JP7023371B2 - 胆汁うっ滞性そう痒の処置 - Google Patents
胆汁うっ滞性そう痒の処置 Download PDFInfo
- Publication number
- JP7023371B2 JP7023371B2 JP2020538758A JP2020538758A JP7023371B2 JP 7023371 B2 JP7023371 B2 JP 7023371B2 JP 2020538758 A JP2020538758 A JP 2020538758A JP 2020538758 A JP2020538758 A JP 2020538758A JP 7023371 B2 JP7023371 B2 JP 7023371B2
- Authority
- JP
- Japan
- Prior art keywords
- cholestasis
- agent according
- ceradelpal
- pruritus
- day
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Farming Of Fish And Shellfish (AREA)
- Pyrane Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Ladders (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762563395P | 2017-09-26 | 2017-09-26 | |
| US62/563,395 | 2017-09-26 | ||
| PCT/US2018/052490 WO2019067373A1 (en) | 2017-09-26 | 2018-09-24 | TREATMENT OF CHOLESTATIC PRURIT |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020535225A JP2020535225A (ja) | 2020-12-03 |
| JP2020535225A5 JP2020535225A5 (enExample) | 2021-11-04 |
| JP7023371B2 true JP7023371B2 (ja) | 2022-02-21 |
Family
ID=64564950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020538758A Active JP7023371B2 (ja) | 2017-09-26 | 2018-09-24 | 胆汁うっ滞性そう痒の処置 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US20190105291A1 (enExample) |
| EP (3) | EP3687523B1 (enExample) |
| JP (1) | JP7023371B2 (enExample) |
| KR (1) | KR102376794B1 (enExample) |
| CN (1) | CN111132675B (enExample) |
| AU (2) | AU2018342323B2 (enExample) |
| BR (1) | BR112020005074A2 (enExample) |
| CA (1) | CA3076614C (enExample) |
| CY (1) | CY1124894T1 (enExample) |
| DK (1) | DK3973959T3 (enExample) |
| ES (2) | ES3012120T3 (enExample) |
| FI (1) | FI3973959T3 (enExample) |
| HR (2) | HRP20250022T1 (enExample) |
| HU (2) | HUE070033T2 (enExample) |
| IL (2) | IL273569B (enExample) |
| LT (2) | LT3973959T (enExample) |
| MX (1) | MX392537B (enExample) |
| PL (2) | PL3973959T3 (enExample) |
| PT (2) | PT3687523T (enExample) |
| RS (1) | RS62790B1 (enExample) |
| SG (1) | SG11202002253SA (enExample) |
| SI (2) | SI3687523T1 (enExample) |
| SM (1) | SMT202200171T1 (enExample) |
| UA (1) | UA125600C2 (enExample) |
| WO (1) | WO2019067373A1 (enExample) |
| ZA (1) | ZA202001646B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10272058B2 (en) | 2014-03-20 | 2019-04-30 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| ES2701094T3 (es) | 2014-03-20 | 2019-02-20 | Cymabay Therapeutics Inc | Tratamiento de enfermedades colestáticas intrahepáticas |
| US12053445B2 (en) | 2016-03-31 | 2024-08-06 | Genfit | Methods of treatment of cholestatic diseases |
| US10512622B2 (en) | 2017-07-14 | 2019-12-24 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| KR20210078515A (ko) | 2018-10-18 | 2021-06-28 | 아비어, 인크. | 만성 신장 질환-연관 소양증의 치료 방법 및 장치 |
| KR20220140762A (ko) * | 2020-02-10 | 2022-10-18 | 장피트 | 엘라피브라노에 의한 원발 담즙성 담관염의 치료 |
| CN115884765A (zh) | 2020-08-26 | 2023-03-31 | 基恩菲特公司 | 用于治疗原发性胆汁性胆管炎的组合物和方法 |
| CN116490191A (zh) * | 2020-10-20 | 2023-07-25 | 葛兰素史克知识产权第二有限公司 | 治疗胆汁淤积性瘙痒的方法 |
| RS65546B1 (sr) | 2021-02-01 | 2024-06-28 | Cymabay Therapeutics Inc | Tretman holangiopatija sa seladelparom |
| US20240252499A1 (en) | 2023-01-29 | 2024-08-01 | Cymabay Therapeutics, Inc. | Treatment of uremic pruritus |
| KR20250139304A (ko) * | 2023-01-29 | 2025-09-23 | 사이머베이 쎄라퓨틱스, 인코퍼레이티드 | 만성 소양증 피부병의 치료 |
| WO2025250635A1 (en) * | 2024-05-28 | 2025-12-04 | Avior, Inc. | Use of nalmefene hydrochloride buccal films in treating liver disease associated pruritus |
| WO2026030533A1 (en) | 2024-07-31 | 2026-02-05 | Cymabay Therapeutics, Inc. | Seladelpar for use in treating liver disease |
| US20260207538A1 (en) | 2024-12-20 | 2026-07-23 | Gilead Sciences, Inc. | Combinations for liver disease |
