JP7068166B2 - ファージミドベクター - Google Patents
ファージミドベクター Download PDFInfo
- Publication number
- JP7068166B2 JP7068166B2 JP2018521571A JP2018521571A JP7068166B2 JP 7068166 B2 JP7068166 B2 JP 7068166B2 JP 2018521571 A JP2018521571 A JP 2018521571A JP 2018521571 A JP2018521571 A JP 2018521571A JP 7068166 B2 JP7068166 B2 JP 7068166B2
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- Prior art keywords
- phagemid
- aav
- vector
- recombinant
- particles
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14144—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
- C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/00041—Use of virus, viral particle or viral elements as a vector
- C12N2795/00043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/00041—Use of virus, viral particle or viral elements as a vector
- C12N2795/00044—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
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- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/00041—Use of virus, viral particle or viral elements as a vector
- C12N2795/00045—Special targeting system for viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/14011—Details ssDNA Bacteriophages
- C12N2795/14111—Inoviridae
- C12N2795/14134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/14011—Details ssDNA Bacteriophages
- C12N2795/14111—Inoviridae
- C12N2795/14141—Use of virus, viral particle or viral elements as a vector
- C12N2795/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/14011—Details ssDNA Bacteriophages
- C12N2795/14111—Inoviridae
- C12N2795/14141—Use of virus, viral particle or viral elements as a vector
- C12N2795/14144—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
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- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/14011—Details ssDNA Bacteriophages
- C12N2795/14111—Inoviridae
- C12N2795/14151—Methods of production or purification of viral material
- C12N2795/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/04—Uses of viruses as vector in vivo
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/06—Uses of viruses as vector in vitro
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- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
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- C12N2810/00—Vectors comprising a targeting moiety
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- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
- C12N2810/405—Vectors comprising RGD peptide
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- C12N2820/00—Vectors comprising a special origin of replication system
- C12N2820/10—Vectors comprising a special origin of replication system multiple origins of replication
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- C12N2820/00—Vectors comprising a special origin of replication system
- C12N2820/55—Vectors comprising a special origin of replication system from bacteria
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- C12N2820/00—Vectors comprising a special origin of replication system
- C12N2820/60—Vectors comprising a special origin of replication system from viruses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022075036A JP2022115934A (ja) | 2015-11-02 | 2022-04-28 | ファージミドベクター |
| JP2024076613A JP2024102282A (ja) | 2015-11-02 | 2024-05-09 | ファージミドベクター |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1519303.0A GB201519303D0 (en) | 2015-11-02 | 2015-11-02 | Phagemid vector |
| GB1519303.0 | 2015-11-02 | ||
| PCT/GB2016/053366 WO2017077275A1 (en) | 2015-11-02 | 2016-10-31 | Phagemid vector |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022075036A Division JP2022115934A (ja) | 2015-11-02 | 2022-04-28 | ファージミドベクター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018533949A JP2018533949A (ja) | 2018-11-22 |
| JP2018533949A5 JP2018533949A5 (enExample) | 2019-10-24 |
| JP7068166B2 true JP7068166B2 (ja) | 2022-05-16 |
Family
ID=55130522
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521571A Active JP7068166B2 (ja) | 2015-11-02 | 2016-10-31 | ファージミドベクター |
| JP2022075036A Pending JP2022115934A (ja) | 2015-11-02 | 2022-04-28 | ファージミドベクター |
| JP2024076613A Pending JP2024102282A (ja) | 2015-11-02 | 2024-05-09 | ファージミドベクター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022075036A Pending JP2022115934A (ja) | 2015-11-02 | 2022-04-28 | ファージミドベクター |
| JP2024076613A Pending JP2024102282A (ja) | 2015-11-02 | 2024-05-09 | ファージミドベクター |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11603540B2 (enExample) |
