JP2018533949A5 - - Google Patents
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- Publication number
- JP2018533949A5 JP2018533949A5 JP2018521571A JP2018521571A JP2018533949A5 JP 2018533949 A5 JP2018533949 A5 JP 2018533949A5 JP 2018521571 A JP2018521571 A JP 2018521571A JP 2018521571 A JP2018521571 A JP 2018521571A JP 2018533949 A5 JP2018533949 A5 JP 2018533949A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant
- phagemid
- aav
- particle
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims 53
- 210000004027 cell Anatomy 0.000 claims 30
- 239000013598 vector Substances 0.000 claims 19
- 108090000623 proteins and genes Proteins 0.000 claims 18
- 108700019146 Transgenes Proteins 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- 238000004806 packaging method and process Methods 0.000 claims 9
- 230000008685 targeting Effects 0.000 claims 8
- 108090000565 Capsid Proteins Proteins 0.000 claims 6
- 102100023321 Ceruloplasmin Human genes 0.000 claims 6
- 230000015572 biosynthetic process Effects 0.000 claims 5
- 230000010076 replication Effects 0.000 claims 5
- 108020004414 DNA Proteins 0.000 claims 4
- 102000053602 DNA Human genes 0.000 claims 4
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 4
- 230000029142 excretion Effects 0.000 claims 4
- 239000013603 viral vector Substances 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- MZVQCMJNVPIDEA-UHFFFAOYSA-N [CH2]CN(CC)CC Chemical group [CH2]CN(CC)CC MZVQCMJNVPIDEA-UHFFFAOYSA-N 0.000 claims 3
- 210000000234 capsid Anatomy 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 238000011065 in-situ storage Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 241001515965 unidentified phage Species 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- 239000013607 AAV vector Substances 0.000 claims 2
- 241000702421 Dependoparvovirus Species 0.000 claims 2
- 229920002873 Polyethylenimine Polymers 0.000 claims 2
- 101710172711 Structural protein Proteins 0.000 claims 2
- 229920006317 cationic polymer Polymers 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 238000001415 gene therapy Methods 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 238000004020 luminiscence type Methods 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 101710132601 Capsid protein Proteins 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 101710094648 Coat protein Proteins 0.000 claims 1
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 claims 1
- 108010041986 DNA Vaccines Proteins 0.000 claims 1
- 229940021995 DNA vaccine Drugs 0.000 claims 1
- 229920002491 Diethylaminoethyl-dextran Polymers 0.000 claims 1
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 claims 1
- 229920000209 Hexadimethrine bromide Polymers 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 101710125418 Major capsid protein Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 101710141454 Nucleoprotein Proteins 0.000 claims 1
- 101710083689 Probable capsid protein Proteins 0.000 claims 1
- 102000007327 Protamines Human genes 0.000 claims 1
- 108010007568 Protamines Proteins 0.000 claims 1
- 241000256251 Spodoptera frugiperda Species 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- -1 cationic lipid Chemical class 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 210000003292 kidney cell Anatomy 0.000 claims 1
- 229940023041 peptide vaccine Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 229950008679 protamine sulfate Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022075036A JP7854334B2 (ja) | 2015-11-02 | 2022-04-28 | ファージミドベクター |
| JP2024076613A JP2024102282A (ja) | 2015-11-02 | 2024-05-09 | ファージミドベクター |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1519303.0A GB201519303D0 (en) | 2015-11-02 | 2015-11-02 | Phagemid vector |
| GB1519303.0 | 2015-11-02 | ||
| PCT/GB2016/053366 WO2017077275A1 (en) | 2015-11-02 | 2016-10-31 | Phagemid vector |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022075036A Division JP7854334B2 (ja) | 2015-11-02 | 2022-04-28 | ファージミドベクター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018533949A JP2018533949A (ja) | 2018-11-22 |
| JP2018533949A5 true JP2018533949A5 (enExample) | 2019-10-24 |
| JP7068166B2 JP7068166B2 (ja) | 2022-05-16 |
Family
ID=55130522
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018521571A Active JP7068166B2 (ja) | 2015-11-02 | 2016-10-31 | ファージミドベクター |
| JP2022075036A Active JP7854334B2 (ja) | 2015-11-02 | 2022-04-28 | ファージミドベクター |
| JP2024076613A Pending JP2024102282A (ja) | 2015-11-02 | 2024-05-09 | ファージミドベクター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022075036A Active JP7854334B2 (ja) | 2015-11-02 | 2022-04-28 | ファージミドベクター |
