JP7027437B2 - ＲＯＲ－γモジュレーター - Google Patents

ＲＯＲ－γモジュレーター Download PDF

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Publication number
JP7027437B2
JP7027437B2 JP2019544789A JP2019544789A JP7027437B2 JP 7027437 B2 JP7027437 B2 JP 7027437B2 JP 2019544789 A JP2019544789 A JP 2019544789A JP 2019544789 A JP2019544789 A JP 2019544789A JP 7027437 B2 JP7027437 B2 JP 7027437B2
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formula
compounds
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compound
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Japanese (ja)
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JP2019535813A (ja
JP2019535813A5 (https=
Inventor
ナス，ジョン
ハリス，ジェイソン
モハン，ラジュ
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エスカリア バイオサイエンシーズ，ビーブイ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Processing Of Color Television Signals (AREA)
  • Picture Signal Circuits (AREA)
  • Details Of Television Scanning (AREA)
JP2019544789A 2016-10-27 2017-10-27 ＲＯＲ－γモジュレーター Expired - Fee Related JP7027437B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662413907P 2016-10-27 2016-10-27
US62/413,907 2016-10-27
PCT/US2017/058755 WO2018081558A1 (en) 2016-10-27 2017-10-27 Ror-gamma modulators

Publications (3)

Publication Number Publication Date
JP2019535813A JP2019535813A (ja) 2019-12-12
JP2019535813A5 JP2019535813A5 (https=) 2020-12-03
JP7027437B2 true JP7027437B2 (ja) 2022-03-01

Family

ID=62024021

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019544789A Expired - Fee Related JP7027437B2 (ja) 2016-10-27 2017-10-27 ＲＯＲ－γモジュレーター

Country Status (14)

Country Link
US (5) US10905687B2 (https=)
EP (1) EP3532062B1 (https=)
JP (1) JP7027437B2 (https=)
KR (1) KR102598775B1 (https=)
CN (1) CN110139652B (https=)
AU (1) AU2017348345B2 (https=)
BR (1) BR112019008548A2 (https=)
CA (1) CA3042080A1 (https=)
ES (1) ES2928904T3 (https=)
IL (1) IL266261B (https=)
MX (1) MX392163B (https=)
PH (1) PH12019500949A1 (https=)
RU (1) RU2753490C2 (https=)
WO (1) WO2018081558A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112019008548A2 (pt) 2016-10-27 2019-09-17 Escalier Biosciences Bv moduladores ror-gama
JP2021517563A (ja) 2018-03-12 2021-07-26 エスカリア バイオサイエンシーズ，ビーブイ 二環式ＲＯＲγモジュレーター
KR20210060367A (ko) 2018-03-12 2021-05-26 에스칼리에 바이오사이언시스, 비브이 스피로사이클릭 ror-감마 조절제
EP4054712A2 (en) * 2019-11-05 2022-09-14 Dermira, Inc Ror gamma t inhibitors and topical uses thereof
CA3186628A1 (en) * 2020-06-30 2022-01-06 Dermira, Inc. Ror.gamma.t inhibitors and topical uses thereof
CN111892599B (zh) * 2020-08-14 2023-01-13 黄芳 一种2,5-二氮杂双环[2.2.2]辛烷-2-羧酸叔丁酯的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011520837A (ja) 2008-05-15 2011-07-21 ナームローゼ・フエンノートチヤツプ・オルガノン Ｎ−（１，１，１，３，３，３−ヘキサフルオロ−２−ヒドロキシプロパン−２−イル）ベンジル−ｎ’−アリールカルボニルピペラジン誘導体
US20140187554A1 (en) 2011-05-16 2014-07-03 The Scripps Research Institute Modulators of the nuclear hormone receptor ror
JP2015522057A (ja) 2012-07-11 2015-08-03 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ＲＯＲｃモジュレーターとしてのアリールスルタム誘導体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6432957B1 (en) 2001-06-29 2002-08-13 Kowa Co., Ltd. Piperazine derivative
AU2003280558A1 (en) 2002-10-11 2004-05-04 Kowa Co., Ltd. Method for treatment of cancer
HUP1100166A2 (en) * 2011-03-29 2012-12-28 Sanofi Sa Reductive amination process for preparation of dronedarone using amine intermediary compound
BR112014003704A2 (pt) * 2011-09-19 2017-03-07 Eth Zuerich moduladores ror gama
WO2016145298A1 (en) * 2015-03-12 2016-09-15 The Regents Of The University Of California METHODS FOR TREATING CANCER WITH RORgamma INHIBITORS
BR112019008548A2 (pt) 2016-10-27 2019-09-17 Escalier Biosciences Bv moduladores ror-gama

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011520837A (ja) 2008-05-15 2011-07-21 ナームローゼ・フエンノートチヤツプ・オルガノン Ｎ−（１，１，１，３，３，３−ヘキサフルオロ−２−ヒドロキシプロパン−２−イル）ベンジル−ｎ’−アリールカルボニルピペラジン誘導体
US20140187554A1 (en) 2011-05-16 2014-07-03 The Scripps Research Institute Modulators of the nuclear hormone receptor ror
JP2015522057A (ja) 2012-07-11 2015-08-03 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ＲＯＲｃモジュレーターとしてのアリールスルタム誘導体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Xue, Xiao-xian; Zhang, Yan; Xu, Yong; Song, Hong-rui，Synthesis and preliminary bioactivities evaluation of retinoic acid-related orphan receptor γ inhibitors，Zhongguo Yaowu Huaxue Zazhi ，2014年，24(4),，279-285

Also Published As

Publication number Publication date
EP3532062A1 (en) 2019-09-04
US20230277527A1 (en) 2023-09-07
US20220175765A1 (en) 2022-06-09
AU2017348345B2 (en) 2022-01-27
WO2018081558A1 (en) 2018-05-03
US20190269674A1 (en) 2019-09-05
CN110139652B (zh) 2022-10-11
PH12019500949A1 (en) 2019-08-05
EP3532062B1 (en) 2022-07-20
KR20190096979A (ko) 2019-08-20
US20210069182A1 (en) 2021-03-11
JP2019535813A (ja) 2019-12-12
CN110139652A (zh) 2019-08-16
ES2928904T3 (es) 2022-11-23
KR102598775B1 (ko) 2023-11-03
MX2019004973A (es) 2019-09-19
EP3532062A4 (en) 2020-04-15
AU2017348345A1 (en) 2019-05-30
IL266261B (en) 2022-07-01
MX392163B (es) 2025-03-21
RU2753490C2 (ru) 2021-08-17
RU2019115059A (ru) 2020-11-27
RU2019115059A3 (https=) 2020-12-18
IL266261A (en) 2019-06-30
CA3042080A1 (en) 2018-05-03
US10905687B2 (en) 2021-02-02
US20240216361A1 (en) 2024-07-04
BR112019008548A2 (pt) 2019-09-17

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