JP7044273B2 - Composition for suppressing increase in triglyceride in blood - Google Patents

Description

The present invention relates to a composition for suppressing the increase in triglyceride in blood, and more particularly to a composition for suppressing the increase in triglyceride in blood containing terminaria and specific other components.

Terminalia is a plant of the Combretaceae family and is used as a medicine in India. Its fruits have been used mainly as an antidiarrheal agent, and ripe fruits have been used as an antidiarrheal agent.

In recent years, this terminaria has been found to have an effect of preventing vascular fibrosis, and has been found to be used as a preventive or therapeutic agent for vascular fibrosis (see, for example, Patent Document 1). However, the other effects of Terminaria have not been sufficiently studied.
Japanese Unexamined Patent Publication No. 2004-75584

The present inventors have confirmed the effect of suppressing the increase in triglyceride in blood by combining Terminaria with a wide variety of other components. In a specific combination, the neutral fat in blood of Terminaria alone or a specific other component alone We have found that the ability to suppress the increase in triglyceride in blood is dramatically improved as compared with the ability to suppress the increase, and have completed the present invention. That is, it was found that the ability to suppress the increase in triglyceride in blood can be synergistically improved by combining Terminaria with a specific other component. An object of the present invention is to provide a composition having a dramatically improved action of suppressing the increase in triglyceride in blood.

The present inventors have tested combinations of Terminaria and a wide variety of other components, and diligently investigated and studied the effect of suppressing the increase in triglyceride in blood. We have found that it can be dramatically improved, and have completed the present invention. That is, by combining a specific other component having little or little effect of suppressing the increase in triglyceride in blood with Terminaria, the blood of the specific other component is compared with the case of Terminaria alone or the specific other component alone. It was found that the effect of suppressing the increase in triglyceride can be dramatically improved.

That is, the present invention is as follows.
(1) A composition comprising a Terminaria-treated product and at least one component selected from the group consisting of the following (a) to (h).
(A) At least one green leaf selected from young barley leaves and young leaves of sweet potato (b) Antioxidant which is astaxanthin (c) Polysaccharide which is chitosan (d) At least one spice selected from pepper, long pepper and black ginger (E) At least one fungus selected from lactic acid bacteria and yeast (f) At least one fermented product selected from grain fermented product and black vinegar (g) At least selected from vitamin B12, vitamin B5, vitamin B2 and vitamin B1 Vitamin B group (h) Plant extract extracted from at least one plant selected from pine bark, kudzu flower, gymnema, ginger and salasia (2) Terminaria treated product and the following (a) to (h) A composition for suppressing an increase in neutral fat in blood, which comprises at least one component selected from the group.
(A) At least one green leaf selected from young barley leaves and young leaves of sweet potato (b) Antioxidant which is astaxanthin (c) Polysaccharide which is chitosan (d) At least one spice selected from pepper, long pepper and black ginger (E) At least one fungus selected from lactic acid bacteria and yeast (f) At least one fermented product selected from grain fermented product and black vinegar (g) At least selected from vitamin B12, vitamin B5, vitamin B2 and vitamin B1 Vitamin B group (h) Plant extract extracted from at least one plant selected from pine bark, kudzu flower, gymnema, ginger and salasia (3) Terminaria and selected from the group consisting of (a) to (h) The composition according to (1) or (2), wherein the compounding mass ratio with at least one of the components is in the range of 0.5: 1 to 70: 1.
(4) The composition according to any one of (1) to (3), which is liquid, powdery or granular.
(5) The composition according to any one of (1) to (4), which is an instant powdered beverage or an instant granule beverage.
(6) The composition according to (5), which is a packaging composition containing 3 to 10 g of an instant powdered beverage or an instant granule beverage.
(7) The composition according to any one of (1) to (4), which is a packaged beverage.
(8) An agent for suppressing the increase in triglyceride in blood, which comprises a terminaria-treated product and at least one component selected from the group consisting of the following (a) to (h).
(A) At least one green leaf selected from young barley leaves and young sweet potato leaves (b) Antioxidant which is astaxanthin (c) Polysaccharide which is chitosan (d) At least one spice selected from pepper, hihatsu and black ginger (E) At least one fungus selected from lactic acid bacteria and yeast (f) At least one fermented product selected from grain fermented product and black vinegar (g) At least selected from vitamin B12, vitamin B5, vitamin B2 and vitamin B1 B vitamins (h) Plant extracts from at least one plant selected from pine bark, kudzu flower, gymnema, ginger and salasia

According to the composition for suppressing the increase in triglyceride in blood of the present invention, the effect of suppressing the increase in triglyceride in blood can be dramatically improved as compared with the case of Terminaria alone or a specific other component alone.

