JP7032394B2 - 抗ｉｌ１－ｒａｐ抗体 - Google Patents

抗ｉｌ１－ｒａｐ抗体 Download PDF

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JP7032394B2
JP7032394B2 JP2019520368A JP2019520368A JP7032394B2 JP 7032394 B2 JP7032394 B2 JP 7032394B2 JP 2019520368 A JP2019520368 A JP 2019520368A JP 2019520368 A JP2019520368 A JP 2019520368A JP 7032394 B2 JP7032394 B2 JP 7032394B2
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antibody
sequence
rap
chain variable
variable region
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Japanese (ja)
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JP2019534705A (ja
JP2019534705A5 (show.php
Inventor
インピン チャン
ジャガット アール． ジュヌトゥラ
レオナール ジー． プレスタ
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カンタージア アクチエボラーグ
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Priority claimed from PCT/US2017/055994 external-priority patent/WO2018071455A1/en
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Priority claimed from PCT/US2017/056808 external-priority patent/WO2018071910A2/en
Publication of JP2019534705A publication Critical patent/JP2019534705A/ja
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Priority to JP2022026299A priority Critical patent/JP7235904B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2019520368A 2016-10-16 2017-10-16 抗ｉｌ１－ｒａｐ抗体 Active JP7032394B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022026299A JP7235904B2 (ja) 2016-10-16 2022-02-24 抗ｉｌ１－ｒａｐ抗体

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662408807P 2016-10-16 2016-10-16
US62/408,807 2016-10-16
US201662425970P 2016-11-23 2016-11-23
US62/425,970 2016-11-23
USPCT/US2017/055994 2017-10-10
PCT/US2017/055994 WO2018071455A1 (en) 2016-10-10 2017-10-10 Isoquinolidinobenzodiazepine (iqb)-1(chloromethyl)-2,3-dihydro-1h-benzo[e]indole (cbi) dimers
PCT/US2017/056808 WO2018071910A2 (en) 2016-10-16 2017-10-16 Anti-il1-rap antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022026299A Division JP7235904B2 (ja) 2016-10-16 2022-02-24 抗ｉｌ１－ｒａｐ抗体

Publications (3)

Publication Number Publication Date
JP2019534705A JP2019534705A (ja) 2019-12-05
JP2019534705A5 JP2019534705A5 (show.php) 2020-11-26
JP7032394B2 true JP7032394B2 (ja) 2022-03-30

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JP2019520368A Active JP7032394B2 (ja) 2016-10-16 2017-10-16 抗ｉｌ１－ｒａｐ抗体
JP2022026299A Active JP7235904B2 (ja) 2016-10-16 2022-02-24 抗ｉｌ１－ｒａｐ抗体

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JP2022026299A Active JP7235904B2 (ja) 2016-10-16 2022-02-24 抗ｉｌ１－ｒａｐ抗体

Country Status (6)

Country Link
US (1) US11359025B2 (show.php)
EP (1) EP3526247A4 (show.php)
JP (2) JP7032394B2 (show.php)
CN (1) CN110036028B (show.php)
AU (1) AU2017343784A1 (show.php)
CA (1) CA3084459A1 (show.php)

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GB2472856B (en) 2009-08-21 2012-07-11 Cantargia Ab IL1-RAP modulators and uses thereof
CA2824719C (en) 2011-01-19 2020-06-02 Cantargia Ab Anti-il1rap antibodies and their use for treating solid tumours
GB201403875D0 (en) 2014-03-05 2014-04-16 Cantargia Ab Novel antibodies and uses thereof
CN112638946A (zh) 2018-08-16 2021-04-09 坎塔吉亚有限责任公司 抗il1rap抗体组合物
CN114599678A (zh) 2019-08-12 2022-06-07 希望之城 Il1rap抗体
US11479610B2 (en) * 2020-12-23 2022-10-25 Cantargia Ab Anti-IL1RAP antibody
EP4288457A2 (en) * 2021-02-05 2023-12-13 Boehringer Ingelheim International GmbH Anti-il1rap antibodies
CN117043866A (zh) 2021-02-08 2023-11-10 Cdx医疗Ip公司 按照细胞和组织的诊断重要性顺序动态优先处理、组织和显示细胞和组织
EP4453027A4 (en) * 2021-12-23 2025-11-19 Novavax Inc SARS-CoV-2 Anti-Spicule Antibodies and Their Use in the Treatment of COVID-19
CN120603854A (zh) * 2022-12-29 2025-09-05 财团法人生物技术开发中心 跨膜和盘绕结构域家族3的特异性抗体及其用途
AU2024216919A1 (en) * 2023-02-09 2025-08-07 City Of Hope Anti-il1rap antibodies and variants thereof
WO2025024431A1 (en) * 2023-07-24 2025-01-30 Vanderbilt University Broadly reactive antibodies to influenza b viruses
WO2025126157A1 (en) * 2023-12-15 2025-06-19 Advesya Anti-il-1rap binding domains and antibody-drug conjugates thereof

Citations (3)

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JP2014511348A (ja) 2011-01-19 2014-05-15 カンタージア アクチエボラーグ 抗ｉｌ−１ｒａｐ抗体及びヒトを処置するためのそれらの使用
WO2015132602A1 (en) 2014-03-05 2015-09-11 Cantargia Ab Anti human interleukin-1 receptor accessory protein (il1 rap) antibodies and uses thereof
WO2016020502A1 (en) 2014-08-06 2016-02-11 Cantargia Ab Novel antibodies and uses thereof

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US6417324B1 (en) 2000-04-21 2002-07-09 Tripep Ab Synthetic peptides that bind to the hepatitis B virus core and e antigens
US20030007976A1 (en) 1997-12-23 2003-01-09 Watson James D. Methods and compounds for the treatment of immunologically-mediated skin disorders
US8293883B2 (en) 2007-02-23 2012-10-23 Schering Corporation Engineered anti-IL-23P19 antibodies
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JP2014511348A (ja) 2011-01-19 2014-05-15 カンタージア アクチエボラーグ 抗ｉｌ−１ｒａｐ抗体及びヒトを処置するためのそれらの使用
WO2015132602A1 (en) 2014-03-05 2015-09-11 Cantargia Ab Anti human interleukin-1 receptor accessory protein (il1 rap) antibodies and uses thereof
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Agerstam, H. et al.，"Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia"，Proc. Natl. Acad. Sci. U. S. A.，2015年，Vol. 112，pp. 10786-10791
Askmyr, M. et al.，"Selective killing of candidate AML stem cells by antibody targeting of IL1RAP"，Blood，2013年，Vol. 121，pp. 3709-3713, Supplemental data

Also Published As

Publication number Publication date
JP2022091747A (ja) 2022-06-21
US20190338038A1 (en) 2019-11-07
JP7235904B2 (ja) 2023-03-08
EP3526247A4 (en) 2021-04-14
JP2019534705A (ja) 2019-12-05
US11359025B2 (en) 2022-06-14
CN110036028B (zh) 2023-09-08
AU2017343784A1 (en) 2019-08-29
CN110036028A (zh) 2019-07-19
EP3526247A2 (en) 2019-08-21
CA3084459A1 (en) 2018-04-19

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