| JP2024076613A Pending JP2024102282A (ja) | 2015-11-02 | 2024-05-09 | ファージミドベクター |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11603540B2 (enExample) |
| EP (2) | EP3371315B1 (enExample) |
| JP (3) | JP7068166B2 (enExample) |
| DK (1) | DK3371315T3 (enExample) |
| GB (1) | GB201519303D0 (enExample) |
| WO (1) | WO2017077275A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201519303D0 (en) | 2015-11-02 | 2015-12-16 | Imp Innovations Ltd | Phagemid vector |
| BR112019021595A2 (pt) | 2017-04-18 | 2020-05-12 | Glaxosmithkline Intellectual Property Development Limited | Célula produtora de vírus adeno-associado, vetor de ácido nucleico, métodos para produzir uma linhagem de células de empacotamento estável de vírus adeno-associado e uma partícula de vetor de vírus adeno-associado com defeito de replicação, célula de empacotamento de vírus adeno-associado, e, partícula de vetor de vírus adeno-associado com defeito de replicação. |
| GB201706090D0 (en) * | 2017-04-18 | 2017-05-31 | Glaxosmithkline Ip Dev Ltd | Methods for adeno-associated viral vector production |
| GB201706451D0 (en) * | 2017-04-24 | 2017-06-07 | Imp Innovations Ltd | Cancer treatment |
| KR102877876B1 (ko) * | 2018-05-08 | 2025-10-28 | 루트거스, 더 스테이트 유니버시티 오브 뉴 저지 | Aav-상용성 라미닌-링커 중합 단백질 |
| CA3104833A1 (en) * | 2018-07-16 | 2020-01-23 | Dcprime B.V. | A combination product for use in tumor vaccination. |
| CN112654711B (zh) * | 2018-08-29 | 2024-03-26 | 上海科技大学 | Cas蛋白抑制剂的组合物及应用 |
| GB201816919D0 (en) * | 2018-10-17 | 2018-11-28 | Glaxosmithkline Ip Dev Ltd | Adeno-associated viral vector producer cell lines |
| US20250088915A1 (en) * | 2019-04-30 | 2025-03-13 | Beijing Xiaomi Mobile Software Co., Ltd. | Methods and apparatuses for reconfiguring a cell |
| EP4175674A4 (en) * | 2020-07-06 | 2024-08-14 | Rutgers, the State University of New Jersey | INCREASING IMMUNE RESPONSES THROUGH TARGETED ANTIGEN EXPRESSION |
| MX2023003655A (es) | 2020-09-29 | 2023-06-22 | Neuexcell Therapeutics Inc | Vector neurod1. |
| US20220098616A1 (en) * | 2020-09-29 | 2022-03-31 | NeuExcell Therapeutics Inc. | ISL1 and LHX3 VECTOR |
| WO2024149989A1 (en) * | 2023-01-10 | 2024-07-18 | Imperial College Innovations Limited | Phage vector |
| TWI909459B (zh) * | 2023-05-19 | 2025-12-21 | 中央研究院 | 工程化噬菌體顆粒及使用該噬菌體顆粒進行基因治療的方法 |
| WO2025260044A1 (en) * | 2024-06-13 | 2025-12-18 | Rutgers, The State University Of New Jersey | Ligand-directed gene editing approaches |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| CA2995542A1 (en) * | 1997-09-05 | 1999-03-11 | Genzyme Corporation | Methods for generating high titer helper-free preparations of recombinant aav vectors |
| AU2004267506A1 (en) | 2003-08-26 | 2005-03-03 | Board Of Regents, The University Of Texas System | Anti-cancer vaccines |
| EP1960526A4 (en) | 2005-12-07 | 2009-07-15 | Los Alamos Nat Security Llc | PLASMIDES AND PACKAGING CELL LINES FOR USE IN A PHAG DISPLAY |
| EP2009990B1 (en) | 2006-04-07 | 2016-09-21 | The Board of Regents of The University of Texas System | Methods and compositions related to adenoassociated virus-phage particles |
| EP2550359B1 (en) | 2010-03-23 | 2017-08-09 | Intrexon Corporation | Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof |
| GB201308745D0 (en) | 2013-05-15 | 2013-06-26 | Imp Innovations | Bacteriophage |
| GB201308742D0 (en) * | 2013-05-15 | 2013-06-26 | Imp Innovations | Bacteriophage |
| US10030076B2 (en) | 2014-01-07 | 2018-07-24 | Oklahoma Medical Research Foundation | Antibodies against glioma biomarkers |
| AU2016334401A1 (en) | 2015-10-10 | 2018-04-26 | Intrexon Corporation | Improved therapeutic control of proteolytically sensitive, destabilized forms of interleukin-12 |
| GB201519303D0 (en) | 2015-11-02 | 2015-12-16 | Imp Innovations Ltd | Phagemid vector |
| GB201706451D0 (en) | 2017-04-24 | 2017-06-07 | Imp Innovations Ltd | Cancer treatment |
-
2015
- 2015-11-02 GB GBGB1519303.0A patent/GB201519303D0/en not_active Ceased
-
2016
- 2016-10-31 JP JP2018521571A patent/JP7068166B2/ja active Active
- 2016-10-31 DK DK16790687.4T patent/DK3371315T3/da active
- 2016-10-31 EP EP16790687.4A patent/EP3371315B1/en active Active
- 2016-10-31 EP EP22192071.3A patent/EP4163382A1/en active Pending
- 2016-10-31 WO PCT/GB2016/053366 patent/WO2017077275A1/en not_active Ceased
- 2016-10-31 US US15/772,961 patent/US11603540B2/en active Active
-
2022
- 2022-04-28 JP JP2022075036A patent/JP7854334B2/ja active Active
- 2022-09-29 US US17/956,257 patent/US12331308B2/en active Active
-
2024
- 2024-05-09 JP JP2024076613A patent/JP2024102282A/ja active Pending
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