The composition for suppressing the increase in triglyceride in blood of the present invention is characterized by containing terminaria and at least one selected from specific other components.

[Terminaria]
The terminaria used in the composition for suppressing the increase in blood neutral fat of the present invention is not particularly limited as long as it is a plant belonging to the genus Terminaria, and for example, Terminaria bellirica, Terminaria belerica, Terminaria catappa, Terminaria tomentosa, and Termina. , Tropical almond, Tropical almond, Tropical almond, Tropical almond, Tropical almond, Tropical almond and the like. In the present invention, Terminaria bellirica is preferably used.

The processed product obtained from the terminaria used in the present invention (hereinafter, may be simply referred to as a processed product) is a dried product, paste, or squeezed product obtained from parts such as leaves, bark, roots, flowers, xylem, fruits, and seeds. Examples include juices and extracts. Any part of the terminaria of the present invention may be used, but the part excluding the seed is preferable, and the part excluding the seed of the fruit (pericarp or flesh part) is most preferably used.

The method for obtaining a dried product which is a uniform state of the processed product in the present invention is not particularly limited as long as it is dried by, for example, sun-dried, half-day-dried, shade-dried, heat-dried, room-temperature-dried, freeze-dried, or the like. If necessary, it may be pulverized using a ball mill, a hammer mill, or the like.

Further, the paste or squeezed juice, which is a uniform state of the processed product of the present invention, can be obtained by, for example, crushing the fruit of Terminaria with a mass colloider or the like without drying, and further filtering or centrifuging the paste. By separating it, it can be made into juice. It is also possible to squeeze the fruits of Terminaria into juice. Of course, the obtained extract can be used as it is, or it can be dried once to make an extract powder. Further, when the extract is obtained from the dried product, it can be obtained by adding water to the dried product and then pressing or filtering the dried product. The amount of water added is not particularly limited, but is about 1 part by mass to 50 parts by mass with respect to 1 part by mass of the dry powder.

Further, the extract which is a uniform state of the processed product of the present invention may be, for example, the fruit of Terminaria may be extracted by adding water or an organic solvent as it is, or may be extracted from a ground product, or may be extracted. , May be extracted from once dried. In particular, it is preferable to crush the fruit into a paste or dry powder before extraction.

Examples of the solvent used for extraction include water, an organic solvent, or a mixed solution of water and an organic solvent, and examples of the organic solvent include methanol, ethanol, n-propanol, n-butanol, acetone, hexane, dichloromethane, propylene glycol, and ethyl. Examples thereof include methyl ketone, glycerin, methyl acetate, ethyl acetate, diethyl ether, dichloromethane, edible oils and fats, 1,1,1,2-tetrafluoroethane, and 1,1,2-trichloroethane. It is preferably a polar organic solvent, more preferably ethanol, n-butanol, methanol, acetone, propylene glycol, ethyl acetate, and most preferably ethanol.

The amount of solvent used for extraction is not particularly limited as long as the amount of solvent is sufficiently extracted, but in the case of a dried product obtained by drying Terminaria, the amount of the solvent is 1 to 1 part by mass of the dried product. It is preferably 50 parts by mass, and when it is not a dry product, it is preferably 0.1 to 30 parts by mass. The extraction temperature is also not particularly limited and depends on the boiling point of the solvent used, but in the case of efficient extraction, the lower limit of the extraction temperature is 10 ° C or higher, preferably 20 ° C or higher, and the upper limit of the extraction temperature. The value is preferably 120 ° C. or lower, but the upper limit of the extraction temperature is preferably not higher than the boiling point of the solvent used.

The extraction time varies depending on the amount of the extraction solvent or the extraction temperature, but the lower limit of the extraction time is 30 minutes or more, preferably 1 hour or more, and the upper limit is 72 hours or less, preferably 48 hours or less. Is. In this way, the extract can be obtained from Terminaria. The obtained extract may be used as it is, but if necessary, it can be concentrated by a method usually used by those skilled in the art to obtain a liquid, paste or powdery extract. For concentration, heating dry solids, vacuum concentrated dry solids, freeze-drying and the like are used, but in order to suppress denaturation of the components in the extract, vacuum-concentrated dry solids or freeze-drying are preferable.

