 2016-10-13

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