JP7026263B2 - 抗腫瘍の漢方薬組成物及びその揮発性油エキス - Google Patents
抗腫瘍の漢方薬組成物及びその揮発性油エキス Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Claims (9)
- 重量部でチョウジ5部、シュクシャ5部、トウシキミ3部、ニッケイ8部、シロコショウ3部、モッコウ3部、及びショウキョウ5部から構成されることを特徴とする抗腫瘍用漢方薬組成物。
- チョウジ5部、シュクシャ5部、トウシキミ3部、ニッケイ8部、シロコショウ3部、モッコウ3部、及びショウキョウ5部から構成される漢方薬の揮発性油エキスを用いる抗腫瘍薬の生産方法であって、該漢方薬の揮発性油エキスの調製方法は、前記した割合のチョウジ、シュクシャ、トウシキミ、ニッケイ、シロコショウ、モッコウ及びショウキョウの混合物に蒸留水を加え、水蒸気蒸留法により抽出し、揮発性油エキスの粗製品を得、前記の揮発性油エキス粗製品を有機溶剤で抽出し、得られた有機相を溶剤揮発させ、脱水・乾燥することにより、漢方薬の揮発性油エキスを得ることを特徴とする生産方法。
- 前記の漢方薬の揮発性油エキスは、オイゲノール42.43~59.19%、オイゲノールアセテート13.05~15.28%、p-アリルアニソール10.02~13.11%、カリオフィレン2.07~2.88%、ボルニルアセテート1.3~1.71%を含むことを特徴とする請求項2に記載の生産方法。
- 前記の漢方薬の揮発性油エキスの密度は、1.0~1.1g/mLであることを特徴とする請求項3に記載の生産方法。
- 請求項1に記載の抗腫瘍用漢方薬組成物を含む、抗腫瘍薬。
- 前記の腫瘍は、rasプロトオンコジーンが突然変異した後の過剰表現によるものであることを特徴とする請求項5に記載の抗腫瘍薬。
- 前記の腫瘍は、肝臓がん、膵臓がん、肺がん、及び結腸がんであることを特徴とする請求項6に記載の抗腫瘍薬。
- 前記の腫瘍は、rasプロトオンコジーンが突然変異した後の過剰表現によるものであることを特徴とする請求項2に記載の生産方法。
- 前記の腫瘍は、肝臓がん、膵臓がん、肺がん、及び結腸がんであることを特徴とする請求項8に記載の生産方法。
Applications Claiming Priority (3)
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CN201910045120.6 | 2019-01-17 | ||
CN201910045120.6A CN109512995B (zh) | 2019-01-17 | 2019-01-17 | 一种抗肿瘤中药组合物及其挥发油提取物 |
PCT/CN2019/095410 WO2020147275A1 (zh) | 2019-01-17 | 2019-07-10 | 一种抗肿瘤中药组合物及其挥发油提取物 |
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JP2021526544A JP2021526544A (ja) | 2021-10-07 |
JP7026263B2 true JP7026263B2 (ja) | 2022-02-25 |
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CN (1) | CN109512995B (ja) |
WO (1) | WO2020147275A1 (ja) |
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CN111437367A (zh) * | 2019-01-17 | 2020-07-24 | 兰州大学 | 一种中药组合物水提物在抑制ras原癌基因过表达肿瘤药物中的应用 |
CN109512995B (zh) * | 2019-01-17 | 2021-11-12 | 上海中华药业有限公司 | 一种抗肿瘤中药组合物及其挥发油提取物 |
Citations (2)
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JP2000514033A (ja) | 1995-03-23 | 2000-10-24 | 湧川 張 | 消化性潰瘍を処置するための漢方薬組成物およびその調製 |
CN108421017A (zh) | 2018-05-09 | 2018-08-21 | 上海中华药业有限公司 | 龙虎人丹在制备降血脂和动脉斑块药物中的应用 |
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CN101637607B (zh) * | 2009-08-25 | 2012-02-15 | 上海中华药业有限公司 | 一种龙虎人丹植物药组合物及其制备和应用 |
KR101545507B1 (ko) * | 2013-09-30 | 2015-08-19 | 서울대학교산학협력단 | 가중나무 추출물을 유효성분으로 하는 암질환의 치료 또는 예방용 조성물 |
CN104931592A (zh) * | 2014-03-19 | 2015-09-23 | 上海中华药业有限公司 | 一种龙虎人丹植物药中的14种不挥发性成分的含量检测方法 |
CN104950045A (zh) * | 2014-03-27 | 2015-09-30 | 上海中华药业有限公司 | 一种龙虎人丹植物药中的6种挥发性成分的含量检测方法 |
CN105004799B (zh) * | 2014-04-23 | 2017-07-18 | 上海中华药业有限公司 | 一种龙虎人丹植物药血浆中的8种不挥发性成分的含量检测方法 |
CN108066345A (zh) * | 2016-11-14 | 2018-05-25 | 武汉华杰世纪生物医药有限公司 | 一种具有抗肿瘤作用的化合物 |
CN109529005B (zh) * | 2019-01-17 | 2021-12-10 | 上海中华药业有限公司 | 人丹用于治疗ras原癌基因过表达肿瘤的新用途 |
CN109512995B (zh) * | 2019-01-17 | 2021-11-12 | 上海中华药业有限公司 | 一种抗肿瘤中药组合物及其挥发油提取物 |
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Patent Citations (2)
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JP2000514033A (ja) | 1995-03-23 | 2000-10-24 | 湧川 張 | 消化性潰瘍を処置するための漢方薬組成物およびその調製 |
CN108421017A (zh) | 2018-05-09 | 2018-08-21 | 上海中华药业有限公司 | 龙虎人丹在制备降血脂和动脉斑块药物中的应用 |
Non-Patent Citations (7)
Title |
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三星実母散 添付文書(三星製薬株式会社),2012年11月 |
上海科学技術出版社,中薬大辞典,第二巻初版第三刷,株式会社小学館,1998年,pp. 834-837, 1134-1139, 1206-1211 |
實母散 添付文書(株式会社日参製薬保寿堂),2013年08月 |
日本東洋醫學會誌,1953年,Vol. 4, No. 2,pp. 23-26 |
生薬単(ショウヤクタン),改訂第3版第1刷,丸善雄松堂株式会社,2017年,pp. 346-351 |
薬学雑誌,1972年,Vol. 92, No. 3,pp. 328-332 |
薬理と臨床,2009年,Vol. 19, No. 4,pp. 279-305 |
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CN109512995A (zh) | 2019-03-26 |
WO2020147275A1 (zh) | 2020-07-23 |
CN109512995B (zh) | 2021-11-12 |
JP2021526544A (ja) | 2021-10-07 |
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