Furthermore, in order to make the obtained extract more active, this extract can be used as a synthetic adsorbent (Diaion HP20, Sephadex SP825, Amberlite XAD4, MCIgelCHP20P, etc.), dextran resin (Sephadex LH-20, etc.). ) Can be used to further fractionate and concentrate the components. The treated product of Terminaria thus obtained can be used in the present invention because it exhibits excellent effects.

[Other ingredients]
The composition for suppressing the increase in triglyceride in blood of the present invention is characterized by containing terminaria and a specific other component, and the specific other component has almost no ability to suppress the increase in triglyceride in blood. It is not limited as long as it is a component that can synergistically improve the ability to suppress the increase in triglyceride in blood by combining other components having a small ability with Terminaria, but is particularly described below (a) to (h). It is desirable to include at least one component selected from the group consisting of.

(A) Green leaves In the composition for suppressing the increase in triglyceride in blood of the present invention, it is preferable to use at least one kind of green leaves selected from young barley leaves and young sweet potato leaves as specific other components together with terminaria. When these other components are combined with Terminaria, not only a synergistic effect of suppressing the increase in triglyceride in blood can be obtained, but also the stimulating taste and unpleasant taste of Terminaria can be improved. In addition, the unique flavor of Terminaria can be improved, and the aroma and flavor can be made favorable. Further, it can be made to have excellent color and dispersibility as compared with the case where only Terminaria is dissolved in water.

These green leaves may be any part of the plant, but usually, parts such as leaves and stems are preferable, and the plant material itself (including dried matter), its crushed product, squeezed juice, extract, extract and the like are preferable. Can be used. Examples of the crushed product include powder, granules and the like. The squeezed juice and the extract may be liquid, but can also be used as a paste or a dry powder. The extract can be obtained by extracting with a suitable solvent, and as the solvent, for example, water, ethanol, or hydrous ethanol can be used.

The young barley leaves are first-year or perennial herbs that are native to Central Asia and belong to the Gramineae family, and are roughly classified into two-row barley and six-row barley according to the panicle shape. Not particularly limited. The young barley leaves may contain barley leaves and may contain other parts such as stems and roots in addition to the barley leaves. The young barley leaves used in the present invention are not particularly limited as long as they are usually available, and any young barley leaves such as two-row barley and six-row barley may be used. Moreover, any kind of young barley leaves may be used.

The young sweet potato leaves refer to plants belonging to the family Convolvulaceae, and are not particularly limited as long as they are generally called sweet potatoes. The sweet potato variety is not particularly limited. For example, varieties such as Suiou, Joy White, Koganesengan, Shiroyutaka, Satsu Starch, and Ayamurasaki can be mentioned. Among them, a syrup having a high polyphenol content is preferable. The sweet potato may be used as a whole or any part, but the foliage is preferable, the tip of the foliage (young foliage) is more preferable, and the young foliage that retains a yellowish green color is further preferable. preferable.

(B) Antioxidant In the composition for suppressing the increase in triglyceride in blood of the present invention, it is preferable to use an antioxidant which is astaxanthin as a specific other component together with Terminaria. When combined with Terminaria, other components can not only obtain a synergistic effect of suppressing the increase in triglyceride in blood, but also improve the pungent taste and miscellaneous taste of Terminaria. In addition, the unique flavor of Terminaria can be improved, and the aroma and flavor can be made favorable. Further, it can be made to have excellent color and dispersibility as compared with the case where only Terminaria is dissolved in water.

The astaxanthin is a kind of carotenoid, and is said to have an antioxidant effect 1000 times that of vitamin E. It may be derived from a natural product or obtained by synthesis. Examples of those derived from natural substances include astaxanthin obtained from algae such as Haematococcus algae, crustaceans such as shrimp and crab, and fish such as salmon and Thailand. Extracts and chemically synthesized products derived from natural products are commercially available, and these commercially available products can be used.

(C) Polysaccharide In the composition for suppressing the increase in triglyceride in blood of the present invention, it is preferable to use a polysaccharide which is chitosan as a specific other component together with terminaria. When combined with Terminaria, other components can not only obtain a synergistic effect of suppressing the increase in triglyceride in blood, but also improve the pungent taste and miscellaneous taste of Terminaria. In addition, the unique flavor of Terminaria can be improved, and the aroma and flavor can be made favorable. Further, it can be made to have excellent color and dispersibility as compared with the case where only Terminaria is dissolved in water.