| CN121023009A (zh) * | 2025-10-31 | 2025-11-28 | 浙江大学医学院附属妇产科医院(浙江省妇女医院、浙江省妇女保健院) | 基于唾液样本的妊娠期肝内胆汁淤积症易感基因多重pcr—ngs筛查方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017508817A (ja) | 2014-03-20 | 2017-03-30 | サイマベイ・セラピューティクス・インコーポレイテッドＣｙｍａＢａｙ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 肝内胆汁うっ滞症の治療 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA87467C2 (xx) | 2003-09-19 | 2009-07-27 | Янссен Фармацевтика Н.В | 4-((феноксіалкіл)тіо)феноксіоцтова кислота та її аналоги$4-((феноксиалкил)тио)феноксиуксусная кислота и ее аналоги |
| JO3006B1 (ar) | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| JP2020533339A (ja) * | 2017-09-13 | 2020-11-19 | ノバルティス アーゲー | Ｆｘｒアゴニストを含む組合せ |
-
2018
- 2018-09-24 JP JP2020538758A patent/JP7023371B2/ja active Active
- 2018-09-24 HR HRP20250022TT patent/HRP20250022T1/hr unknown
- 2018-09-24 ES ES21201888T patent/ES3012120T3/es active Active
- 2018-09-24 RS RS20211484A patent/RS62790B1/sr unknown
- 2018-09-24 EP EP18811954.9A patent/EP3687523B1/en active Active
- 2018-09-24 SI SI201830493T patent/SI3687523T1/sl unknown
- 2018-09-24 SI SI201831200T patent/SI3973959T1/sl unknown
- 2018-09-24 KR KR1020207011163A patent/KR102376794B1/ko active Active
- 2018-09-24 CA CA3076614A patent/CA3076614C/en active Active
- 2018-09-24 EP EP21201888.1A patent/EP3973959B8/en active Active
- 2018-09-24 LT LTEP21201888.1T patent/LT3973959T/lt unknown
- 2018-09-24 MX MX2020007273A patent/MX392537B/es unknown
- 2018-09-24 BR BR112020005074-1A patent/BR112020005074A2/pt not_active Application Discontinuation
- 2018-09-24 FI FIEP21201888.1T patent/FI3973959T3/fi active
- 2018-09-24 HU HUE21201888A patent/HUE070033T2/hu unknown
- 2018-09-24 EP EP24215203.1A patent/EP4523744A3/en active Pending
- 2018-09-24 CN CN201880062348.XA patent/CN111132675B/zh active Active
- 2018-09-24 ES ES18811954T patent/ES2902349T3/es active Active
- 2018-09-24 HU HUE18811954A patent/HUE057377T2/hu unknown
- 2018-09-24 PT PT188119549T patent/PT3687523T/pt unknown
- 2018-09-24 DK DK21201888.1T patent/DK3973959T3/da active
- 2018-09-24 HR HRP20212010TT patent/HRP20212010T1/hr unknown
- 2018-09-24 SM SM20220171T patent/SMT202200171T1/it unknown
- 2018-09-24 US US16/140,365 patent/US20190105291A1/en not_active Abandoned
- 2018-09-24 AU AU2018342323A patent/AU2018342323B2/en active Active
- 2018-09-24 PT PT212018881T patent/PT3973959T/pt unknown
- 2018-09-24 LT LTEPPCT/US2018/052490T patent/LT3687523T/lt unknown
- 2018-09-24 PL PL21201888.1T patent/PL3973959T3/pl unknown
- 2018-09-24 WO PCT/US2018/052490 patent/WO2019067373A1/en not_active Ceased
- 2018-09-24 PL PL18811954T patent/PL3687523T3/pl unknown
- 2018-09-24 SG SG11202002253SA patent/SG11202002253SA/en unknown
- 2018-09-24 UA UAA202001861A patent/UA125600C2/uk unknown
-
2020
- 2020-03-16 ZA ZA2020/01646A patent/ZA202001646B/en unknown
- 2020-03-24 IL IL273569A patent/IL273569B/en unknown
- 2020-12-21 US US17/128,195 patent/US20210283078A1/en active Pending
-
2021
- 2021-10-22 AU AU2021254641A patent/AU2021254641B2/en active Active
- 2021-11-23 IL IL288340A patent/IL288340B2/en unknown
-
2022
- 2022-01-07 CY CY20221100017T patent/CY1124894T1/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017508817A (ja) | 2014-03-20 | 2017-03-30 | サイマベイ・セラピューティクス・インコーポレイテッドＣｙｍａＢａｙ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 肝内胆汁うっ滞症の治療 |
Non-Patent Citations (2)
| Title |
|---|
| HEPATOLOGY，2014年，Vol. 60, No. 1，pp.399-407 |
| JONES, D. et al.，LB-9, A phase 2 proof concept study of MBX-8025 in patients with Primary Biliary Cholangitis (PBC) who are inadequate responders to ursodeoxycholic acid (UDCA)，HEPATOLOGY，2016年12月，Vol.64, No.6(Suppl.)，pp.1123A-1124A |
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