| EP (2) | EP4163382A1 (enExample) |
| JP (3) | JP7068166B2 (enExample) |
| CA (1) | CA3040230A1 (enExample) |
| DK (1) | DK3371315T3 (enExample) |
| GB (1) | GB201519303D0 (enExample) |
| WO (1) | WO2017077275A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201519303D0 (en) | 2015-11-02 | 2015-12-16 | Imp Innovations Ltd | Phagemid vector |
| GB201706090D0 (en) * | 2017-04-18 | 2017-05-31 | Glaxosmithkline Ip Dev Ltd | Methods for adeno-associated viral vector production |
| CA3058970A1 (en) | 2017-04-18 | 2018-10-25 | Glaxosmithkline Intellectual Property Development Limited | Methods for adeno-associated viral vector production |
| GB201706451D0 (en) * | 2017-04-24 | 2017-06-07 | Imp Innovations Ltd | Cancer treatment |
| KR102877876B1 (ko) * | 2018-05-08 | 2025-10-28 | 루트거스, 더 스테이트 유니버시티 오브 뉴 저지 | Aav-상용성 라미닌-링커 중합 단백질 |
| CA3104833A1 (en) * | 2018-07-16 | 2020-01-23 | Dcprime B.V. | A combination product for use in tumor vaccination. |
| EP3844289A4 (en) * | 2018-08-29 | 2022-07-20 | Shanghaitech University | COMPOSITION AND USE OF CAS PROTEIN INHIBITORS |
| GB201816919D0 (en) * | 2018-10-17 | 2018-11-28 | Glaxosmithkline Ip Dev Ltd | Adeno-associated viral vector producer cell lines |
| CN110235467B (zh) * | 2019-04-30 | 2021-11-02 | 北京小米移动软件有限公司 | 小区重配方法及装置 |
| WO2022010813A2 (en) * | 2020-07-06 | 2022-01-13 | Rutgers, The State University Of New Jersey | Enhancing immune responses through targeted antigen expression |
| WO2022072324A1 (en) * | 2020-09-29 | 2022-04-07 | NeuExcell Therapeutics Inc. | Isl1 and lhx3 vector |
| WO2024149989A1 (en) * | 2023-01-10 | 2024-07-18 | Imperial College Innovations Limited | Phage vector |
| WO2024243134A2 (en) * | 2023-05-19 | 2024-11-28 | Academia Sinica | Engineered bacteriophage particle and method of gene therapy by using same |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009534314A (ja) | 2006-04-07 | 2009-09-24 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | アデノ随伴ウイルスファージ粒子に関する方法および組成物 |
| JP2013143940A (ja) | 1997-09-05 | 2013-07-25 | Ampliphi Biosciences Inc | 組換えaavベクターの高力価ヘルパーなし調製物を生成するための方法 |
| WO2014184529A1 (en) | 2013-05-15 | 2014-11-20 | Imperial Innovations Plc | Bacteriophage |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992009690A2 (en) * | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| EP1660636A4 (en) | 2003-08-26 | 2009-07-01 | Univ Texas | VACCINES AGAINST CANCER |
| EP1960526A4 (en) | 2005-12-07 | 2009-07-15 | Los Alamos Nat Security Llc | PLASMIDES AND PACKAGING CELL LINES FOR USE IN A PHAG DISPLAY |
| JP2013527753A (ja) | 2010-03-23 | 2013-07-04 | イントレキソン コーポレーション | 治療タンパク質を条件的に発現するベクター、該ベクターを含む宿主細胞およびそれらの使用 |
| GB201308742D0 (en) | 2013-05-15 | 2013-06-26 | Imp Innovations | Bacteriophage |
| WO2015105806A2 (en) | 2014-01-07 | 2015-07-16 | Oklahoma Medical Research Foundation | Antibodies against glioma biomarkers |
| AU2016334401A1 (en) | 2015-10-10 | 2018-04-26 | Intrexon Corporation | Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12 |
| GB201519303D0 (en) | 2015-11-02 | 2015-12-16 | Imp Innovations Ltd | Phagemid vector |
| GB201706451D0 (en) | 2017-04-24 | 2017-06-07 | Imp Innovations Ltd | Cancer treatment |
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| JP2013143940A (ja) | 1997-09-05 | 2013-07-25 | Ampliphi Biosciences Inc | 組換えaavベクターの高力価ヘルパーなし調製物を生成するための方法 |
| JP2009534314A (ja) | 2006-04-07 | 2009-09-24 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | アデノ随伴ウイルスファージ粒子に関する方法および組成物 |
| WO2014184529A1 (en) | 2013-05-15 | 2014-11-20 | Imperial Innovations Plc | Bacteriophage |
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| ZONGHAI LI,CELL-TARGETED PHAGEMID PARTICLES PREPARATION USING ESCHERICHIA COLI BEARING LIGAND-PIII ENCODING HELPER PHAGE GENOME,BIOTECHNIQUES RAPID DISPATCHES,米国,2006年12月,VOL:41, NR:6,PAGE(S):706 - 707,http://dx.doi.org/10.2144/000112294 |
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| EP4163382A1 (en) | 2023-04-12 |
| US11603540B2 (en) | 2023-03-14 |
| WO2017077275A1 (en) | 2017-05-11 |
| GB201519303D0 (en) | 2015-12-16 |
| EP3371315A1 (en) | 2018-09-12 |
| JP2024102282A (ja) | 2024-07-30 |
| JP2018533949A (ja) | 2018-11-22 |
| US20180320200A1 (en) | 2018-11-08 |
| JP2022115934A (ja) | 2022-08-09 |
| DK3371315T3 (da) | 2022-12-05 |
| EP3371315B1 (en) | 2022-08-31 |
| US12331308B2 (en) | 2025-06-17 |
| US20230265452A1 (en) | 2023-08-24 |
| CA3040230A1 (en) | 2017-05-11 |
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