Examples of the chitosan include those made from crustaceans such as crabs, shrimp and insects, and those made from cell walls such as mushrooms and filamentous fungi. In particular, it is preferable to use one made from crab, shrimp and the like. Examples of the method for producing chitosan or a chitosan derivative include the following methods. First, crab shells, shrimp shells and the like are crushed, and the crushed shells are treated with an acid (for example, hydrochloric acid) to perform decalcification. Next, chitin can be obtained by treating with an alkali (for example, caustic soda) to remove the protein. Further, if this is treated with an alkali (for example, caustic soda), chitosan can be obtained. Examples of the chitosan derivative include water-soluble chitosan obtained by further reducing the molecular weight of chitosan, salts thereof, and the like. Among them, those having an average molecular weight of 500,000 or more and a degree of deacetylation of 70% or more, preferably around 80 to 90% are preferable. Further, the particle size is 32 mesh or less, preferably 48 mesh or less, and 85% or more is preferable.

(D) Spices In the composition for suppressing the increase in triglyceride in blood of the present invention, it is preferable to use at least one spice selected from capsicum, long pepper and black ginger as a specific other component together with terminaria. In the present invention, it is sufficient that these components are blended, and it is not necessary to blend them for the purpose of exhibiting the functions of so-called spices such as producing aroma and pungent taste. When these other components are combined with Terminaria, not only a synergistic collagenase inhibitory action can be obtained, but also the pungent taste and unpleasant taste of Terminaria can be improved. In addition, the unique flavor of Terminaria can be improved, and the aroma and flavor can be made favorable. Further, it can be made to have excellent color and dispersibility as compared with the case where only Terminaria is dissolved in water.

These spices may be any part of the plant such as seeds, fruits, flowers, leaves, stems, roots, etc., but the parts usually used as spices are preferable, and the plant material itself (including dried products) and its parts thereof. Grinded products, squeezed juices, extracts, extracts and the like can be used. Examples of the crushed product include powder, granules and the like. The squeezed juice and the extract may be liquid, but can also be used as a paste or a dry powder. The extract can be obtained by extracting with a suitable solvent, and as the solvent, for example, water, ethanol, or hydrous ethanol can be used.

The capsicum may be any plant belonging to the genus Capsicum of the Solanaceae family, and is not particularly limited. Both varieties with pungency and varieties without pungency can be used, but it is preferable to use varieties with pungency.

The long pepper is a plant of the Piperaceae family, and its scientific name is Piper longum L. It is preferable to use the fruits of the plant.

The black ginger is a plant belonging to the genus Kaempferia of the family Zingiberaceae, and its scientific name is Kaempferia parviflora. The black ginger used in the present invention is not particularly limited, and examples thereof include Thai and Laos products, and domestic products include, for example, regardless of the production area such as domestic or foreign products. Examples include those from Okinawa. The site of the black ginger used in the present invention is not particularly limited, but it is preferable to use a rhizome.

(D) Fungi In the composition for suppressing the increase in triglyceride in blood of the present invention, it is preferable to use at least one fungus selected from lactic acid bacteria and yeast as a specific other component together with Terminaria. When these other components are combined with Terminaria, not only synergistic suppression of the increase in triglyceride in blood can be obtained, but also the pungent taste and unpleasant taste of Terminaria can be improved. In addition, the unique flavor of Terminaria can be improved, and the aroma and flavor can be made favorable. Further, it can be made to have excellent color and dispersibility as compared with the case where only Terminaria is dissolved in water.

The form of the fungus used in the present invention is not particularly limited, and a dried / powdered fungus may be used as it is, or the fungus may be used in the form of a culture obtained by culturing according to a conventional method. The substance may be used in the form of a residue obtained by subjecting the substance to a solid-liquid separation treatment such as centrifugation or filtration. In addition, dry powders and extracts of fungi are commercially available, and these commercially available products can be used.

As the lactic acid bacterium, conventionally known lactic acid bacteria can be used, but the lactic acid bacterium is not particularly limited. Such lactic acid bacteria include Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium adolescentis, Bifidobacterium mongoliense, Lactbacillus brevis, Lactbacillus gasseri, Lactobacillus acidophilus, Lactobacillus. crispatus, Lactobacillus curvatus, Lactobacillus halivaticus, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacilus paracasei, Lact
obacillus rhamnosus, Lactobacillus salivarius, Lactobacillus sporogenes, Lactobacillus sakei, Lactobacillus fructivorans, Lactobacillus hilgardii, Lactobacillus reuteri, Lactobacillus fermentum, Enterococcus faecalis ), Streptococcus thermophilus, Lactococcus lactis (sometimes referred to as Streptococcus lactis), Leuconostoc mesenteroides, Leuconostoc oenos, Pediococcus acidilactici, Pediococcus pentosaceus, Staphylococcus carnosus, Staphylococcus , Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, Lactbacillus gasseri, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum, Lactobacilus paracasei, Lactobacillus plantarum, Lactobacillus fermentum, Lactobacillus , Lactococcus lactis (Streptococcus) lactis), Bacillus coagulans, Bacillus mesentericus are preferred. The properties of these lactic acid bacteria are not particularly limited, and can be appropriately selected depending on the dosage form and quality of the composition for suppressing the increase in triglyceride in blood of the present invention. Examples include sugar resistance, salt resistance, and spore resistance. The method for obtaining lactic acid bacteria is not particularly limited, and for example, lactic acid bacteria isolated from foods such as yogurt and vegetables or commercially available products may be used.

As the yeast, conventionally known yeasts can be used, but the yeast is not particularly limited. Such yeasts include Saccharomyces such as Saccharomyces cerevisiae, Candida lipolytica such as Candida lipolytica, Candida genus Candida, toluspora trebula, and so on. The genus Torulaspora, the genus Kluyveromyces such as Kluyveromyces thermotolerans, the genus Pichia membranefaciens (the genus Pichia membranefacies) belongs to the genus Pichia, etc. , Preferably the genus Saccharomyces.

(E) Fermented product In the composition for suppressing the increase in triglyceride in blood of the present invention, it is preferable to use at least one fermented product selected from a fermented grain product and black vinegar as a specific other component together with Terminaria. When these other components are combined with Terminaria, not only a synergistic effect of suppressing the increase in triglyceride in blood can be obtained, but also the stimulating taste and unpleasant taste of Terminaria can be improved. In addition, the unique flavor of Terminaria can be improved, and the aroma and flavor can be made favorable. Further, it can be made to have excellent color and dispersibility as compared with the case where only Terminaria is dissolved in water.

These fermented products are not particularly limited, but the fermented products may be used as they are, or the fermented products may be dried and crushed. Further, it may be extracted from a fermented product, and the extract can be used as it is by pulverizing it. Examples of the crushed product include powder, granules and the like. The extract may be liquid, but it can also be used as a paste or a dry powder. The extract can be obtained by extracting with a suitable solvent, and as the solvent, for example, water, ethanol, or hydrous ethanol can be used.

As the fermented grain product, a product obtained by fermenting the seeds of a gramineous plant or a legume can be used, but is not particularly limited. Examples of grass seeds include rice, corn, barley, wheat, limewood, crow wheat, bean, pearl barley, millet, awa, Japanese millet, and morokoshi, and legume seeds include soybean, adzuki bean, and mung bean. Examples include pearl barley, green bean, red bean, pea, soramame, lens bean, chick bean, lens bean, and sword bean. For fermentation, any part of the seed such as whole grain, pericarp, seed coat, endosperm, cotyledon, hypocotyl, etc. may be used, but it is usually preferable to use the bran produced when the grain is refined. As the bacterial cells used for fermentation, bacterial cells usually used for fermentation such as aspergillus, yeast, lactic acid bacteria, acetic acid bacteria, and bacillus bacillus can be used, and even if only one bacterial cell is used in the present invention, There may be two or more types. In the present invention, since grains can be decomposed by various enzymes, it is particularly preferable to use Jiuqu.

As the black vinegar, rice alone, barley or wheat added to rice, or barley alone fermented as a raw material and turned brown or dark brown by fermentation or aging can be used, but is not particularly limited. The grain used for fermentation may be unrefined, but may be refined. As the bacterial cells used for fermentation, bacterial cells usually used for fermentation such as aspergillus, yeast, lactic acid bacteria, acetobacter, Bacillus subtilis, etc. can be used, but since grains can be decomposed by various enzymes, aspergillus is particularly effective. It is preferable to use.

(G) Vitamin B group In the composition for suppressing the increase in neutral fat in blood of the present invention, at least the B vitamin group selected from vitamin B12, vitamin B5, vitamin B2 and vitamin B1 is used as a specific other component together with terminaria. Is preferable. When these other components are combined with Terminaria, not only a synergistic effect of suppressing the increase in triglyceride in blood can be obtained, but also the stimulating taste and unpleasant taste of Terminaria can be improved. In addition, the unique flavor of Terminaria can be improved, and the aroma and flavor can be made favorable. Further, it can be made to have excellent color and dispersibility as compared with the case where only Terminaria is dissolved in water.

(H) Plant extract In the composition for suppressing the increase in triglyceride in blood of the present invention, at least one plant selected from pine bark, kudzu flower, gymnema, ginger and Salacia as specific other components together with terminaria. It is preferable to use a plant extract extracted from. When these other components are combined with Terminaria, not only a synergistic effect of suppressing the increase in triglyceride in blood can be obtained, but also the stimulating taste and unpleasant taste of Terminaria can be improved. In addition, the unique flavor of Terminaria can be improved, and the aroma and flavor can be made favorable. Further, it can be made to have excellent color and dispersibility as compared with the case where only Terminaria is dissolved in water.

Examples of the pine bark extract include extracts of bark of French coastal pine (Pinus Martinma), Japanese black pine, Japanese black pine, red pine and the like, and among these, French coastal pine (Pinus Martina) containing abundant proanthocyanidins. ) Bark extract is preferred.

As the kudzu flower, a flower of a plant belonging to the genus Kudzu of the leguminous family is used. Kuzu is a climbing perennial plant of the genus Pueraria montana in the family Leguminosae. As the site used as the plant material of the present invention, flowers and roots are preferable, and flowers are particularly preferable. As the kudzu flower, the one collected in any process from the bud to the fully opened flower may be used, or the one collected in each process may be mixed and used. The type of kudzu is not particularly limited, and examples thereof include Pueraria homsonii, Pueraria lobata, and Pueraria sumbergiana.

As the gymnema, gymnema is a vine belonging to the Apocynaceae family native to India and Sri Lanka, and examples thereof include Gymnema sylvestre. Stems and leaves are preferable as the sites used in the present invention.

The ginger is not particularly limited as long as it is a plant of the family Ginger, and for example, Sanshu ginger, Omi ginger, Tananaka ginger, Kintoki ginger, Shizuoka No. 4, yellow ginger, earth ginger, otafuku ginger and the like. Various ginger can be mentioned. As the form of the ginger family plant raw material used in the present invention, the rhizome can be used as it is, or it can be used as a slice, a crushed product, a juice, a grated product, an extract or the like. Examples of the crushed product include powder, granules and the like. The squeezed juice and the extract may be liquid, but can also be used as a paste or a dry powder. The extract can be obtained by extracting with a suitable solvent, and as the solvent, for example, water, ethanol, or hydrous ethanol can be used. The solvent used is not particularly limited, but it is preferable to use a solution containing ethanol. For example, an extract can be obtained by adding ethanol or hydrous ethanol to a finely divided rhizome of a ginger family plant.

The Salacia is a plant belonging to the genus Salacia of the family Salacia, which grows mainly in Sri Lanka, India and Southeast Asia. Salacia reticularata is particularly preferred. Roots are preferred as the site used in the present invention.

[Composition for suppressing increase in triglyceride in blood]
The composition for suppressing the increase in triglyceride in blood of the present invention is preferably a food for suppressing the increase in triglyceride in blood, which is used for suppressing the increase in triglyceride in blood. The food for use is not particularly limited as long as it contains Terminaria and specific other materials and can be distinguished from other products in that it is used for suppressing the increase in triglyceride in blood. For example, the scope of the present invention includes an indication that any of the main body, packaging, instruction manual, and advertised material of the product according to the present invention has a function of suppressing the increase in triglyceride in blood. For example, so-called health foods such as functional foods whose efficacy has been approved by a predetermined organization such as foods for specified health use and foods with functional claims can be mentioned. Specifically, "neutral fat level in blood" can be mentioned. "Reduce (reduce, lower) triglyceride", "Suppress the rise of triglyceride in the blood", "Suppress the triglyceride rise after meals", "Slow the rise of triglyceride in the blood after meals", Examples of those displaying "suppressing the absorption of fat in the diet", "helping the health of those with high triglyceride", etc. can be exemplified.

Examples of the form of the composition for suppressing the increase in triglyceride in blood of the present invention include liquid, powder, granule, tablet, capsule, granule, rod, plate, block, solid, and round. Examples thereof include paste, cream, capsule, gel, chewable, and stick. Among these, liquid, powdery, and granular forms are particularly preferable. Specific examples thereof include bottled beverages filled in PET bottles, cans, bottles, etc., and instant powdered beverages or instant granule beverages to be dissolved in water (hot water), milk, fruit juice, green juice, etc. and drunk. be able to. These are preferable in that they are easy to drink at the time of meals and can enhance the palatability.

The compounding mass ratio of the terminaria and the specific other material is preferably in the range of 0.5: 1 to 80: 1, and preferably in the range of 0.75: 1 to 70: 1 in terms of dry mass. It is more preferably in the range of 1: 1 to 60: 1, and particularly preferably in the range of 1: 1 to 50: 1. When the blending ratio of the terminaria and the specific other material is within the above range, the effect of the present invention can be more effectively exhibited.

The content of terminaria and a specific other material in the composition for suppressing the increase in triglyceride in blood of the present invention may be appropriately contained within the range in which the effect is exhibited, and terminaria is used as an active ingredient, and (a) to It may contain at least one component selected from the group consisting of (h), or may contain at least one component selected from the group consisting of terminaria and (a) to (h) as an active ingredient. good. When terminaria is used as an active ingredient and at least one component selected from the group consisting of (a) to (h) is contained, a specific other component may be contained as an accelerator for the action of terminaria. .. In general, the content thereof is preferably 0.01 to 100% by mass, and 0.1 to 97% by mass, in terms of dry mass, that is, Terminaria and a specific other material. More preferably, it is more preferably contained in an amount of 0.5 to 95% by mass.

When the composition for suppressing the increase in triglyceride in blood of the present invention is a tablet or a capsule, it contains 0.01 to 100% by mass of terminaria and specific other materials in terms of dry mass. Is more preferable, 0.1 to 90% by mass is more preferable, and 0.5 to 80% by mass is further preferable.

When the composition for suppressing the increase in triglyceride in blood of the present invention is an instant powdered beverage or an instant granule beverage, it contains 1 to 100% by mass of terminaria and specific other materials in terms of dry mass. It is preferable that it is contained in an amount of 3 to 90% by mass, and even more preferably it is contained in an amount of 5 to 80% by mass.

When the composition for suppressing the increase in triglyceride in blood of the present invention is a packaged beverage, it may contain 0.1 to 10% by mass of terminaria and specific other materials in terms of dry mass. It is preferably contained in an amount of 0.3 to 6% by mass, more preferably 0.5 to 4% by mass.

The intake amount of the composition for suppressing the increase in triglyceride in blood of the present invention is not particularly limited, but from the viewpoint of exerting the effect of the present invention more remarkably, the terminaria per meal and specific other materials may be used. It is preferable to take it so that the intake amount is 50 mg / dose or more, more preferably 100 mg / dose or more, further preferably 150 mg / dose or more, and 200 mg / dose. It is particularly preferable to take it at least once. The food having the effect of suppressing the increase in triglyceride in blood of the present invention is one container or one day's worth, or, for example, two or three or more so that one intake is the above-mentioned intake. It can be divided into containers and stored as one day's worth. For example, the instant powdered beverage or the instant granule beverage can be packaged in an amount of 3 to 10 g each.

In addition, the composition for suppressing the increase in triglyceride in blood of the present invention may contain components other than Terminaria and specific other materials, if necessary. Ingredients other than Terminaria and certain other materials include, for example, water-soluble vitamins (vitamins B1, B2, B3, B5, B6, B12, B13, B15, B17, biotin, choline, folic acid, inositol, PABA, vitamin C, etc. Vitamins such as vitamin P) and oil-soluble vitamins (vitamins A, D, E, K); minerals such as calcium, magnesium, phosphorus and iron; sulfur-containing compounds contained in taurine, garlic and the like; hesperidin, kelcetin and the like Flavanoids or flavonoids; Proteins such as collagen; Peptides; Amino acids; Animal fats and oils; Vegetable fats and oils; Crushes or extracts of animals and plants, calcium stearate, silicon dioxide, sucrose fatty acid esters, glycerin fatty acid esters, malt sugar, reductions Examples thereof include excipients such as malt sugar, reduced palatinose, cellulose, and hydroxypropyl cellulose.

In addition, examples of the composition for suppressing the increase in triglyceride in blood of the present invention include foods to which Terminaria and specific other materials are added. Such foods include, for example, carbonated beverages, nutritional beverages, fruit beverages, lactic acid beverages, green juice and other beverages; cold confectionery such as ice cream, ice sherbet, and shaved ice; noodles such as buckwheat noodles, udon noodles, harusame, Chinese noodles, and instant noodles. Confectionery such as candy, candy, gum, chocolate, tablet confectionery, snack confectionery, biscuits, jelly, jam, cream, baked confectionery, bread; Dairy products such as yogurt; oils and fats such as salad oil, tempura oil, margarine, mayonnaise, shortening, whipped cream, dressing and their processed foods; seasonings such as sauces and soy sauce; curry, stew, parent and child bowl, porridge, miscellaneous dishes, Chinese Retort pouch foods such as bowls, katsudon, tempura bowls, beef bowls, hayashi rice, omelet rice, oden, marbo dough, dumplings, shumai, hamburgers, meat balls, various sauces, and various soups can be mentioned. The properties, blending amount, intake amount, other components, etc. of Terminaria and specific other materials are the same as described above.

Hereinafter, the present invention will be described based on examples.
[Example 1] Lipase inhibition test Each test substance suspension was formulated with a Terminaria-treated product and specific other components in an Eppendorf tube using 0.1 M PBS as a solvent as follows. For Terminaria, a dried powder of a hot water extract of the pulp of Terminaria berylica was used. For the young barley leaves, "barley young leaf powder" manufactured by Toyo Shinyaku was used. For the sweet potato young leaves, "sweet potato young leaf powder" manufactured by Toyo Shinyaku was used.
Astaxanthin was a commercially available synthetic product. As chitosan, a commercially available one was used. As the capsicum, a commercially available powder of capsicum was used. For long peppers, commercially available dry powder of fruit ears was used. As the black ginger, a dry powder of an ethanol extract of the rhizome of black ginger (Kaempferia parviflora) was used. As the lactic acid bacterium, a commercially available human intestinal-derived Escherichia coli Enterococcus faecalis (killed bacterium) was used. As the yeast, commercially available dried brewer's yeast powder (killed bacteria) with reduced bitterness was used. As the fermented grain product, a commercially available fermented wheat bran extract powder was used. As the black vinegar, a commercially available black vinegar extract was used. As the vitamins, all commercially available vitamins were used, and as vitamin B1, hydrochloride was used. For the pine bark, "flavangenol" manufactured by Toyo Shinyaku was used. For the kudzu flower, "Kuzunohana extract" manufactured by Toyo Shinyaku was used. For Gymnema, an extract powder extracted from the leaves of commercially available Gymnema sylvestre was used. As ginger, commercially available ginger extract powder was used. For Salacia, a commercially available Salacia reticulata root extract powder was used.

5 μL of 0.08 mg / mL lipase, 4 μL of elastase inhibitor, and 200 μL of color-developing solution were added to each of the blended sample solutions, and preincubated at 30 ± 1 ° C. for 5 minutes in the dark. After adding 20 μL of the substrate solution and incubating at 30 ± 1 ° C. for 30 minutes, 400 μL of the stop solution was added. For the blank, the substrate solution was added after the reaction stop solution was added. 300 μL of the reaction solution was transferred to a 96-well plate, and the absorbance at 412 nm was measured with a microplate reader. Using the measured absorbance, the lipase inhibition rate was calculated by the following formula.
Inhibition rate (% of control) = (1-[(Sample ^test -Sample ^blank ) / Control ^test -Control ^blank ]]) x 100

Table 2 shows the results of the lipase inhibition test measured in Example 1. Numerical values other than the inhibition rate in Table 2 indicate the final concentration of the sample, and the inhibition rate indicates the relative inhibition rate of each group when the inhibition rate of the terminaria-treated product alone group is 100%.

As shown in Table 2, it can be seen that the lipase inhibitory action is dramatically improved by combining Terminaria even when the lipase inhibitory action of the specific other component itself is considerably low. Since the combination of the terminaria-treated product of the present invention and a specific other material has an excellent lipase inhibitory effect, by inhibiting lipase, it is possible to suppress the decomposition of fat in the digestive tract and suppress the absorption of fat from the intestinal tract. Be expected.

(Comparative Examples 22 to 23)
For the morus alba powder (Comparative Example 22) and vitamin B6 (Comparative Example 23), the same test as in Example 1 was performed, and the change value of the terminaria and the change value of either the morus alba powder or vitamin B6 were totaled. Occasionally, the change value of the combination test group was less than 1.2 times, and no lipase inhibitory effect was confirmed.

Since the food of the present invention has an effect of suppressing an increase in triglyceride in blood, it is highly industrially useful.

Claims (1)

An oral composition for suppressing an increase in neutral fat, which comprises a terminaria -treated product as an active ingredient and further contains at least one fungus selected from Enterococcus faecalis and brewer 's yeast, wherein the terminaria-treated product is contained. Is an oral composition characterized in that it is a dried product, paste, squeezed juice and / or extract obtained from the parts of Terminaria leaves, bark, roots, flowers, xylem, fruits and / or seeds .